DoRiNA 2.0—upgrading the doRiNA database of RNA interactions in post-transcriptional regulation

• Published in: Nucleic acids research Vol. 43; no. D1; pp. D160 - D167
• Main Authors: Blin, Kai, Dieterich, Christoph, Wurmus, Ricardo, Rajewsky, Nikolaus, Landthaler, Markus, Akalin, Altuna
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 28.01.2015
• Subjects: Animals; Argonaute Proteins - metabolism; Database Issue; Databases, Genetic; Exons; HEK293 Cells; Humans; Internet; Mice; MicroRNAs - metabolism; Nuclear Proteins - metabolism; RNA - metabolism; RNA Processing, Post-Transcriptional; RNA-Binding Proteins - metabolism; Serine-Arginine Splicing Factors; Software

The expression of almost all genes in animals is subject to post-transcriptional regulation by RNA binding proteins (RBPs) and microRNAs (miRNAs). The interactions between both RBPs and miRNAs with mRNA can be mapped on a whole-transcriptome level using experimental and computational techniques esta...