Reference dose (RfD): description and use in health risk assessments

• Published in: Regulatory toxicology and pharmacology Vol. 8; no. 4; p. 471
• Main Authors: Barnes, D G, Dourson, M
• Format: Journal Article
• Language: English
• Published: Netherlands 01.12.1988
• Subjects: Animals; Dose-Response Relationship, Drug; Environmental Pollutants - toxicity; Reference Standards; United States; United States Environmental Protection Agency; United States

For many years the concept of the "acceptable daily intake" has served the toxicological and regulatory fields quite well. However, as approaches to assessing the health significance of exposures to noncarcinogenic substances receive greater scrutiny, some difficulties with this traditiona...