S-Methyl methane thiosulfonate, a new antimutagenic compound isolated from Brassica oleracea L. var. botrytis

• Published in: Biological & pharmaceutical bulletin Vol. 16; no. 2; pp. 207 - 209
• Main Authors: NAKAMURA, Yasushi, MATSUO, Tomoaki, SHIMOI, Kayoko, NAKAMURA, Yoshiyuki, TOMITA, Isao
• Format: Journal Article
• Language: English
• Published: Tokyo Maruzen 01.02.1993
• Subjects: Antimutagenic Agents - chemistry; Antimutagenic Agents - isolation & purification; Antimutagenic Agents - pharmacology; Biological and medical sciences; Brassica - chemistry; Escherichia coli - drug effects; Escherichia coli - genetics; Escherichia coli - radiation effects; General pharmacology; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medical sciences; Methyl Methanesulfonate - analogs & derivatives; Methyl Methanesulfonate - chemistry; Methyl Methanesulfonate - isolation & purification; Methyl Methanesulfonate - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Ultraviolet Rays; Methane derivatives; Antimutagen; Pharmacognosy; Mutagenicity testing; Escherichia coli; Thiosulfonate; Extract; In vitro; Brassica oleracea; Cruciferae; Dicotyledones; Angiospermae; Plant origin; Microorganism culture; Bacteria; Isolation; Active ingredient; Spermatophyta; Enterobacteriaceae
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.16.207

Though various antimutagens with desmutagenic activities have been found in our daily foods of plant origin, the numbers of antimutagens with bio-antimutagenic activities found so far are limited. In the present study, a compound with potential bio-antimutagenic activity to Escherichia coli B/r WP2 was newly isolated from cauliflower, Brassica oleracea L. var. botrytis, and its chemical structure was identified to be S-methyl methane thiosulfonate by NMR and MS analysis.