Substantial role of locus coeruleus-noradrenergic activation and capsaicin-insensitive primary afferent fibers in bee venom's anti-inflammatory effect

• Published in: Neuroscience research Vol. 55; no. 2; pp. 197 - 203
• Main Authors: Kwon, Young Bae, Yoon, Seo Yeon, Kim, Hyun Woo, Roh, Dae Hyun, Kang, Seuk Yun, Ryu, Yeon Hee, Choi, Sun Mi, Han, Ho Jae, Lee, Hye Jung, Kim, Kee Won, Beitz, Alvin J., Lee, Jang Hern
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.06.2006
• Subjects: Adrenergic Agents - pharmacology; Animals; Anti-Inflammatory Agents - therapeutic use; Bee venom; Bee Venoms - therapeutic use; Capsaicin - pharmacology; Capsaicin-sensitive primary afferent fibers; Disease Models, Animal; Diterpenes - pharmacology; Drug Interactions; Fos; Functional Laterality; Gene Expression - drug effects; Inflammation; Inflammation - chemically induced; Inflammation - drug therapy; Leukocytes - drug effects; Leukocytes - physiology; Locus coeruleus; Locus Coeruleus - drug effects; Locus Coeruleus - metabolism; Mice; Mice, Inbred ICR; Norepinephrine - metabolism; Oncogene Proteins v-fos - metabolism; Oxidopamine - pharmacology; Sciatic Neuropathy - diet therapy; Sciatic Neuropathy - pathology; Sciatic Neuropathy - physiopathology; Zymosan; Inflammation; Capsaicin-sensitive primary afferent fibers; Fos; Bee venom; Locus coeruleus

Several lines of evidence indicate significant interactions between the immune and nervous systems. Our recent study reveals that ‘bee venom (BV) induced anti-inflammatory effect’ (BVAI) was produced by sympathetic preganglionic neuronal activation and subsequent adrenomedullary catecholamine releas...