A dual-modality immunosensor for simple and reliable detection of nitrated alpha-synuclein in serum based on silver-coated MOF

• Published in: Mikrochimica acta (1966) Vol. 190; no. 5; p. 196
• Main Authors: Xu, Xiaohui, Chen, Jie, Hu, Ruhui, Zhang, Yajing, Chen, Hongxia, Hu, Xiaojun, Zhang, Zhaohuan
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.05.2023; Springer; Springer Nature B.V
• Subjects: alpha-Synuclein; Analysis; Analytical Chemistry; Antibodies; Biomarkers; Biosensing Techniques; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Colorimetry; Copper; Diagnosis; Electric properties; Electrochemical analysis; Humans; Immunoassay; Immunosensors; Magnetic separation; Metal Nanoparticles - chemistry; Metal-Organic Frameworks - chemistry; Microengineering; Nanochemistry; Nanoparticles; Nanotechnology; Nitrates; Original Paper; Oxidase; Oxidases; Oxidizing agents; Oxidoreductases; Sensors; Signal analysis; Silver; Silver - chemistry; Stability; Substrates; Electrochemistry; Metal–organic framework; Oxidase activity; Colorimetry; Nitrated α-syn; Differential pulse voltammetry

Nitrated α-syn (nitro-α-syn) is a biomarker for Parkinson's desease (PD), and its sensitive detection in serum is of great importance for early PD diagnosis. Silver-coated copper MOF (Cu-MOF@Ag) with outstanding oxidase activity and electrochemical response property was designed and synthesized...