β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion

β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor- and retinoid X receptor-...

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Published inProceedings of the Nutrition Society Vol. 78; no. 1; pp. 68 - 87
Main Authors Bohn, Torsten, Desmarchelier, Charles, El, Sedef N., Keijer, Jaap, van Schothorst, Evert, Rühl, Ralph, Borel, Patrick
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.02.2019
Cambridge University Press (CUP)
Subjects
beta Carotene - metabolism
beta-carotene
bioactive properties
Bioavailability
Biological activity
Biological Availability
blood serum
Carotene
Carotenoids
chronic diseases
Conference on ‘Nutrient–nutrient interaction’
critical control points
Diabetes
Digestion - physiology
Enzymes
Esters
Excretion
Fatty acids
Food
Food and Nutrition
Gene expression
genes
hormone receptors
Human body
Human subjects
Humans
Life Sciences
Ligands
Lipids
Metabolic Networks and Pathways - physiology
Metabolism
Metabolites
Nuclear receptors
Nutrition Society Scottish Section Meeting 2018
Oxygenase
Particle size
Physiology
Receptors
Retinoic acid
retinoic acid receptors
Retinoids
Signal transduction
Signaling
Studies
Symposium 2: Nutrient interactions and their role in protection from chronic diseases
tissue distribution
Tissue Distribution - physiology
Vitamin A
β-Carotene
Vitamin A
Nuclear hormone receptor
Absorption
SNPs
Apo-carotenoids
Micellisation
Retinoic acid
Online AccessGet full text

