Secretory Pathway Quality Control Operating in Golgi, Plasmalemmal, and Endosomal Systems

• Published in: Traffic (Copenhagen, Denmark) Vol. 3; no. 11; pp. 771 - 780
• Main Authors: Arvan, Peter, Zhao, Xiang, Ramos‐Castaneda, Jose, Chang, Amy
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2002
• Subjects: Animals; Biological Transport; Carrier Proteins - metabolism; Cell Membrane - metabolism; degradation; Endoplasmic Reticulum - metabolism; Endosomes - metabolism; Golgi Apparatus - metabolism; Humans; Membrane Proteins - metabolism; Models, Biological; multivesicular endosome; proteasome; Protein Transport; ubiquitylation; vps genes

Exportable proteins that have significant defects in nascent polypeptide folding or subunit assembly are frequently retained in the endoplasmic reticulum and subject to endoplasmic reticulum‐associated degradation by the ubiquitin‐proteasome system. In addition to this, however, there is growing evi...