Drug efflux transporters in the CNS

• Published in: Advanced drug delivery reviews Vol. 55; no. 1; pp. 83 - 105
• Main Authors: Sun, Haiying, Dai, Haiqing, Shaik, Naveed, Elmquist, William F
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 21.01.2003
• Subjects: Animals; ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Biological Transport, Active; Blood-Brain Barrier - physiology; Blood–brain barrier; Blood–CSF barrier; Central nervous system; Central Nervous System - metabolism; Clinical Trials as Topic; Drug Resistance, Multiple; Efflux transport proteins; Humans; Organic anion transporters; Organic Anion Transporters - metabolism; p-Glycoprotein; Substrate Specificity; Efflux transport proteins; Organic anion transporters; Blood–CSF barrier; p-Glycoprotein; Central nervous system; Blood–brain barrier

The central nervous system (CNS) contains important cellular barriers that maintain homeostasis by protecting the brain from circulating toxins and through the elimination of toxic metabolites generated in the brain. The barriers that limit the concentration of toxins and xenobiotics in the intersti...