Chemical composition, in vitro antibacterial and antioxidant potential of Omani Thyme essential oil along with in silico studies of its major constituent
[Display omitted] •Chemical profiling of Omani Thymus vulgaris species was done by GC-MS analysis.•The GC-MS analysis of thyme essential oil established it to be a carvacrol chemotype.•Thyme essential oil exhibited better antimicrobial spectrum than ampicillin.•Thyme essential oil showed significant...
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Published in | Journal of King Saud University. Science Vol. 32; no. 1; pp. 1021 - 1028 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.01.2020
Elsevier |
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Abstract | [Display omitted]
•Chemical profiling of Omani Thymus vulgaris species was done by GC-MS analysis.•The GC-MS analysis of thyme essential oil established it to be a carvacrol chemotype.•Thyme essential oil exhibited better antimicrobial spectrum than ampicillin.•Thyme essential oil showed significant in vitro free radical scavenging activity in DPPH assay method.•In silico PASS prediction studies revealed carvacrol to possess useful bioactivities including cytotoxicity.
Thyme is an evergreen shrub that has been utilized in traditional medicine and culinary packages for centuries because of its aroma and medicinal properties. The medicinal properties of thyme leaves are attributed to its volatile constituents. The study aimed to identify the volatile constituents in the oil extracted from the Thyme sp grown in Oman and to evaluate its in vitro antibacterial and antioxidant activity. Fresh Thyme leaves were collected from Muscat, Sultanate of Oman in the month of September 2018. Thyme oil was isolated from leaves by hydro-distillation. The volatile chemical constituents present in the thyme oil were analyzed by Gas Chromatograph coupled with Mass Spectrometer. The ability of isolated oil to scavenge free radicals was evaluated by an in vitro DPPH assay method while antimicrobial activity was tested against S. aureus and E. coli bacterial strains by disc diffusion method. The bioactivity of the major constituent of the oil was predicted with the help of PASS and CLC-pred software. Molecular docking studies were performed by docking server. GC–MS analysis of thyme oil revealed the presence of 11 components. Carvacrol and γ-terpinene were identified as the major volatile constituents in thyme oil. Thyme oil inhibited 71.57% of DPPH radicals at 40 µg/mL concentration. Thyme oil displayed the better antimicrobial activity than the standard drug ampicillin against both the bacteria. Antiseptic, antiinfective, reductant and antimutagenic bioactivities of carvacrol as predicted by PASS support the in vitro experimental results. CLC-pred showed carvacrol to be active against Metastatic melanoma, Oligodendroglioma and Non small cell lung cancer cell lines. The antioxidant and antimicrobial activity of Omani thyme oil could be due to its high content of carvacrol. Omani thyme oil seems to be a viable alternative source of natural antimicrobial agent(s) and warrants further studies to ascertain its therapeutic spectrum of biological studies. |
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AbstractList | Thyme is an evergreen shrub that has been utilized in traditional medicine and culinary packages for centuries because of its aroma and medicinal properties. The medicinal properties of thyme leaves are attributed to its volatile constituents. The study aimed to identify the volatile constituents in the oil extracted from the Thyme sp grown in Oman and to evaluate its in vitro antibacterial and antioxidant activity. Fresh Thyme leaves were collected from Muscat, Sultanate of Oman in the month of September 2018. Thyme oil was isolated from leaves by hydro-distillation. The volatile chemical constituents present in the thyme oil were analyzed by Gas Chromatograph coupled with Mass Spectrometer. The ability of isolated oil to scavenge free