miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease

• Published in: Circulation research Vol. 120; no. 2; pp. 354 - 365
• Main Authors: He, Ming, Chen, Zhen, Martin, Marcy, Zhang, Jin, Sangwung, Panjamaporn, Woo, Brian, Tremoulet, Adriana H., Shimizu, Chisato, Jain, Mukesh K., Burns, Jane C., Shyy, John Y.-J.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 20.01.2017
• Subjects: Animals; Atorvastatin - administration & dosage; Cattle; Child, Preschool; Connective Tissue Growth Factor - biosynthesis; Connective Tissue Growth Factor - genetics; Dose-Response Relationship, Drug; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - physiology; Female; Gene Targeting - methods; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - physiology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Infant; Kruppel-Like Factor 4; Male; Mice; Mice, Transgenic; MicroRNAs - administration & dosage; MicroRNAs - biosynthesis; MicroRNAs - genetics; Mucocutaneous Lymph Node Syndrome - blood; Mucocutaneous Lymph Node Syndrome - genetics; Mucocutaneous Lymph Node Syndrome - therapy; EndoMT; Kawasaki disease; miR-483; microRNA; atorvastatin; endothelial dysfunction; CTGF

RATIONALE:Endothelial–mesenchymal transition (EndoMT) is implicated in myofibroblast-like cell–mediated damage to the coronary arterial wall in acute Kawasaki disease (KD) patients, as evidenced by positive staining for connective tissue growth factor (CTGF) and EndoMT markers in KD autopsy tissues....