Noninvasive Diagnosis of Bladder Cancer by Detection of Matrix Metalloproteinases (MMP-2 and MMP-9) and Their Inhibitor (TIMP-2) in Urine

• Published in: European urology Vol. 52; no. 5; pp. 1388 - 1397
• Main Authors: Eissa, Sanaa, Ali-Labib, Randa, Swellam, Menha, Bassiony, Manal, Tash, Fathy, El-Zayat, Tarek Mostafa
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.11.2007
• Subjects: Adult; Aged; Aged, 80 and over; Bilharziasis; Biomarkers, Tumor - urine; Bladder cancer; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - enzymology; Carcinoma, Transitional Cell - diagnosis; Carcinoma, Transitional Cell - enzymology; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Matrix Metalloproteinase 2 - urine; Matrix Metalloproteinase 9 - urine; Matrix metalloproteinases; Middle Aged; MMP-2; MMP-9; Prognosis; Prospective Studies; ROC Curve; Severity of Illness Index; TIMP-2; Tissue Inhibitor of Metalloproteinase-2 - urine; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - enzymology; Urine markers; Urology; Bilharziasis; TIMP-2; Matrix metalloproteinases; MMP-2; Urine markers; MMP-9; Bladder cancer

TIMPs control the activity of MMPs, one of the key molecules for tumor invasion and metastasis. The aim of this study was to assess the usefulness of MMP-2 and MMP-9 in relation to their inhibitor (TIMP2) as noninvasive diagnostic tests for bilharzial bladder cancer. Voided urine samples were provid...