Bone Age Advancement in Prepubertal Children With Obesity and Premature Adrenarche: Possible Potentiating Factors
Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a sp...
Saved in:
| Published in | Obesity (Silver Spring, Md.) Vol. 19; no. 6; pp. 1259 - 1264 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.06.2011
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1930-7381 1930-739X 1930-739X |
| DOI | 10.1038/oby.2010.305 |
Cover
| Abstract | Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a spectrum of prepubertal children with and without obesity and PA. In this cross‐sectional study of 66 prepubertal children (35 PA, 31 control, 5–9 years), BMI z‐score, hormonal values and response to an oral glucose tolerance test were the main outcome measures. Subjects were divided into tertiles by BA divided by chronological age (BA/CA), an index of BA advancement. Subjects in the top tertile for BA/CA had the highest dehydroepiandrosterone sulfate (DHEAS), free testosterone (%), hemoglobin A1C, BMI z‐score, and weight (P < 0.05). BMI z‐score (r = 0.47), weight (r = 0.40), free testosterone (%) (r = 0.34), and DHEAS (r = 0.30) correlated with BA/CA (P < 0.02). Regression analysis showed greater BA/CA in PA compared to controls after controlling for weight (0.21 ± 0.56, P < 0.004). An exploratory stepwise regression model showed that weight, estradiol, and DHEAS were the strongest predictors of BA/CA accounting for 24% of its variance. Obesity was highly associated with BA advancement in this study of prepubertal children. In addition, children with PA had greater BA/CA at any given weight when compared to controls. These findings suggest a possible hormonal factor, which potentiates the effect of obesity on BA advancement in children with obesity and/or PA. |
|---|---|
| AbstractList | Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a spectrum of prepubertal children with and without obesity and PA. In this cross-sectional study of 66 prepubertal children (35 PA, 31 control, 5-9 years), BMI z-score, hormonal values and response to an oral glucose tolerance test were the main outcome measures. Subjects were divided into tertiles by BA divided by chronological age (BA/CA), an index of BA advancement. Subjects in the top tertile for BA/CA had the highest dehydroepiandrosterone sulfate (DHEAS), free testosterone (%), hemoglobin A(1C), BMI z-score, and weight (P < 0.05). BMI z-score (r = 0.47), weight (r = 0.40), free testosterone (%) (r = 0.34), and DHEAS (r = 0.30) correlated with BA/CA (P < 0.02). Regression analysis showed greater BA/CA in PA compared to controls after controlling for weight (0.21 ± 0.56, P < 0.004). An exploratory stepwise regression model showed that weight, estradiol, and DHEAS were the strongest predictors of BA/CA accounting for 24% of its variance. Obesity was highly associated with BA advancement in this study of prepubertal children. In addition, children with PA had greater BA/CA at any given weight when compared to controls. These findings suggest a possible hormonal factor, which potentiates the effect of obesity on BA advancement in children with obesity and/or PA. Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a spectrum of prepubertal children with and without obesity and PA. In this cross‐sectional study of 66 prepubertal children (35 PA, 31 control, 5–9 years), BMI z ‐score, hormonal values and response to an oral glucose tolerance test were the main outcome measures. Subjects were divided into tertiles by BA divided by chronological age (BA/CA), an index of BA advancement. Subjects in the top tertile for BA/CA had the highest dehydroepiandrosterone sulfate (DHEAS), free testosterone (%), hemoglobin A 1C , BMI z ‐score, and weight ( P < 0.05). BMI z ‐score ( r = 0.47), weight ( r = 0.40), free testosterone (%) ( r = 0.34), and DHEAS ( r = 0.30) correlated with BA/CA ( P < 0.02). Regression analysis showed greater BA/CA in PA compared to controls after controlling for weight (0.21 ± 0.56, P < 0.004). An exploratory stepwise regression model showed that weight, estradiol, and DHEAS were the strongest predictors of BA/CA accounting for 24% of its variance. Obesity was highly associated with BA advancement in this study of prepubertal children. In addition, children with PA had greater BA/CA at any given weight when compared to controls. These findings suggest a possible hormonal factor, which potentiates the effect of obesity on BA advancement in children with obesity and/or PA. Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a spectrum of prepubertal children with and without obesity and PA. In this cross-sectional study of 66 prepubertal children (35 PA, 31 control, 5-9 years), BMI z-score, hormonal values and response to an oral glucose tolerance test were the main outcome measures. Subjects were divided into tertiles by BA divided by chronological age (BA/CA), an index of BA advancement. Subjects in the top tertile for BA/CA had the highest dehydroepiandrosterone sulfate (DHEAS), free testosterone (%), hemoglobin A(1C), BMI z-score, and weight (P < 0.05). BMI z-score (r = 0.47), weight (r = 0.40), free testosterone (%) (r = 0.34), and DHEAS (r = 0.30) correlated with BA/CA (P < 0.02). Regression analysis showed greater BA/CA in PA compared to controls after controlling for weight (0.21 ± 0.56, P < 0.004). An exploratory stepwise regression model showed that weight, estradiol, and DHEAS were the strongest predictors of BA/CA accounting for 24% of its variance. Obesity was highly associated with BA advancement in this study of prepubertal children. In addition, children with PA had greater BA/CA at any given weight when compared to controls. These findings suggest a possible hormonal factor, which potentiates the effect of obesity on BA advancement in children with obesity and/or PA.Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a spectrum of prepubertal children with and without obesity and PA. In this cross-sectional study of 66 prepubertal children (35 PA, 31 control, 5-9 years), BMI z-score, hormonal values and response to an oral glucose tolerance test were the main outcome measures. Subjects were divided into tertiles by BA divided by chronological age (BA/CA), an index of BA advancement. Subjects in the top tertile for BA/CA had the highest dehydroepiandrosterone sulfate (DHEAS), free testosterone (%), hemoglobin A(1C), BMI z-score, and weight (P < 0.05). BMI z-score (r = 0.47), weight (r = 0.40), free testosterone (%) (r = 0.34), and DHEAS (r = 0.30) correlated with BA/CA (P < 0.02). Regression analysis showed greater BA/CA in PA compared to controls after controlling for weight (0.21 ± 0.56, P < 0.004). An exploratory stepwise regression model showed that weight, estradiol, and DHEAS were the strongest predictors of BA/CA accounting for 24% of its variance. Obesity was highly associated with BA advancement in this study of prepubertal children. In addition, children with PA had greater BA/CA at any given weight when compared to controls. These findings suggest a possible hormonal factor, which potentiates the effect of obesity on BA advancement in children with obesity and/or PA. Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a spectrum of prepubertal children with and without obesity and PA. In this cross-sectional study of 66 prepubertal children (35 PA, 31 control, 59 years), BMI z-score, hormonal values and response to an oral glucose tolerance test were the main outcome measures. Subjects were divided into tertiles by BA divided by chronological age (BA/CA), an index of BA advancement. Subjects in the top tertile for BA/CA had the highest dehydroepiandrosterone sulfate (DHEAS), free testosterone (%), hemoglobin A1C, BMI z-score, and weight (P < 0.05). BMI z-score (r = 0.47), weight (r = 0.40), free testosterone (%) (r = 0.34), and DHEAS (r = 0.30) correlated with BA/CA (P < 0.02). Regression analysis showed greater BA/CA in PA compared to controls after controlling for weight (0.21 0.56, P < 0.004). An exploratory stepwise regression model showed that weight, estradiol, and DHEAS were the strongest predictors of BA/CA accounting for 24% of its variance. Obesity was highly associated with BA advancement in this study of prepubertal children. In addition, children with PA had greater BA/CA at any given weight when compared to controls. These findings suggest a possible hormonal factor, which potentiates the effect of obesity on BA advancement in children with obesity and/or PA. Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a spectrum of prepubertal children with and without obesity and PA. In this cross-sectional study of 66 prepubertal children (35 PA, 31 control, 5–9 years), body mass index (BMI) z-score, hormonal values and response to an oral glucose tolerance test were the main outcome measures. Subjects were divided into tertiles by BA divided by chronological age (BA/CA), an index of BA advancement. Subjects in the top tertile for BA/CA had the highest dehydroepiandrosterone sulfate (DHEAS), free testosterone (%), hemoglobin A 1 C, BMI z-score and weight ( P < 0.05). BMI z-score (r = 0.47), weight (r = 0.40), free testosterone (%) (r = 0.34) and DHEAS (r = 0.30) correlated with BA/CA (P<0.02). Regression analysis showed greater BA/CA in PA compared to controls after controlling for weight (0.21 ± 0.56, p<0.004). An exploratory stepwise regression model showed that weight, estradiol and DHEAS were the strongest predictors of BA/CA accounting for 24% of its variance. Obesity was highly associated with BA advancement in this study of prepubertal children. In addition, children with PA had greater BA/CA at any given weight when compared to controls. These findings suggest a possible hormonal factor, which potentiates the effect of obesity on BA advancement in children with obesity and/or PA. Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a spectrum of prepubertal children with and without obesity and PA. In this cross‐sectional study of 66 prepubertal children (35 PA, 31 control, 5–9 years), BMI z‐score, hormonal values and response to an oral glucose tolerance test were the main outcome measures. Subjects were divided into tertiles by BA divided by chronological age (BA/CA), an index of BA advancement. Subjects in the top tertile for BA/CA had the highest dehydroepiandrosterone sulfate (DHEAS), free testosterone (%), hemoglobin A1C, BMI z‐score, and weight (P < 0.05). BMI z‐score (r = 0.47), weight (r = 0.40), free testosterone (%) (r = 0.34), and DHEAS (r = 0.30) correlated with BA/CA (P < 0.02). Regression analysis showed greater BA/CA in PA compared to controls after controlling for weight (0.21 ± 0.56, P < 0.004). An exploratory stepwise regression model showed that weight, estradiol, and DHEAS were the strongest predictors of BA/CA accounting for 24% of its variance. Obesity was highly associated with BA advancement in this study of prepubertal children. In addition, children with PA had greater BA/CA at any given weight when compared to controls. These findings suggest a possible hormonal factor, which potentiates the effect of obesity on BA advancement in children with obesity and/or PA. |
| Author | Fennoy, Ilene Hassoun, Abeer Sopher, Aviva B. Zwany, Sarah K. Oberfield, Sharon E. Bell, Jennifer J. Winston, Diana M. Jean, Amy M. Pomeranz, Christy B. McMahon, Donald J. |
| AuthorAffiliation | 2 Department of Medicine, Columbia University Medical Center, New York, NY 10032 1 Department of Pediatrics, Columbia University Medical Center, New York, NY 10032 |
| AuthorAffiliation_xml | – name: 1 Department of Pediatrics, Columbia University Medical Center, New York, NY 10032 – name: 2 Department of Medicine, Columbia University Medical Center, New York, NY 10032 |
| Author_xml | – sequence: 1 givenname: Aviva B. surname: Sopher fullname: Sopher, Aviva B. – sequence: 2 givenname: Amy M. surname: Jean fullname: Jean, Amy M. – sequence: 3 givenname: Sarah K. surname: Zwany fullname: Zwany, Sarah K. – sequence: 4 givenname: Diana M. surname: Winston fullname: Winston, Diana M. – sequence: 5 givenname: Christy B. surname: Pomeranz fullname: Pomeranz, Christy B. – sequence: 6 givenname: Jennifer J. surname: Bell fullname: Bell, Jennifer J. – sequence: 7 givenname: Donald J. surname: McMahon fullname: McMahon, Donald J. – sequence: 8 givenname: Abeer surname: Hassoun fullname: Hassoun, Abeer – sequence: 9 givenname: Ilene surname: Fennoy fullname: Fennoy, Ilene – sequence: 10 givenname: Sharon E. surname: Oberfield fullname: Oberfield, Sharon E. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21311512$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1v1DAQxS1URD_gxhlFXLiwZfyRxOGA1K5aQKq0PYCAk-U4k11Xid3aTtH-93W0bQWV4GB5LP_m6c28Q7LnvENCXlM4psDlB99ujxnkF4fyGTmgDYdFzZufe4-1pPvkMMYrAFFBSV-QfUY5pSVlB-TmNKsVJ-t8ulvtDI7oUmFdcRnwemoxJD0Uy40duoCu-GHTpli1GG3aFtp1MzXqNIW5PQM6mA1-LC59jLYdMBcpy1mdrFsX59okH-JL8rzXQ8RX9_cR-X5-9m35ZXGx-vx1eXKxMIKKcqFpbwx2ElrDJTNNJXrdIhgAzvuaC92wsgJuTFdlVPYapKxEXQLrUNCm50fk0043jzFiZ7KRoAd1Heyow1Z5bdXfP85u1NrfKl7xGliVBd7dCwR_M2FMarTR4DBoh36KSlayrmQpIZNvn5BXfgouTzdDAqgUdYbe_Onn0chDFhlgO8CEvL-AvTI25dX52Z4dFAU1B65y4GoOXOXAc9P7J00Puv_A6Q7_bQfc_pdVq9NfjImS3wGFsL1u |
