Short communication: Effect of supplementation with Lactobacillus casei Shirota on insulin sensitivity, β-cell function, and markers of endothelial function and inflammation in subjects with metabolic syndrome—A pilot study

• Published in: Journal of dairy science Vol. 96; no. 1; pp. 89 - 95
• Main Authors: Tripolt, N.J., Leber, B., Blattl, D., Eder, M., Wonisch, W., Scharnagl, H., Stojakovic, T., Obermayer-Pietsch, B., Wascher, T.C., Pieber, T.R., Stadlbauer, V., Sourij, H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2013
• Subjects: animals; bacteria; blood; cell adhesion; Dietary Supplements; drug effects; drug therapy; endothelial function; Endothelium, Vascular; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; fasting; Glucose Tolerance Test; glucose tolerance tests; homeostasis; Humans; inflammation; Inflammation - drug therapy; insulin resistance; Insulin Resistance - physiology; insulin secretion; insulin sensitivity; Insulin-Secreting Cells; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - physiology; Lacticaseibacillus casei; Lactobacillus casei; Lactobacillus casei - metabolism; Lactobacillus casei Shirota; Male; metabolic syndrome; Metabolic Syndrome - drug therapy; metabolism; Middle Aged; pharmacology; physiology; Pilot Projects; probiotics; Probiotics - pharmacology; therapeutics; metabolic syndrome; endothelial function; insulin sensitivity; Lactobacillus casei Shirota

Based on animal studies, intake of probiotic bacteria was suggested to improve insulin sensitivity by reducing endotoxinemia and inflammation. The objective of this study was to determine the effects of supplementation with the probiotic strain Lactobacillus casei Shirota (LcS) over 12wk on insulin...