A systematic review and meta‐analysis of the impacts of germline pharmacogenomics on severe toxicity and symptom burden in adult patients with cancer

• Published in: Clinical and translational science Vol. 17; no. 5; pp. e13781 - n/a
• Main Authors: Lingaratnam, Senthil, Shah, Mahek, Nicolazzo, Joseph, Michael, Michael, Seymour, John F., James, Paul, Lazarakis, Smaro, Loi, Sherene, Kirkpatrick, Carl M. J.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.05.2024; Wiley
• Subjects: Adult; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Cancer; Cancer therapies; Clinical trials; Comparative studies; Drb1 protein; Genes; Germ-Line Mutation; Humans; Medicine; Meta-analysis; Neoplasms - drug therapy; Neoplasms - genetics; Patient safety; Pharmacogenetics; Pharmacogenomic Testing; Pharmacogenomic Variants; Pharmacogenomics; Safety; Subject heading schemes; Symptom Burden; Systematic review; Toxicity

The clinical application of Pharmacogenomics (PGx) has improved patient safety. However, comprehensive PGx testing has not been widely adopted in clinical practice, and significant opportunities exist to further optimize PGx in cancer care. This systematic review and meta‐analysis aim to evaluate th...