| CitedBy_id | crossref_primary_10_31362_patd_664874 crossref_primary_10_1097_MOP_0000000000000928 crossref_primary_10_1111_cen_14662 crossref_primary_10_1515_jpem_2021_0698 crossref_primary_10_5223_pghn_2020_23_1_89 crossref_primary_10_3389_fendo_2022_967711 crossref_primary_10_1002_jbmr_2914 crossref_primary_10_1109_TIM_2024_3381260 crossref_primary_10_1007_s12020_024_03988_w crossref_primary_10_1210_jendso_bvab173 crossref_primary_10_1186_s12887_020_02353_w crossref_primary_10_3390_children6050063 crossref_primary_10_1515_jpem_2021_0691 crossref_primary_10_6065_apem_2017_22_2_108 crossref_primary_10_1038_s41574_020_0336_x crossref_primary_10_1111_jcmm_18181 crossref_primary_10_1159_000467393 crossref_primary_10_1016_j_jsbmb_2014_06_004 crossref_primary_10_1111_cen_15108 crossref_primary_10_1016_j_ajodo_2023_05_022 crossref_primary_10_6065_apem_2018_23_4_210 crossref_primary_10_1016_j_cden_2021_06_009 crossref_primary_10_1038_s41390_024_03776_2 crossref_primary_10_1177_0009922815600437 crossref_primary_10_23736_S2724_5276_21_06543_5 crossref_primary_10_3390_jcm12062187 crossref_primary_10_1186_s12887_019_1755_5 crossref_primary_10_7570_jomes_2017_26_4_243 crossref_primary_10_1093_ejendo_lvae156 crossref_primary_10_3389_fped_2021_580314 crossref_primary_10_1097_BPO_0000000000002487 crossref_primary_10_1210_endrev_bnab009 crossref_primary_10_1210_jc_2012_3704 crossref_primary_10_1159_000369458 crossref_primary_10_1177_0009922812456238 crossref_primary_10_3389_fendo_2017_00291 crossref_primary_10_3945_ajcn_112_037325 crossref_primary_10_3389_fped_2023_1064177 crossref_primary_10_1038_s41598_024_52980_x crossref_primary_10_1186_s12887_020_02256_w crossref_primary_10_1016_j_ejrad_2023_110759 crossref_primary_10_1055_s_0041_1742259 crossref_primary_10_3346_jkms_2017_32_6_968 crossref_primary_10_4274_jcrpe_galenos_2022_2022_1_1 crossref_primary_10_1016_j_bone_2014_09_002 crossref_primary_10_1016_j_bone_2018_01_003 crossref_primary_10_1017_S0007114523000624 crossref_primary_10_1515_jpem_2019_0193 crossref_primary_10_1111_ijpo_13166 crossref_primary_10_3390_children10121905 crossref_primary_10_1089_trgh_2023_0246 crossref_primary_10_1111_apa_15617 crossref_primary_10_1159_000455968 crossref_primary_10_1210_jc_2014_1384 crossref_primary_10_4158_EP13193_OR crossref_primary_10_3389_fendo_2018_00375 crossref_primary_10_1159_000511873 crossref_primary_10_1530_EJE_11_0223 crossref_primary_10_1542_peds_2017_1486 crossref_primary_10_1007_s00431_022_04442_7 crossref_primary_10_3389_fendo_2022_850448 crossref_primary_10_3389_fendo_2022_1004114 crossref_primary_10_1055_s_0042_1744495 crossref_primary_10_1038_s41390_018_0096_7 crossref_primary_10_1210_clinem_dgac571 crossref_primary_10_1159_000516171 crossref_primary_10_1210_jc_2012_3888 crossref_primary_10_3390_nu14163260 crossref_primary_10_1002_jbmr_4313 crossref_primary_10_1007_s00247_019_04435_z crossref_primary_10_1139_apnm_2019_0046 crossref_primary_10_1530_EJE_12_0191 crossref_primary_10_1002_mrm_24439 crossref_primary_10_1038_s41598_022_19470_4 crossref_primary_10_1097_BPB_0000000000000485 crossref_primary_10_1210_jc_2014_1452 |
| Cites_doi | 10.1542/peds.2005-0664 10.1007/s00431-003-1358-9 10.1016/j.jpeds.2009.06.002 10.1530/eje.0.1460537 10.1016/j.jpeds.2008.12.038 10.1210/jc.2009-0314 10.1210/jcem.83.10.5204 10.1136/adc.44.235.291 10.1530/acta.0.0820342 10.1210/jc.74.2.254 10.1172/JCI117616 10.1056/NEJM199410203311604 10.1007/s00223-007-9071-8 10.1007/s11154-008-9102-4 10.2337/db06-0192 10.1159/000137661 10.1515/jpem-2000-s619 10.1136/adc.81.2.172 10.1067/mpd.2001.119446 10.1210/jc.2007-2614 10.1210/jc.86.6.2863 10.1515/JPEM.2006.19.9.1133 10.1016/j.mce.2006.04.008 10.1007/s00223-004-0161-6 10.1210/jc.86.11.5269 10.1210/jc.2007-0814 |
| ContentType | Journal Article |
| Copyright | 2011 North American Association for the Study of Obesity (NAASO) Copyright Nature Publishing Group Jun 2011 |
| Copyright_xml | – notice: 2011 North American Association for the Study of Obesity (NAASO) – notice: Copyright Nature Publishing Group Jun 2011 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM K9. 7X8 5PM |
