Genetics of resistance to the African trypanosomes. VI. Heredity of resistance and variable surface glycoprotein-specific immune responses

• Published in: The Journal of immunology (1950) Vol. 140; no. 1; pp. 283 - 288
• Main Authors: De Gee, AL, Levine, RF, Mansfield, JM
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Assoc Immnol 01.01.1988; American Association of Immunologists
• Subjects: Animals; Antibodies, Protozoan - immunology; B-Lymphocytes - immunology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Genes, Dominant; Genes, MHC Class II; Genes, Recessive; Human protozoal diseases; Immunity, Innate; Infectious diseases; Life cycle. Host-agent relationship. Pathogenesis; Medical sciences; Mice; Mice, Inbred Strains; Parasitic diseases; Protozoa; Protozoal diseases; Tropical medicine; Trypanosoma brucei brucei - immunology; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African - genetics; Trypanosomiasis, African - immunology; Trypanosomiasis, African - parasitology; Variant Surface Glycoproteins, Trypanosoma - immunology; Host parasite relation; Protozoal disease; Inheritance; Cell surface; Intraspecific comparison; Parasitemia; Trypanosomiasis; Humoral immunity; Protozoa; Rodentia; Hybrid; Glycoproteins; Parasitosis; African sickness; Long term; Survival; Infection; Antigen; Resistance; Vertebrata; Dominance recessiveness; Experimental disease; Mammalia; Sensitivity resistance; Mouse; Trypanosoma rhodesiense; Antigenic variation; Rhizoflagellata; Inbred

The question of genetic linkage of parasite-specific immune responses to resistance to infection in experimental African trypanosomiasis was addressed. For this purpose, major histocompatibility complex-compatible resistant and susceptible inbred mouse strains and their F1 hybrid, F2 hybrid, and bac...