miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease - He, Ming; Chen, Zhen; Martin, Marcy; Zhang, Jin; Sangwung, Panjamaporn; Woo, Brian; Tremoulet, Adriana H.; Shimizu, Chisato; Jain, Mukesh K.; Burns, Jane C.; Shyy, John Y.-J. (Circulation research, 2017)
Keywords: Animals; Atorvastatin - administration & dosage; Cattle; Child, Preschool; Connective Tissue Growth Factor - biosynthesis; Connective Tissue Growth Factor - genetics; Dose-Response Relationship, Drug; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - physiology; Female; Gene Targeting - methods; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - physiology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Infant; Kruppel-Like Factor 4; Male; Mice; Mice, Transgenic; MicroRNAs - administration & dosage; MicroRNAs - biosynthesis; MicroRNAs - genetics; Mucocutaneous Lymph Node Syndrome - blood; Mucocutaneous Lymph Node Syndrome - genetics; Mucocutaneous Lymph Node Syndrome - therapy; EndoMT; Kawasaki disease; miR-483; microRNA; atorvastatin; endothelial dysfunction; CTGF