radicals was evaluated by an in vitro DPPH assay method while antimicrobial activity was tested against S. aureus and E. coli bacterial strains by disc diffusion method. The bioactivity of the major constituent of the oil was predicted with the help of PASS and CLC-pred software. Molecular docking studies were performed by docking server. GC–MS analysis of thyme oil revealed the presence of 11 components. Carvacrol and γ-terpinene were identified as the major volatile constituents in thyme oil. Thyme oil inhibited 71.57% of DPPH radicals at 40 µg/mL concentration. Thyme oil displayed the better antimicrobial activity than the standard drug ampicillin against both the bacteria. Antiseptic, antiinfective, reductant and antimutagenic bioactivities of carvacrol as predicted by PASS support the in vitro experimental results. CLC-pred showed carvacrol to be active against Metastatic melanoma, Oligodendroglioma and Non small cell lung cancer cell lines. The antioxidant and antimicrobial activity of Omani thyme oil could be due to its high content of carvacrol. Omani thyme oil seems to be a viable alternative source of natural antimicrobial agent(s) and warrants further studies to ascertain its therapeutic spectrum of biological studies. Keywords: Antimicrobial, Antioxidant, DPPH, Essential oil, Hydro-distillation, Thyme [Display omitted] •Chemical profiling of Omani Thymus vulgaris species was done by GC-MS analysis.•The GC-MS analysis of thyme essential oil established it to be a carvacrol chemotype.•Thyme essential oil exhibited better antimicrobial spectrum than ampicillin.•Thyme essential oil showed significant in vitro free radical scavenging activity in DPPH assay method.•In silico PASS prediction studies revealed carvacrol to possess useful bioactivities including cytotoxicity. Thyme is an evergreen shrub that has been utilized in traditional medicine and culinary packages for centuries because of its aroma and medicinal properties. The medicinal properties of thyme leaves are attributed to its volatile constituents. The study aimed to identify the volatile constituents in the oil extracted from the Thyme sp grown in Oman and to evaluate its in vitro antibacterial and antioxidant activity. Fresh Thyme leaves were collected from Muscat, Sultanate of Oman in the month of September 2018. Thyme oil was isolated from leaves by hydro-distillation. The volatile chemical constituents present in the thyme oil were analyzed by Gas Chromatograph coupled with Mass Spectrometer. The ability of isolated oil to scavenge free radicals was evaluated by an in vitro DPPH assay method while antimicrobial activity was tested against S. aureus and E. coli bacterial strains by disc diffusion method. The bioactivity of the major constituent of the oil was predicted with the help of PASS and CLC-pred software. Molecular docking studies were performed by docking server. GC–MS analysis of thyme oil revealed the presence of 11 components. Carvacrol and γ-terpinene were identified as the major volatile constituents in thyme oil. Thyme oil inhibited 71.57% of DPPH radicals at 40 µg/mL concentration. Thyme oil displayed the better antimicrobial activity than the standard drug ampicillin against both the bacteria. Antiseptic, antiinfective, reductant and antimutagenic bioactivities of carvacrol as predicted by PASS support the in vitro experimental results. CLC-pred showed carvacrol to be active against Metastatic melanoma, Oligodendroglioma and Non small cell lung cancer cell lines. The antioxidant and antimicrobial activity of Omani thyme oil could be due to its high content of carvacrol. Omani thyme oil seems to be a viable alternative source of natural antimicrobial agent(s) and warrants further studies to ascertain its therapeutic spectrum of biological studies. |
Author | Hadi, Zainab Al-Lawati, Wafa Mustafa Al Lawati, Amal Abdullah Alsaraf, Shahad Khan, Shah Alam |
