Thieno[2,3-d]pyrimidines in the Synthesis of Antitumor and Antioxidant Agents

• Published in: Archiv der Pharmazie (Weinheim) Vol. 343; no. 5; pp. 301 - 309
• Main Authors: Aly, Ashraf A., Brown, Alan B., Ramadan, Mohamed, Gamal-Eldeen, Amira M., Abdel-Aziz, Mohamed, Abuo-Rahma, Gamal El-Din A. A., Radwan, Mohamed F.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.05.2010; WILEY‐VCH Verlag; Wiley
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Antioxidants - chemical synthesis; Antioxidants - pharmacology; Antitumor activity; Biphenyl Compounds - antagonists & inhibitors; Cell Proliferation - drug effects; Cells, Cultured; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Cyclization; Dimethyl acetylenedicarboxylate; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor - methods; E-Dibenzoylethylene; HCT116 Cells; Hep G2 Cells; Humans; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Physical Sciences; Picrates - antagonists & inhibitors; Pyrimidines - chemical synthesis; Pyrimidines - chemistry; Pyrimidines - pharmacology; Science & Technology; Structure-Activity Relationship; Thienopyrimidines; ACID-DERIVATIVES; E-Dibenzoylethylene; Cyclization; GROWTH; PYRIMIDINES; Antitumor activity; Dimethyl acetylenedicarboxylate; Thienopyrimidines; PHARMACOLOGICAL ACTIVITIES

Dimethyl acetylenedicarboxylate, ethyl propiolate, and E‐dibenzoylethylene react with thienopyrimidines (cyclo‐pentyl, ‐hexyl, and ‐heptyl) derivatives to form thiazolo[3,2‐a]thieno‐[2,3‐d]pyrimidin‐2‐ylidene) acetates, thieno[2,3‐d]pyrimidin‐2‐ylthioacrylates, and thieno[2′,3′:4,5]pyrimido[2,1‐b][1...