The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice

• Published in: The Journal of experimental medicine Vol. 189; no. 2; pp. 347 - 358
• Main Authors: Jun, H S, Yoon, C S, Zbytnuik, L, van Rooijen, N, Yoon, J W
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 18.01.1999
• Subjects: Animals; Autoimmunity - immunology; Cell Differentiation - immunology; Clodronic Acid - pharmacology; Cytotoxicity, Immunologic - immunology; Diabetes Mellitus - genetics; Diabetes Mellitus - immunology; Fas Ligand Protein; Female; Interleukin-12 - pharmacology; Islets of Langerhans - drug effects; Islets of Langerhans - immunology; Macrophages - immunology; Membrane Glycoproteins - metabolism; Mice; Mice, Inbred NOD; Pancreas - drug effects; Pancreas - pathology; Perforin; Pore Forming Cytotoxic Proteins; Spleen - immunology; T-Lymphocytes - immunology; Tissue Transplantation

We have shown previously that the inactivation of macrophages in nonobese diabetic (NOD) mice results in the prevention of diabetes; however, the mechanisms involved remain unknown. In this study, we found that T cells in a macrophage-depleted environment lost their ability to differentiate into bet...