Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology

• Published in: The Journal of experimental medicine Vol. 205; no. 4; pp. 841 - 852
• Main Authors: Gosert, Rainer, Rinaldo, Christine H, Funk, Georg A, Egli, Adrian, Ramos, Emilio, Drachenberg, Cinthia B, Hirsch, Hans H
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 14.04.2008
• Subjects: Adolescent; Adult; Aged; Animals; BK Virus - genetics; BK Virus - physiology; Cell Line; Cytopathogenic Effect, Viral; Disease Progression; DNA, Viral - blood; DNA, Viral - genetics; DNA, Viral - urine; Female; Gene Expression Regulation; Genes, Reporter; Humans; Kidney Transplantation; Male; Middle Aged; Polyomavirus; Polyomavirus Infections - pathology; Polyomavirus Infections - virology; Regulatory Sequences, Nucleic Acid - genetics; Tumor Virus Infections - pathology; Tumor Virus Infections - virology; Viral Fusion Proteins - metabolism; Viral Load; Viremia; Virus Replication

Immunosuppression is required for BK viremia and polyomavirus BK-associated nephropathy (PVAN) in kidney transplants (KTs), but the role of viral determinants is unclear. We examined BKV noncoding control regions (NCCR), which coordinate viral gene expression and replication. In 286 day-matched plas...