High-dimensional phenotyping of the peripheral immune response in community-acquired pneumonia

• Published in: Frontiers in immunology Vol. 14; p. 1260283
• Main Authors: Reijnders, Tom D. Y., Schuurman, Alex R., Verhoeff, Jan, van den Braber, Marlous, Douma, Renée A., Faber, Daniël R., Paul, Alberta G. A., Wiersinga, W. Joost, Saris, Anno, Garcia Vallejo, Juan J., van der Poll, Tom
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2023
• Subjects: Adult; Community-Acquired Infections; COVID-19; host response; Humans; Immunity; immunophenotyping; Leukocytes, Mononuclear; monocytes; Pneumonia; Receptors, CCR7; spectral flow cytometry; COVID-19; host response; monocytes; chemokine receptors; pneumonia; immunophenotyping; immunosuppression; spectral flow cytometry

Community-acquired pneumonia (CAP) represents a major health burden worldwide. Dysregulation of the immune response plays an important role in adverse outcomes in patients with CAP. We analyzed peripheral blood mononuclear cells by 36-color spectral flow cytometry in adult patients hospitalized for...