Metabolic syndrome but not genetic polymorphisms known to induce NAFLD predicts increased total mortality in subjects with NAFLD (OPERA study)

• Published in: Scandinavian journal of clinical and laboratory investigation Vol. 80; no. 2; pp. 106 - 113
• Main Authors: Käräjämäki, Aki Juhani, Hukkanen, Janne, Kauma, Heikki, Kesäniemi, Y. Antero, Ukkola, Olavi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.02.2020
• Subjects: Acyltransferases - genetics; Adult; cardiovascular disease; Cardiovascular Diseases - genetics; Cardiovascular Diseases - mortality; Case-Control Studies; Female; Finland - epidemiology; Genetic Predisposition to Disease; Humans; Lipase - genetics; Male; MBOAT7; Membrane Proteins - genetics; metabolic syndrome; Metabolic Syndrome - etiology; Metabolic Syndrome - genetics; Middle Aged; mortality; Non-alcoholic fatty liver disease; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - mortality; PNPLA3; Polymorphism, Single Nucleotide; Risk Factors; TM6SF2; Finland; metabolic syndrome; cardiovascular disease; MBOAT7; PNPLA3; mortality; Non-alcoholic fatty liver disease; TM6SF2

Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs58542926 and MBOAT7 rs641738 are known inductors of non-alcoholic fatty liver disease (NAFLD). However, knowledge about how these affect the mortality of subjects with NAFLD is scarce. Therefore, we investigated the impact...