Staphylococcus aureus nasal carriage in a student community: prevalence, clonal relationships, and risk factors
To evaluate the prevalence and risk factors of nasal Staphylococcus aureus (SA) in the community. Cross-sectional study. Wake Forest University, Winston-Salem, North Carolina. Four hundred fifty students were screened for nasal SA carriage during the fall of 2000, 2001, and 2002. Students were scree...
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Published in | Infection control and hospital epidemiology Vol. 25; no. 6; p. 485 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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United States
01.06.2004
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Abstract | To evaluate the prevalence and risk factors of nasal Staphylococcus aureus (SA) in the community.
Cross-sectional study.
Wake Forest University, Winston-Salem, North Carolina.
Four hundred fifty students were screened for nasal SA carriage during the fall of 2000, 2001, and 2002.
Students were screened by nose swabs. A self-administered questionnaire collected information on demographics and medical history. Antibiotic testing and PFGE were performed on isolates. Risk factors were determined by logistic regression analysis.
Of 450 volunteers, 131 (29%) were SA carriers. Antibiotic resistance was high for azithromycin (26%) and low for ciprofloxacin (1%), tetracycline (5%), mupirocin (1%), and methicillin (2%). PFGE patterns were not associated with carriage. Age, male gender, white race, medical student, allergen injection therapy, chronic sinusitis, rheumatoid arthritis, hospitalization for 6 months or less, and use of antibiotics were associated with carrier status by univariate analysis. Stepwise multivariate logistic regression led to a best fitting model with older age (OR, 1.04; CI95, 1.005-1.079), male gender (OR, 1.50; CI95, 0.982-2.296), and chronic sinusitis (OR, 2.71; CI95, 0.897-8.195) as risk factors. Antibiotic use (< 4 weeks) (OR, 0.41; CI95, 0.152-1.095) and allergen injection therapy (OR, 0.41; CI95, 0.133-1.238) were protective. Analyses of carriers revealed candidate factors for persistent carriage to be nasal SA colonization rate and male gender. Factors for azithromycin resistance were non-medical students and antibiotic use in the past 6 months.
Older male volunteers suffering from chronic sinusitis and not taking antibiotics were at higher risk for carrying SA. |
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AbstractList | To evaluate the prevalence and risk factors of nasal Staphylococcus aureus (SA) in the community.
Cross-sectional study.
Wake Forest University, Winston-Salem, North Carolina.
Four hundred fifty students were screened for nasal SA carriage during the fall of 2000, 2001, and 2002.
Students were screened by nose swabs. A self-administered questionnaire collected information on demographics and medical history. Antibiotic testing and PFGE were performed on isolates. Risk factors were determined by logistic regression analysis.
Of 450 volunteers, 131 (29%) were SA carriers. Antibiotic resistance was high for azithromycin (26%) and low for ciprofloxacin (1%), tetracycline (5%), mupirocin (1%), and methicillin (2%). PFGE patterns were not associated with carriage. Age, male gender, white race, medical student, allergen injection therapy, chronic sinusitis, rheumatoid arthritis, hospitalization for 6 months or less, and use of antibiotics were associated with carrier status by univariate analysis. Stepwise multivariate logistic regression led to a best fitting model with older age (OR, 1.04; CI95, 1.005-1.079), male gender (OR, 1.50; CI95, 0.982-2.296), and chronic sinusitis (OR, 2.71; CI95, 0.897-8.195) as risk factors. Antibiotic use (< 4 weeks) (OR, 0.41; CI95, 0.152-1.095) and allergen injection therapy (OR, 0.41; CI95, 0.133-1.238) were protective. Analyses of carriers revealed candidate factors for persistent carriage to be nasal SA colonization rate and male gender. Factors for azithromycin resistance were non-medical students and antibiotic use in the past 6 months.
Older male volunteers suffering from chronic sinusitis and not taking antibiotics were at higher risk for carrying SA. |
Author | Tucker, Keith B Sherertz, Robert J Wallis, Michelle L Bischoff, Werner E Reboussin, Beth A |
Author_xml | – sequence: 1 givenname: Werner E surname: Bischoff fullname: Bischoff, Werner E organization: Department of Internal Medicine, Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA – sequence: 2 givenname: Michelle L surname: Wallis fullname: Wallis, Michelle L – sequence: 3 givenname: Keith B surname: Tucker fullname: Tucker, Keith B – sequence: 4 givenname: Beth A surname: Reboussin fullname: Reboussin, Beth A – sequence: 5 givenname: Robert J surname: Sherertz fullname: Sherertz, Robert J |
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Snippet | To evaluate the prevalence and risk factors of nasal Staphylococcus aureus (SA) in the community.
Cross-sectional study.
Wake Forest University, Winston-Salem,... |
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SubjectTerms | Adult Age Factors Carrier State - epidemiology Carrier State - microbiology Cross-Sectional Studies Drug Resistance, Bacterial Female Humans Logistic Models Male Methicillin Resistance Nasal Mucosa - microbiology North Carolina - epidemiology Prevalence Risk Factors Sex Factors Staphylococcal Infections - epidemiology Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Students Surveys and Questionnaires Universities |
Title | Staphylococcus aureus nasal carriage in a student community: prevalence, clonal relationships, and risk factors |
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