| DOI | 10.1038/oby.2010.305 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE CrossRef MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1930-739X |
| EndPage | 1264 |
| ExternalDocumentID | PMC3637026 2357025471 21311512 10_1038_oby_2010_305 OBY2245 |
| Genre | article Journal Article Research Support, N.I.H., Extramural Feature |
| GrantInformation_xml | – fundername: NCRR NIH HHS grantid: RR00645 – fundername: NCRR NIH HHS grantid: 1UL1RR024156 – fundername: NCRR NIH HHS grantid: M01 RR000645 – fundername: NIDDK NIH HHS grantid: T32 DK065522 – fundername: NCRR NIH HHS grantid: UL1 RR024156 – fundername: National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK grantid: T32 DK065522 || DK |
| GroupedDBID | --- 05W 0R~ 123 1OC 29N 2FS 2WC 31~ 33P 39C 3SF 4.4 50Y 52U 52V 53G 70F 8-1 AAESR AAEVG AAFWJ AAHBH AAHQN AAIPD AAMMB AAMNL AANLZ AAONW AASGY AAWTL AAXRX AAYCA AAZKR ABCUV ABIVO ABJNI ABLJU ABQWH ABXGK ACAHQ ACCZN ACGFS ACGOF ACMXC ACPOU ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEFGJ AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFFPM AFGKR AFWVQ AFZJQ AGHNM AGXDD AGYGG AHBTC AHMBA AIACR AIDQK AIDYY AITYG AIURR ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AZVAB BAWUL BFHJK BHBCM BKNYI BMXJE BOGZA BPHCQ BRXPI BVXVI CS3 DCZOG DIK DPXWK DRFUL DRMAN DRSTM DU5 E3Z EBS EJD EMOBN F5P FUBAC G-S GODZA HGLYW HZ~ KBYEO LATKE LEEKS LH4 LITHE LOXES LUTES LW6 LYRES MEWTI MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM MY~ O66 O9- OK1 P2W PQQKQ PROAC R.K ROL SUPJJ WBKPD WHG WHWMO WIH WIJ WIK WIN WOHZO WOQ WQJ WVDHM WXSBR YHZ AAHHS AAYXX ACCFJ AEEZP AEQDE AIWBW AJBDE ALIPV CITATION CGR CUY CVF ECM EIF NPM K9. 7X8 5PM |
| ID | FETCH-LOGICAL-c4145-a1fcced80bc382c964fabe0c0033f734a925603ccd6a1f8fa088647502de419f3 |
| ISSN | 1930-7381 1930-739X |
| IngestDate | Thu Aug 21 14:32:06 EDT 2025 Thu Sep 04 17:53:51 EDT 2025 Fri Jul 25 23:54:53 EDT 2025 Mon Jul 21 05:49:54 EDT 2025 Thu Apr 24 23:04:13 EDT 2025 Tue Jul 01 01:16:06 EDT 2025 Wed Aug 20 07:27:36 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4145-a1fcced80bc382c964fabe0c0033f734a925603ccd6a1f8fa088647502de419f3 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| PMID | 21311512 |
| PQID | 868401847 |
| PQPubID | 105348 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3637026 proquest_miscellaneous_868768580 proquest_journals_868401847 pubmed_primary_21311512 crossref_citationtrail_10_1038_oby_2010_305 crossref_primary_10_1038_oby_2010_305 wiley_primary_10_1038_oby_2010_305_OBY2245 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | June 2011 |
| PublicationDateYYYYMMDD | 2011-06-01 |
| PublicationDate_xml | – month: 06 year: 2011 text: June 2011 |
| PublicationDecade | 2010 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: United States – name: Silver Spring |
| PublicationTitle | Obesity (Silver Spring, Md.) |
| PublicationTitleAlternate | Obesity (Silver Spring) |
| PublicationYear | 2011 |
| Publisher | Blackwell Publishing Ltd |
| Publisher_xml | – name: Blackwell Publishing Ltd |
| References | 1994; 331 2006; 55 2004; 163 1976; 82 1966; 7 2009; 154 2009; 155 2006; 19 2007; 92 1998; 83 1999; 81 2008; 70 2006; 117 2008; 93 2001; 86 1992; 74 2006; 254‐255 2009; 10 2000 2009; 94 2000; 13 2002; 146 1969; 44 2005; 76 2007; 81 1994; 94 2001; 139 1966 e_1_2_7_5_2 e_1_2_7_4_2 Prader A (e_1_2_7_14_2) 1966; 7 e_1_2_7_3_2 e_1_2_7_2_2 e_1_2_7_7_2 e_1_2_7_6_2 e_1_2_7_19_2 e_1_2_7_18_2 e_1_2_7_17_2 e_1_2_7_13_2 e_1_2_7_12_2 e_1_2_7_11_2 e_1_2_7_10_2 Grumbach MM (e_1_2_7_8_2) 2000; 13 e_1_2_7_26_2 e_1_2_7_27_2 e_1_2_7_28_2 e_1_2_7_29_2 Kuczmarski RJ (e_1_2_7_15_2) 2000 Greulich WW (e_1_2_7_16_2) 1966 e_1_2_7_25_2 e_1_2_7_24_2 e_1_2_7_30_2 e_1_2_7_23_2 e_1_2_7_22_2 e_1_2_7_21_2 e_1_2_7_20_2 Klein KO (e_1_2_7_9_2) 1998; 83 18812486 - J Clin Endocrinol Metab. 2008 Dec;93(12):4767-73 17882344 - Calcif Tissue Int. 2007 Oct;81(4):279-84 15868281 - Calcif Tissue Int. 2005 May;76(5):326-35 7989605 - J Clin Invest. 1994 Dec;94(6):2475-80 9768648 - J Clin Endocrinol Metab. 1998 Oct;83(10):3469-75 18821018 - Rev Endocr Metab Disord. 2009 Mar;10(1):3-17 11701690 - J Clin Endocrinol Metab. 2001 Nov;86(11):5269-72 19454583 - J Clin Endocrinol Metab. 2009 Aug;94(8):2835-40 14689304 - Eur J Pediatr. 2004 Feb;163(2):89-93 5785179 - Arch Dis Child. 1969 Jun;44(235):291-303 11397901 - J Clin Endocrinol Metab. 