Advances in mRNA-based drug discovery in cancer immunotherapy

• Published in: Expert opinion on drug discovery Vol. 17; no. 1; p. 41
• Main Authors: Di Trani, Claudia Augusta, Fernandez-Sendin, Myriam, Cirella, Assunta, Segués, Aina, Olivera, Irene, Bolaños, Elixabet, Melero, Ignacio, Berraondo, Pedro
• Format: Journal Article
• Language: English
• Published: England 02.01.2022
• Subjects: COVID-19; COVID-19 Vaccines; Drug Discovery; Humans; Immunotherapy; Neoplasms - drug therapy; Neoplasms - genetics; RNA, Messenger - genetics; SARS-CoV-2; lipid nanoparticles; chimeric antigen receptor; mRNA; Cytokines; bispecific antibodies; adoptive T-cell transfer

Immune checkpoint inhibitors and adoptive T-cell therapy based on chimeric antigen receptors are the spearhead strategies to exploit the immune system to fight cancer. To take advantage of the full potential of the immune system, cancer immunotherapy must incorporate new biotechnologies such as mRNA...