Author_xml | – sequence: 1 givenname: Shahad surname: Alsaraf fullname: Alsaraf, Shahad organization: College of Pharmacy, National University of Science and Technology, Muscat, Oman – sequence: 2 givenname: Zainab surname: Hadi fullname: Hadi, Zainab organization: College of Pharmacy, National University of Science and Technology, Muscat, Oman – sequence: 3 givenname: Wafa Mustafa surname: Al-Lawati fullname: Al-Lawati, Wafa Mustafa organization: Department of Applied Sciences, Higher College of Technology, Alkhuwair, Muscat, Oman – sequence: 4 givenname: Amal Abdullah surname: Al Lawati fullname: Al Lawati, Amal Abdullah organization: College of Pharmacy, National University of Science and Technology, Muscat, Oman – sequence: 5 givenname: Shah Alam surname: Khan fullname: Khan, Shah Alam email: shahalam@nu.edu.om, sakhan@omc.edu.om organization: College of Pharmacy, National University of Science and Technology, Muscat, Oman |
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Cites_doi | 10.1016/j.indcrop.2013.04.004 10.1111/j.1472-765X.2008.02407.x 10.1016/j.apjtb.2015.05.007 10.1016/S0022-2860(03)00517-9 10.1080/J157v04n01_07 10.1046/j.1472-765X.1999.00605.x 10.1016/j.fitote.2006.03.013 10.1080/07352681003617483 10.1016/j.fm.2003.08.009 10.1002/ptr.1796 10.1002/ffj.1800 10.1016/S0308-8146(98)00013-2 10.1016/j.foodcont.2007.07.007 10.1016/j.indcrop.2013.07.052 10.1016/j.foodchem.2010.10.011 |
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References | Grigore, Paraschiv, Colceru-Mihul, Bubueanu, Draghici, Ichim (b0050) 2010; 15 Al-Breiki, Al-Brashdi, Al-Sabahi, Khan (b0010) 2018; 45 Yamazaki, Yamamoto, Kawai, Inoue (b0115) 2004; 21 Shrivastava, Roger, Wszelaki, Panthee, Chen (b0105) 2010; 29 De Lisi, Tedone, Montesano, Sarli, Negro (b0045) 2011; 125 Dashti, Mirlohi, Dashti, Maryam, Esfahani (b0040) 2015; 1 Basch, Ulbricht, Hammerness, Blevins, Sollars (b0025) 2004; 4 Al-Aamri, Al-Abousi, Al-Jabri, Alam, Khan (b0005) 2018; 13 Ballester-Costa, Sendra, Fernández-López, Pérez-Álvarez, Viuda-Martos (b0020) 2013; 50 Boskabady, Aslani, Kiani (b0030) 2006; 20 Schelz, Molnar, Hohmann (b0095) 2008; 77 Ali, Al-Wabel, Shams, Ahmad, Khan, Anwar (b0015) 2015; 5 Imelouane, Amhamdi, Wathelet, Ankit, Khedid, El Bachiri (b0065) 2009; 11 Nath, Khan, Ahmad (b0080) 2014; 3 Pirbalouti, Hashemi, Ghahfarokhi (b0085) 2013; 48 Xu, Zhou, Ji, Pei, Xu (b0110) 2008; 47 Khan, Inyatullah, Shafee, Shafiq (b0070) 2017; 10 Rota, Herrera, Martínez, Sotomayor, Jordán (b0090) 2008; 19 Hudaib, Aburjai (b0060) 2007; 22 Mohammed, Akhtar, Said, Weli, Al-Sabahi, Al-Riyami, Al-Abri (b0075) 2016; 19 Cosentino, Tuberoso, Pisano, Satta, Mascia, Arzedi, Palmas (b0035) 1999; 29 Guillen, Manzanos (b0055) 1998; 63 Schulz, Quilitzsch, Kruger (b0100) 2003; 661–662 Hudaib (10.1016/j.jksus.2019.09.006_b0060) 2007; 22 Al-Breiki (10.1016/j.jksus.2019.09.006_b0010) 2018; 45 Nath (10.1016/j.jksus.2019.09.006_b0080) 2014; 3 Al-Aamri (10.1016/j.jksus.2019.09.006_b0005) 2018; 13 Ali (10.1016/j.jksus.2019.09.006_b0015) 2015; 5 Xu (10.1016/j.jksus.2019.09.006_b0110) 2008; 47 Cosentino (10.1016/j.jksus.2019.09.006_b0035) 1999; 29 Guillen (10.1016/j.jksus.2019.09.006_b0055) 1998; 63 Basch (10.1016/j.jksus.2019.09.006_b0025) 2004; 4 Khan (10.1016/j.jksus.2019.09.006_b0070) 2017; 10 Mohammed (10.1016/j.jksus.2019.09.006_b0075) 2016; 19 Boskabady (10.1016/j.jksus.2019.09.006_b0030) 2006; 20 Ballester-Costa (10.1016/j.jksus.2019.09.006_b0020) 2013; 50 Yamazaki (10.1016/j.jksus.2019.09.006_b0115) 2004; 21 Grigore (10.1016/j.jksus.2019.09.006_b0050) 2010; 15 Pirbalouti (10.1016/j.jksus.2019.09.006_b0085) 2013; 48 Schelz (10.1016/j.jksus.2019.09.006_b0095) 2008; 77 Schulz (10.1016/j.jksus.2019.09.006_b0100) 2003; 661–662 Rota (10.1016/j.jksus.2019.09.006_b0090) 2008; 19 Dashti (10.1016/j.jksus.2019.09.006_b0040) 2015; 1 Shrivastava (10.1016/j.jksus.2019.09.006_b0105) 2010; 29 De Lisi (10.1016/j.jksus.2019.09.006_b0045) 2011; 125 Imelouane (10.1016/j.jksus.2019.09.006_b0065) 2009; 11 |
