Effects of exercise on AKT/PGC1-α/FOXO3a pathway and muscle atrophy in cisplatin-administered rat skeletal muscle

• Published in: The Korean journal of physiology & pharmacology Vol. 25; no. 6; pp. 585 - 592
• Main Authors: Bae, Jun Hyun, Seo, Dae Yun, Lee, Sang Ho, Shin, Chaeyoung, Jamrasi, Parivash, Han, Jin, Song, Wook
• Format: Journal Article
• Language: English
• Published: The Korean Physiological Society and The Korean Society of Pharmacology 01.11.2021; 대한약리학회
• Subjects: Original; 약리학

Cisplatin has been reported to cause side effects such as muscle wasting in humans and rodents. The physiological mechanisms involved in preventing muscle wasting, such as the regulation of AKT, PGC1-α, and autophagy-related factor FOXO3a by MuRF 1 and Atrogin-1, remain unclear following different t...