Microangiopathy in human diabetic neuropathy: relationship between capillary abnormalities and the severity of neuropathy

• Published in: Diabetologia Vol. 32; no. 2; p. 92
• Main Authors: Malik, R A, Newrick, P G, Sharma, A K, Jennings, A, Ah-See, A K, Mayhew, T M, Jakubowski, J, Boulton, A J, Ward, J D
• Format: Journal Article
• Language: English
• Published: Germany 01.02.1989
• Subjects: Adult; Aged; Capillaries - pathology; Capillaries - ultrastructure; Diabetic Angiopathies - pathology; Diabetic Angiopathies - physiopathology; Diabetic Neuropathies - pathology; Diabetic Neuropathies - physiopathology; Female; Humans; Male; Microscopy, Electron; Middle Aged; Motor Neurons - physiology; Muscles - blood supply; Muscles - pathology; Muscles - ultrastructure; Neural Conduction; Neurologic Examination; Peripheral Nerves - physiopathology; Reference Values; Skin - blood supply; Skin - pathology; Skin - ultrastructure; Spinal Nerves - blood supply; Sural Nerve - blood supply

Clinical, electrophysiological and ultrastructural morphometric observations were made in 5 diabetic non-neuropathic patients, 5 diabetic patients with mild neuropathy and 11 diabetic patients with severe neuropathy. Capillary abnormalities were assessed in simultaneous nerve, muscle and skin biopsi...