2001 Jun;86(6):2863-8 16396868 - Pediatrics. 2006 Jan;117(1):117-21 1730803 - J Clin Endocrinol Metab. 1992 Feb;74(2):254-7 8090165 - N Engl J Med. 1994 Oct 20;331(16):1056-61 19230905 - J Pediatr. 2009 Jun;154(6):882-7 11916623 - Eur J Endocrinol. 2002 Apr;146(4):537-43 10490531 - Arch Dis Child. 1999 Aug;81(2):172-3 17065341 - Diabetes. 2006 Nov;55(11):3047-52 5920758 - Triangle. 1966;7(6):240-3 11183293 - Adv Data. 2000 Jun 8;(314):1-27 16837127 - Mol Cell Endocrinol. 2006 Jul 25;254-255:202-6 17878253 - J Clin Endocrinol Metab. 2007 Dec;92(12):4873-7 179257 - Acta Endocrinol (Copenh). 1976 Jun;82(2):342-52 17128561 - J Pediatr Endocrinol Metab. 2006 Sep;19(9):1133-40 11202221 - J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1439-55 19643436 - J Pediatr. 2009 Dec;155(6):893-9 11743511 - J Pediatr. 2001 Dec;139(6):844-8 18663315 - Horm Res. 2008;70(3):150-4 |
| References_xml | – volume: 331 start-page: 1056 year: 1994 end-page: 1061 article-title: Estrogen resistance caused by a mutation in the estrogen‐receptor gene in a man publication-title: N Engl J Med – volume: 70 start-page: 150 year: 2008 end-page: 154 article-title: Characteristics of children with premature pubarche in the new york metropolitan area publication-title: Horm Res – volume: 55 start-page: 3047 year: 2006 end-page: 3052 article-title: Pubertal timing is an independent predictor of central adiposity in young adult males: the Gothenburg osteoporosis and obesity determinants study publication-title: Diabetes – volume: 82 start-page: 342 year: 1976 end-page: 352 article-title: Evidence for the adrenal source of androgens in precocious adrenarche publication-title: Acta Endocrinol – year: 1966 – volume: 154 start-page: 882 year: 2009 end-page: 887 article-title: Girls with premature adrenarche have accelerated early childhood growth publication-title: J Pediatr – volume: 74 start-page: 254 year: 1992 end-page: 257 article-title: Natural history of premature pubarche: an auxological study publication-title: J Clin Endocrinol Metab – volume: 163 start-page: 89 year: 2004 end-page: 93 article-title: Premature pubarche as an indicator of how body weight influences the onset of adrenarche publication-title: Eur J Pediatr – volume: 13 start-page: 1439 issue: Suppl 6 year: 2000 end-page: 1455 article-title: Estrogen, bone, growth and sex: a sea change in conventional wisdom publication-title: J Pediatr Endocrinol Metab – volume: 81 start-page: 279 year: 2007 end-page: 284 article-title: Anthropometric, bone age, and bone mineral density changes after a family based treatment for obese children publication-title: Calcif Tissue Int – volume: 92 start-page: 4873 year: 2007 end-page: 4877 article-title: GPR30 estrogen receptor expression in the growth plate declines as puberty progresses publication-title: J Clin Endocrinol Metab – volume: 155 start-page: 893 year: 2009 end-page: 899 article-title: Utility of early insulin response and proinsulin to assess insulin resistance publication-title: J Pediatr – volume: 94 start-page: 2835 year: 2009 end-page: 2840 article-title: Precocious pubarche: distinguishing late‐onset congenital adrenal hyperplasia from premature adrenarche publication-title: J Clin Endocrinol Metab – volume: 76 start-page: 326 year: 2005 end-page: 335 article-title: Localization of matrix metalloproteinases, (MMPs) their tissue inhibitors, and vascular endothelial growth factor (VEGF) in growth plates of children and adolescents indicates a role for MMPs in human postnatal growth and skeletal maturation publication-title: Calcif Tissue Int – start-page: 1 year: 2000 end-page: 27 article-title: CDC growth charts: United States publication-title: Adv Data – volume: 254‐255 start-page: 202 year: 2006 end-page: 206 article-title: Bone age and onset of puberty in normal boys publication-title: Mol Cell Endocrinol – volume: 94 start-page: 2475 year: 1994 end-page: 2480 article-title: Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay publication-title: J Clin Invest – volume: 19 start-page: 1133 year: 2006 end-page: 1140 article-title: Relationships of IGF‐I and androgens to skeletal maturation in obese children and adolescents publication-title: J Pediatr Endocrinol Metab – volume: 86 start-page: 2863 year: 2001 end-page: 2868 article-title: Comparison of simple measures of insulin