The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

• Published in: Cell metabolism Vol. 33; no. 4; pp. 758 - 780
• Main Authors: Sylow, Lykke, Tokarz, Victoria L., Richter, Erik A., Klip, Amira
• Format: Journal Article
• Language: English
• Published: United States 06.04.2021
• Subjects: Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Exercise; Glucose - metabolism; Glucose Transporter Type 4 - metabolism; Humans; Insulin - metabolism; Muscle, Skeletal - metabolism; Oxidative Stress; Receptor, Insulin - metabolism; Signal Transduction; exercise-induced sensitization to insulin; insulin signaling; glucose uptake; insulin; glycogen; GLUT4; skeletal muscle; diabetes; insulin resistance

As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle contraction or exercise with increased sensitivity to subsequent insulin stimulation. Insulin's dominating contro...