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Abstract β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor- and retinoid X receptor-mediated signalling. To better understand the metabolic conversion of β-carotene, inter-individual differences regarding β-carotene bioavailability and bioactivity are key steps that determine its further metabolism and bioactivation and mediated signalling. Major carotenoid metabolites, the retinoids, can be stored as esters or further oxidised and excreted via phase 2 metabolism pathways. In this review, we aim to highlight the major critical control points that determine the fate of β-carotene in the human body, with a special emphasis on β-carotene oxygenase 1. The hypothesis that higher dietary β-carotene intake and serum level results in higher β-carotene-mediated signalling is partly questioned. Alternative autoregulatory mechanisms in β-carotene / retinoid-mediated signalling are highlighted to better predict and optimise nutritional strategies involving β-carotene-related health beneficial mediated effects.
AbstractList β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor- and retinoid X receptor-mediated signalling. To better understand the metabolic conversion of β-carotene, inter-individual differences regarding β-carotene bioavailability and bioactivity are key steps that determine its further metabolism and bioactivation and mediated signalling. Major carotenoid metabolites, the retinoids, can be stored as esters or further oxidised and excreted via phase 2 metabolism pathways. In this review, we aim to highlight the major critical control points that determine the fate of β-carotene in the human body, with a special emphasis on β-carotene oxygenase 1. The hypothesis that higher dietary β-carotene intake and serum level results in higher β-carotene-mediated signalling is partly questioned. Alternative autoregulatory mechanisms in β-carotene / retinoid-mediated signalling are highlighted to better predict and optimise nutritional strategies involving β-carotene-related health beneficial mediated effects.
β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor- and retinoid X receptor-mediated signalling. To better understand the metabolic conversion of β-carotene, inter-individual differences regarding β-carotene bioavailability and bioactivity are key steps that determine its further metabolism and bioactivation and mediated signalling. Major carotenoid metabolites, the retinoids, can be stored as esters or further oxidised and excreted via phase 2 metabolism pathways. In this review, we aim to highlight the major critical control points that determine the fate of β-carotene in the human body, with a special emphasis on β-carotene oxygenase 1. The hypothesis that higher dietary β-carotene intake and serum level results in higher β-carotene-mediated signalling is partly questioned. Alternative autoregulatory mechanisms in β-carotene / retinoid-mediated signalling are highlighted to better predict and optimise nutritional strategies involving β-carotene-related health beneficial mediated effects.β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor- and retinoid X receptor-mediated signalling. To better understand the metabolic conversion of β-carotene, inter-individual differences regarding β-carotene bioavailability and bioactivity are key steps that determine its further metabolism and bioactivation and mediated signalling. Major carotenoid metabolites, the retinoids, can be stored as esters or further oxidised and excreted via phase 2 metabolism pathways. In this review, we aim to highlight the major critical control points that determine the fate of β-carotene in the human body, with a special emphasis on β-carotene oxygenase 1. The hypothesis that higher dietary β-carotene intake and serum level results in higher β-carotene-mediated signalling is partly questioned. Alternative autoregulatory mechanisms in β-carotene / retinoid-mediated signalling are highlighted to better predict and optimise nutritional strategies involving β-carotene-related health beneficial mediated effects.
β-Carotene intake and tissue/blood concentrations have been associated with reduced inci-dence of several chronic diseases. Further bioactive carotenoid-metabolites can modulatethe expression of specific genes mainly via the nuclear hormone receptors: retinoic acidreceptor- and retinoid X receptor-mediated signalling. To better understand the metabolicconversion of β-carotene, inter-individual differences regarding β-carotene bioavailabilityand bioactivity are key steps that determine its further metabolism and bioactivation andmediated signalling. Major carotenoid metabolites, the retinoids, can be stored as estersor further oxidised and excreted via phase 2 metabolism pathways. In this review, we aimto highlight the major critical control points that determine the fate of β-carotene in thehuman body, with a special emphasis on β-carotene oxygenase 1. The hypothesis that higherdietary β-carotene intake and serum level results in higher β-carotene-mediated signalling ispartly questioned. Alternative autoregulatory mechanisms in β-carotene / retinoid-mediatedsignalling are highlighted to better predict and optimise nutritional strategies involving β-carotene-related health beneficial mediated effects.
Author Keijer, Jaap
Desmarchelier, Charles
Rühl, Ralph
van Schothorst, Evert
Bohn, Torsten
El, Sedef N.
Borel, Patrick
Author_xml – sequence: 1
  givenname: Torsten
  surname: Bohn
  fullname: Bohn, Torsten
  organization: 1Luxembourg Institute of Health, rue 1 A-B Thomas Edison, L-1445 Strassen, Luxembourg
– sequence: 2
  givenname: Charles
  surname: Desmarchelier
  fullname: Desmarchelier, Charles
  organization: 2C2VN, Aix-Marseille Univ., INRA, INSERM, Marseille, France
– sequence: 3
  givenname: Sedef N.
  surname: El
  fullname: El, Sedef N.
  organization: 3Engineering Faculty, Food Engineering Department, Ege University, Izmir, Turkey
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  givenname: Jaap
  surname: Keijer
  fullname: Keijer, Jaap
  organization: 4Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands
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  givenname: Evert
  surname: van Schothorst
  fullname: van Schothorst, Evert
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  organization: 5Paprika Bioanalytics BT, Debrecen, Hungary
– sequence: 7
  givenname: Patrick
  orcidid: 0000-0001-9977-3238
  surname: Borel
  fullname: Borel, Patrick
  organization: 2C2VN, Aix-Marseille Univ., INRA, INSERM, Marseille, France
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Issue 1
Keywords Vitamin A
Nuclear hormone receptor
Absorption
SNPs
Apo-carotenoids
Micellisation
Retinoic acid
Language English
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Snippet β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive...
β-Carotene intake and tissue/blood concentrations have been associated with reduced inci-dence of several chronic diseases. Further bioactive...
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SubjectTerms beta Carotene - metabolism
beta-carotene
bioactive properties
Bioavailability
Biological activity
Biological Availability
blood serum
Carotene
Carotenoids
chronic diseases
Conference on ‘Nutrient–nutrient interaction’
critical control points
Diabetes
Digestion - physiology
Enzymes
Esters
Excretion
Fatty acids
Food
Food and Nutrition
Gene expression
genes
hormone receptors
Human body
Human subjects
Humans
Life Sciences
Ligands
Lipids
Metabolic Networks and Pathways - physiology
Metabolism
Metabolites
Nuclear receptors
Nutrition Society Scottish Section Meeting 2018
Oxygenase
Particle size
Physiology
Receptors
Retinoic acid
retinoic acid receptors
Retinoids
Signal transduction
Signaling
Studies
Symposium 2: Nutrient interactions and their role in protection from chronic diseases
tissue distribution
Tissue Distribution - physiology
Vitamin A
β-Carotene
Title β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion
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https://amu.hal.science/hal-02487119
Volume 78
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