sensitivity in young girls with premature adrenarche: the fasting glucose to insulin ratio may be a simple and useful measure publication-title: J Clin Endocrinol Metab – volume: 81 start-page: 172 year: 1999 end-page: 173 article-title: Bone age assessment: a large scale comparison of the Greulich and Pyle, and Tanner and Whitehouse (TW2) methods publication-title: Arch Dis Child – volume: 139 start-page: 844 year: 2001 end-page: 848 article-title: The relation between skeletal maturation and adiposity in African American and Caucasian children publication-title: J Pediatr – volume: 10 start-page: 3 year: 2009 end-page: 17 article-title: Androgen synthesis in adrenarche publication-title: Rev Endocr Metab Disord – volume: 93 start-page: 4767 year: 2008 end-page: 4773 article-title: Increases in bone mineral density in response to oral dehydroepiandrosterone replacement in older adults appear to be mediated by serum estrogens publication-title: J Clin Endocrinol Metab – volume: 7 start-page: 240 year: 1966 end-page: 243 article-title: Testicular size: assessment and clinical importance publication-title: Triangle – volume: 44 start-page: 291 year: 1969 end-page: 303 article-title: Variations in pattern of pubertal changes in girls publication-title: Arch Dis Child – volume: 83 start-page: 3469 year: 1998 end-page: 3475 article-title: Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children publication-title: J Clin Endocrinol Metab – volume: 86 start-page: 5269 year: 2001 end-page: 5272 article-title: Prepubertal girls with premature adrenarche have greater bone mineral content and density than controls publication-title: J Clin Endocrinol Metab – volume: 117 start-page: 117 year: 2006 end-page: 121 article-title: Early puberty‐menarche after precocious pubarche: relation to prenatal growth publication-title: Pediatrics – volume: 146 start-page: 537 year: 2002 end-page: 543 article-title: Associations between body mass, leptin, IGF‐I and circulating adrenal androgens in children with obesity and premature adrenarche publication-title: Eur J Endocrinol – ident: e_1_2_7_3_2 doi: 10.1542/peds.2005-0664 – volume-title: Radiographic Atlas of Skeletal Development of the Hand and Wrist year: 1966 ident: e_1_2_7_16_2 – ident: e_1_2_7_21_2 doi: 10.1007/s00431-003-1358-9 – ident: e_1_2_7_30_2 doi: 10.1016/j.jpeds.2009.06.002 – ident: e_1_2_7_20_2 doi: 10.1530/eje.0.1460537 – ident: e_1_2_7_6_2 doi: 10.1016/j.jpeds.2008.12.038 – ident: e_1_2_7_12_2 doi: 10.1210/jc.2009-0314 – volume: 83 start-page: 3469 year: 1998 ident: e_1_2_7_9_2 article-title: Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.83.10.5204 – ident: e_1_2_7_13_2 doi: 10.1136/adc.44.235.291 – ident: e_1_2_7_2_2 doi: 10.1530/acta.0.0820342 – volume: 7 start-page: 240 year: 1966 ident: e_1_2_7_14_2 article-title: Testicular size: assessment and clinical importance publication-title: Triangle – ident: e_1_2_7_5_2 doi: 10.1210/jc.74.2.254 – ident: e_1_2_7_25_2 doi: 10.1172/JCI117616 – ident: e_1_2_7_24_2 doi: 10.1056/NEJM199410203311604 – ident: e_1_2_7_22_2 doi: 10.1007/s00223-007-9071-8 – ident: e_1_2_7_19_2 doi: 10.1007/s11154-008-9102-4 – ident: e_1_2_7_29_2 doi: 10.2337/db06-0192 – ident: e_1_2_7_4_2 doi: 10.1159/000137661 – volume: 13 start-page: 1439 issue: 6 year: 2000 ident: e_1_2_7_8_2 article-title: Estrogen, bone, growth and sex: a sea change in conventional wisdom publication-title: J Pediatr Endocrinol Metab doi: 10.1515/jpem-2000-s619 – ident: e_1_2_7_27_2 doi: 10.1136/adc.81.2.172 – ident: e_1_2_7_10_2 doi: 10.1067/mpd.2001.119446 – ident: e_1_2_7_26_2 doi: 10.1210/jc.2007-2614 – start-page: 1 year: 2000 ident: e_1_2_7_15_2 article-title: CDC growth charts: United States publication-title: Adv Data – ident: e_1_2_7_17_2 doi: 10.1210/jc.86.6.2863 – ident: e_1_2_7_18_2 doi: 10.1515/JPEM.2006.19.9.1133 – ident: e_1_2_7_28_2 doi: 10.1016/j.mce.2006.04.008 – ident: e_1_2_7_7_2 doi: 10.1007/s00223-004-0161-6 – ident: e_1_2_7_11_2 doi: 10.1210/jc.86.11.5269 – ident: e_1_2_7_23_2 doi: 10.1210/jc.2007-0814 – reference: 7989605 - J Clin Invest. 1994 Dec;94(6):2475-80 – reference: 18821018 - Rev Endocr Metab Disord. 2009 Mar;10(1):3-17 – reference: 11183293 - Adv Data. 2000 Jun 8;(314):1-27 – reference: 11397901 - J Clin Endocrinol Metab. 2001 Jun;86(6):2863-8 – reference: 5920758 - Triangle. 