Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization

• Published in: Diabetes (New York, N.Y.) Vol. 71; no. 5; pp. 1099 - 1114
• Main Authors: Zhao, Lei, Zhang, Cheng-Lin, He, Lei, Chen, Qinghua, Liu, Limei, Kang, Lijing, Liu, Jian, Luo, Jiang-Yun, Gou, Lingshan, Qu, Dan, Song, Wencong, Lau, Chi Wai, Ko, Ho, Mok, Vincent C.T., Tian, Xiao Yu, Wang, Li, Huang, Yu
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.05.2022
• Subjects: Advanced glycosylation end products; Animals; Autophagy; Bioavailability; Chloroquine; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - metabolism; Dimerization; Endothelial cells; Endothelial Cells - metabolism; Endothelium; Endothelium, Vascular - metabolism; Glycosylation; Localization; Mammals - metabolism; Mice; Mice, Inbred C57BL; Mitochondria; Nitric oxide; Nitric Oxide Synthase Type III - genetics; Nitric Oxide Synthase Type III - metabolism; Nitric-oxide synthase; Nutrient deficiency; Oxidative stress; Rapamycin; Reactive oxygen species; Reactive Oxygen Species - metabolism; TOR protein

Endothelial nitric oxide synthase (eNOS) monomerization and uncoupling play crucial roles in mediating vascular dysfunction in diabetes, although the underlying mechanisms are still incompletely understood. Increasing evidence indicates that autophagic dysregulation is involved in the pathogenesis o...