Leptin receptor signaling mediates the distinct tendon–bone interface reconstruction in rotator cuff tears and osteoporosis-comorbid rotator cuff tears

• Published in: Stem cell research & therapy Vol. 16; no. 1; pp. 1 - 14
• Main Authors: Zhu, Dongxu, Zhu, Xinrui, Zhang, Yingze, Huang, Xiaohong
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 22.08.2025; BioMed Central; BMC
• Subjects: Analysis; Angiopoietin like 4; Cellular signal transduction; Comorbidity; Ethylenediaminetetraacetic acid; Leptin; Leptin receptor; Orthopedic surgery; Osteoporosis; Rotator cuff tears; Tendon–bone interface; China

Background The intact tendon-bone interface (TBI) consists of four histological layers--tendon, fibrocartilage, calcified fibrocartilage, and bone--that gradually merge into each other, making complete structural restoration after injury challenging. Osteoporosis poses a significant risk for rotator...