1966;7(6):240-3 – reference: 18812486 - J Clin Endocrinol Metab. 2008 Dec;93(12):4767-73 – reference: 5785179 - Arch Dis Child. 1969 Jun;44(235):291-303 – reference: 17128561 - J Pediatr Endocrinol Metab. 2006 Sep;19(9):1133-40 – reference: 1730803 - J Clin Endocrinol Metab. 1992 Feb;74(2):254-7 – reference: 10490531 - Arch Dis Child. 1999 Aug;81(2):172-3 – reference: 19643436 - J Pediatr. 2009 Dec;155(6):893-9 – reference: 179257 - Acta Endocrinol (Copenh). 1976 Jun;82(2):342-52 – reference: 8090165 - N Engl J Med. 1994 Oct 20;331(16):1056-61 – reference: 17882344 - Calcif Tissue Int. 2007 Oct;81(4):279-84 – reference: 11701690 - J Clin Endocrinol Metab. 2001 Nov;86(11):5269-72 – reference: 17878253 - J Clin Endocrinol Metab. 2007 Dec;92(12):4873-7 – reference: 11202221 - J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1439-55 – reference: 14689304 - Eur J Pediatr. 2004 Feb;163(2):89-93 – reference: 16837127 - Mol Cell Endocrinol. 2006 Jul 25;254-255:202-6 – reference: 9768648 - J Clin Endocrinol Metab. 1998 Oct;83(10):3469-75 – reference: 18663315 - Horm Res. 2008;70(3):150-4 – reference: 19230905 - J Pediatr. 2009 Jun;154(6):882-7 – reference: 11743511 - J Pediatr. 2001 Dec;139(6):844-8 – reference: 15868281 - Calcif Tissue Int. 2005 May;76(5):326-35 – reference: 11916623 - Eur J Endocrinol. 2002 Apr;146(4):537-43 – reference: 17065341 - Diabetes. 2006 Nov;55(11):3047-52 – reference: 19454583 - J Clin Endocrinol Metab. 2009 Aug;94(8):2835-40 – reference: 16396868 - Pediatrics. 2006 Jan;117(1):117-21 |
| SSID | ssj0046051 |
| Score | 2.333082 |
| Snippet | Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal... |
| SourceID | pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1259 |
| SubjectTerms | Adrenal Glands - growth & development Age Determination by Skeleton Age Factors Body Mass Index Body Weight Bone density Bone Diseases, Developmental - epidemiology Child Child, Preschool Children & youth Cross-Sectional Studies Dehydroepiandrosterone Sulfate - blood Estradiol - blood Female Glycated Hemoglobin A - analysis Humans Insulin Resistance Male Obesity Obesity - blood Obesity - physiopathology Puberty Puberty, Precocious - etiology Severity of Illness Index Testosterone - blood United States - epidemiology |
| Title | Bone Age Advancement in Prepubertal Children With Obesity and Premature Adrenarche: Possible Potentiating Factors |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1038%2Foby.2010.305 https://www.ncbi.nlm.nih.gov/pubmed/21311512 https://www.proquest.com/docview/868401847 https://www.proquest.com/docview/868768580 https://pubmed.ncbi.nlm.nih.gov/PMC3637026 |
| Volume | 19 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZWRUJcEG9CAfkAF1ZZkth5mNsuUBWqBaS2auESJU4CkZYs0N2i8pv4kczYjtfLFlS4RIlj5zVfxuPx5xlCHsmCxxyUr9_UjPk4YvBFISo_kFkaVUKUIsC1w9M3ye4hf30cHw8GPx3W0nJRjuSPc9eV_I9UoQzkiqtk_0Gy9qJQAPsgX9iChGF7IRlP5mAijj-qtMooPTWx33bIq4DPjNPsMx27GFdrH6HH1eQBMGsEMF4rTiCMsYKK6oEOgndz_E9mNewskEtUKGb0jk7M4xqz_cXASN1vkWE91G5C5WStRo6TYV9FL1B66LQ9LYaTkWXu1NoDO_58Npza0g_fQUdZh_Vwz544arsTQ_h_AcAu-jbVyhHb86uMqhUs8FOmE7aMardMJddd6Wfh4NBVtmCbCafjDiMdD32jU9Ah4OflmWbysSBedX79hP9vfaJlKqo5epbl0DrH1jnDgLmXojTVpIBXe32_jxPMoeYw6Pcyyyyg9VP33usG0MaoZpOc6w6alNVzcI1cNcMVOtbYu04GdXeDXJ4aQsZN8hUhSAGC1IEgbTvqQJD2EKQIQWpQQwGC1EKQriD4jPYApC4AqQHgLXK48_Lg-a5vsnj4koc89ouwkbKusqCULIukSHhTlHUgMYtgkzJeCLS6mZRVAlWzpoB-L-FgyEZVzUPRsNtkq4N3uUtoUoowK1kWJ7LkSQIts4rBd03hiEsWeGTYf9pcmhD3mGlllp8nRo88trW_6NAuf6i33UspNz__SZ5hkKQQTDuPUHsWNDNOtxVdPV-qKilmd4DHuqNFam8TqSBXYeSRdE3YtgIGfV8_07WfVPB3lrA0iBKPPFGw-OuT528n78FEj-9d8E23yZXVn3qfbC2-LesHYHMvyocK6r8AIzPVQQ |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Bone+Age+Advancement+in+Prepubertal+Children+With+Obesity+and+Premature+Adrenarche%3A+Possible+Potentiating+Factors&rft.jtitle=Obesity+%28Silver+Spring%2C+Md.%29&rft.au=Sopher%2C+Aviva+B.&rft.au=Jean%2C+Amy+M.&rft.au=Zwany%2C+Sarah+K.&rft.au=Winston%2C+Diana+M.&rft.date=2011-06-01&rft.issn=1930-7381&rft.eissn=1930-739X&rft.volume=19&rft.issue=6&rft.spage=1259&rft.epage=1264&rft_id=info:doi/10.1038%2Foby.2010.305&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_oby_2010_305 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1930-7381&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1930-7381&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1930-7381&client=summon |