Arsenite Exposure Displaces Zinc from ZRANB2 Leading to Altered Splicing

• Published in: Chemical research in toxicology Vol. 33; no. 6; pp. 1403 - 1417
• Main Authors: Banerjee, Mayukh, Ferragut Cardoso, Ana P, Lykoudi, Angeliki, Wilkey, Daniel W, Pan, Jianmin, Watson, Walter H, Garbett, Nichola C, Rai, Shesh N, Merchant, Michael L, States, J Christopher
• Format: Journal Article
• Language: English
• Published: United States 15.06.2020

Exposure to arsenic, a class I carcinogen, affects 200 million people globally. Skin is the major target organ, but the molecular etiology of arsenic-induced skin carcinogenesis remains unclear. Arsenite (As )-induced disruption of alternative splicing could be involved, but the mechanism is unknown...