References_xml | – volume: 77 start-page: 279 year: 2008 end-page: 285 ident: b0095 article-title: Antimicrobial and antiplasmid activities of essential oils publication-title: Fitoterapia contributor: fullname: Hohmann – volume: 13 start-page: 108 year: 2018 end-page: 112 ident: b0005 article-title: Chemical composition and publication-title: J. Taibah Univ. Med. Sci. contributor: fullname: Khan – volume: 45 start-page: 1782 year: 2018 end-page: 1795 ident: b0010 article-title: Comparative GC-MS analysis, in-vitro antioxidant and antimicrobial activities of the essential oils isolated from the peel of Omani lime publication-title: Chiang Mai J. Sci. contributor: fullname: Khan – volume: 19 start-page: 475 year: 2016 end-page: 478 ident: b0075 article-title: Composition of essential oil of publication-title: JEOP contributor: fullname: Al-Abri – volume: 11 start-page: 205 year: 2009 end-page: 208 ident: b0065 article-title: Chemical composition and antimicrobial activity of essential oil of Thyme ( publication-title: Int. J. Agric. Biol. contributor: fullname: El Bachiri – volume: 22 start-page: 322 year: 2007 end-page: 327 ident: b0060 article-title: Volatile components of publication-title: Flavour Fragr. J. contributor: fullname: Aburjai – volume: 29 start-page: 123 year: 2010 end-page: 133 ident: b0105 article-title: Plant volatiles-based insect pest management in organic farming publication-title: Crit. Rev. Plant Sci. contributor: fullname: Chen – volume: 10 start-page: 105 year: 2017 end-page: 110 ident: b0070 article-title: Antimicrobial activities of thyme essential oil cultivated in Quetta, Balochistan publication-title: Pakistan Int. J. Biosci. contributor: fullname: Shafiq – volume: 19 start-page: 681 year: 2008 end-page: 687 ident: b0090 article-title: Antimicrobial activity and chemical composition of publication-title: Food Control. contributor: fullname: Jordán – volume: 63 start-page: 373 year: 1998 end-page: 383 ident: b0055 article-title: Study of the composition of the different parts of a Spanish publication-title: Food Chem. contributor: fullname: Manzanos – volume: 47 start-page: 174 year: 2008 end-page: 179 ident: b0110 article-title: The antibacterial mechanism of carvacrol and thymol against publication-title: Lett. App. Microbiol. contributor: fullname: Xu – volume: 50 start-page: 304 year: 2013 end-page: 311 ident: b0020 article-title: Chemical composition and publication-title: Ind. Crop. Prod. contributor: fullname: Viuda-Martos – volume: 15 start-page: 5436 year: 2010 end-page: 5443 ident: b0050 article-title: Chemical composition and antioxidant activity of publication-title: Rom. Biotech. Lett. contributor: fullname: Ichim – volume: 48 start-page: 43 year: 2013 end-page: 48 ident: b0085 article-title: Essential oil and chemical compositions of wild and cultivated publication-title: Ind. Crop. Prod. contributor: fullname: Ghahfarokhi – volume: 661–662 start-page: 299 year: 2003 end-page: 306 ident: b0100 article-title: Rapid evaluation and quantitative analysis of thyme, origano and chamomile essential oils by ATR-IR and NIR spectroscopy publication-title: J. Mol. Struct. contributor: fullname: Kruger – volume: 29 start-page: 130 year: 1999 end-page: 135 ident: b0035 article-title: In vitro antimicrobial activity and chemical composition of Sardinian Thymus essential oils publication-title: Lett. Appl. Microbiol. contributor: fullname: Palmas – volume: 5 start-page: 601 year: 2015 end-page: 611 ident: b0015 article-title: Essential oils used in aromatherapy: a systemic review publication-title: Asian Pac. J. Trop. Biomed. contributor: fullname: Anwar – volume: 20 start-page: 28 year: 2006 end-page: 33 ident: b0030 article-title: Relaxant effect of publication-title: Phytother. Res. contributor: fullname: Kiani – volume: 21 start-page: 283 year: 2004 end-page: 289 ident: b0115 article-title: Enhancement of antilisterial activity of essential oil constituents by nisin and diglycerol fatty acid ester publication-title: Food Microbiol. contributor: fullname: Inoue – volume: 4 start-page: 49 year: 2004 end-page: 67 ident: b0025 article-title: Thyme ( publication-title: J. Herb. Pharmacother. contributor: fullname: Sollars – volume: 125 start-page: 1284 year: 2011 end-page: 1286 ident: b0045 article-title: Chemical characterization of Thymus populations belonging from Southern Italy publication-title: Food Chem. contributor: fullname: Negro – volume: 3 start-page: 496 year: 2014 end-page: 503 ident: b0080 article-title: Computer aided screening of natural products in search of lead molecules for design and development of potent anti-inflammatory agents publication-title: Sch. Acad. J. Pharm. contributor: fullname: Ahmad – volume: 1 start-page: 115 year: 2015 end-page: 120 ident: b0040 article-title: Antioxidant effect of thyme essential oil on oxidative stability of chicken nuggets publication-title: Int. J. Food Eng. contributor: fullname: Esfahani – volume: 11 start-page: 205 year: 2009 ident: 10.1016/j.jksus.2019.09.006_b0065 article-title: Chemical composition and antimicrobial activity of essential oil of Thyme (Thymus vulgaris) from Eastern Morocco publication-title: Int. J. Agric. Biol. contributor: fullname: Imelouane – volume: 48 start-page: 43 year: 2013 ident: 10.1016/j.jksus.2019.09.006_b0085 article-title: Essential oil and chemical compositions of wild and cultivated Thymus daenensis Celak and Thymus vulgaris L publication-title: Ind. Crop. Prod. doi: 10.1016/j.indcrop.2013.04.004 contributor: fullname: Pirbalouti – volume: 47 start-page: 174 year: 2008 ident: 10.1016/j.jksus.2019.09.006_b0110 article-title: The antibacterial mechanism of carvacrol and thymol against Escherichia coli publication-title: Lett. App. Microbiol. doi: 10.1111/j.1472-765X.2008.02407.x contributor: fullname: Xu – volume: 10 start-page: 105 year: 2017 ident: 10.1016/j.jksus.2019.09.006_b0070 article-title: Antimicrobial activities of thyme essential oil cultivated in Quetta, Balochistan publication-title: Pakistan Int. J. Biosci. contributor: fullname: Khan – volume: 5 start-page: 601 year: 2015 ident: 10.1016/j.jksus.2019.09.006_b0015 article-title: Essential oils used in aromatherapy: a systemic review publication-title: Asian Pac. J. Trop. Biomed. doi: 10.1016/j.apjtb.2015.05.007 contributor: fullname: Ali – volume: 1 start-page: 115 year: 2015 ident: 10.1016/j.jksus.2019.09.006_b0040 article-title: Antioxidant effect of thyme essential oil on oxidative stability of chicken nuggets publication-title: Int. J. Food Eng. contributor: fullname: Dashti – volume: 661–662 start-page: 299 year: 2003 ident: 10.1016/j.jksus.2019.09.006_b0100 article-title: Rapid evaluation and quantitative analysis of thyme, origano and chamomile essential oils by ATR-IR and NIR spectroscopy publication-title: J. Mol. Struct. doi: 10.1016/S0022-2860(03)00517-9 contributor: fullname: Schulz – volume: 3 start-page: 496 issue: 6 year: 2014 ident: 10.1016/j.jksus.2019.09.006_b0080 article-title: Computer aided screening of natural products in search of lead molecules for design and development of potent anti-inflammatory agents publication-title: Sch. Acad. J. Pharm. contributor: fullname: Nath – volume: 19 start-page: 475 year: 2016 ident: 10.1016/j.jksus.2019.09.006_b0075 article-title: Composition of essential oil of Thymus vulgaris grown in Oman publication-title: JEOP contributor: fullname: Mohammed – volume: 13 start-page: 108 year: 2018 ident: 10.1016/j.jksus.2019.09.006_b0005 article-title: Chemical composition and in-vitro antioxidant and antimicrobial activity of the essential oil of Citrus aurantifolia L. leaves grown in Eastern Oman publication-title: J. Taibah Univ. Med. Sci. contributor: fullname: Al-Aamri – volume: 4 start-page: 49 year: 2004 ident: 10.1016/j.jksus.2019.09.006_b0025 article-title: Thyme (Thymus vulgaris L.), thymol publication-title: J. Herb. Pharmacother. doi: 10.1080/J157v04n01_07 contributor: fullname: Basch – volume: 29 start-page: 130 year: 1999 ident: 10.1016/j.jksus.2019.09.006_b0035 article-title: In vitro antimicrobial activity and chemical composition of Sardinian Thymus essential oils publication-title: Lett. Appl. Microbiol. doi: 10.1046/j.1472-765X.1999.00605.x contributor: fullname: Cosentino – volume: 77 start-page: 279 year: 2008 ident: 10.1016/j.jksus.2019.09.006_b0095 article-title: Antimicrobial and antiplasmid activities of essential oils publication-title: Fitoterapia doi: 10.1016/j.fitote.2006.03.013 contributor: fullname: Schelz – volume: 29 start-page: 123 year: 2010 ident: 10.1016/j.jksus.2019.09.006_b0105 article-title: Plant volatiles-based insect pest management in organic farming publication-title: Crit. Rev. Plant Sci. doi: 10.1080/07352681003617483 contributor: fullname: Shrivastava – volume: 21 start-page: 283 year: 2004 ident: 10.1016/j.jksus.2019.09.006_b0115 article-title: Enhancement of antilisterial activity of essential oil constituents by nisin and diglycerol fatty acid ester publication-title: Food Microbiol. doi: 10.1016/j.fm.2003.08.009 contributor: fullname: Yamazaki – volume: 20 start-page: 28 year: 2006 ident: 10.1016/j.jksus.2019.09.006_b0030 article-title: Relaxant effect of Thymus vulgaris on guinea-pig tracheal chains and its possible mechanism(s) publication-title: Phytother. Res. doi: 10.1002/ptr.1796 contributor: fullname: Boskabady – volume: 22 start-page: 322 year: 2007 ident: 10.1016/j.jksus.2019.09.006_b0060 article-title: Volatile components of Thymus vulgaris L. from wild-growing and cultivated plants in Jordan publication-title: Flavour Fragr. J. doi: 10.1002/ffj.1800 contributor: fullname: Hudaib – volume: 63 start-page: 373 year: 1998 ident: 10.1016/j.jksus.2019.09.006_b0055 article-title: Study of the composition of the different parts of a Spanish Thymus vulgaris L. plant publication-title: Food Chem. doi: 10.1016/S0308-8146(98)00013-2 contributor: fullname: Guillen – volume: 19 start-page: 681 year: 2008 ident: 10.1016/j.jksus.2019.09.006_b0090 article-title: Antimicrobial activity and chemical composition of Thymus vulgaris, Thymus zygis and Thymus hyemalis essential oils publication-title: Food Control. doi: 10.1016/j.foodcont.2007.07.007 contributor: fullname: Rota – volume: 50 start-page: 304 year: 2013 ident: 10.1016/j.jksus.2019.09.006_b0020 article-title: Chemical composition and in vitro antibacterial properties of essential oils of four Thymus species from organic growth publication-title: Ind. Crop. Prod. doi: 10.1016/j.indcrop.2013.07.052 contributor: fullname: Ballester-Costa – volume: 45 start-page: 1782 year: 2018 ident: 10.1016/j.jksus.2019.09.006_b0010 article-title: Comparative GC-MS analysis, in-vitro antioxidant and antimicrobial activities of the essential oils isolated from the peel of Omani lime publication-title: Chiang Mai J. Sci. contributor: fullname: Al-Breiki – volume: 125 start-page: 1284 year: 2011 ident: 10.1016/j.jksus.2019.09.006_b0045 article-title: Chemical characterization of Thymus populations belonging from Southern Italy publication-title: Food Chem. doi: 10.1016/j.foodchem.2010.10.011 contributor: fullname: De Lisi – volume: 15 start-page: 5436 year: 2010 ident: 10.1016/j.jksus.2019.09.006_b0050 article-title: Chemical composition and antioxidant activity of Thymus vulgaris L. volatile oil obtained by two different methods publication-title: Rom. Biotech. Lett. contributor: fullname: Grigore |
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•Chemical profiling of Omani Thymus vulgaris species was done by GC-MS analysis.•The GC-MS analysis of thyme essential oil established it to... Thyme is an evergreen shrub that has been utilized in traditional medicine and culinary packages for centuries because of its aroma and medicinal properties.... |
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SubjectTerms | Antimicrobial Antioxidant DPPH Essential oil Hydro-distillation Thyme |
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Title | Chemical composition, in vitro antibacterial and antioxidant potential of Omani Thyme essential oil along with in silico studies of its major constituent |
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