Functional MICA Variants Are Differentially Associated with Immune-Mediated Inflammatory Diseases

• Published in: International journal of molecular sciences Vol. 25; no. 5; p. 3036
• Main Authors: Wang, Chin-Man, Tan, Keng-Poo, Wu, Yeong-Jian Jan, Zheng, Jian-Wen, Wu, Jianming, Chen, Ji-Yih
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.03.2024; MDPI
• Subjects: Arthritis, Rheumatoid; Autoimmune diseases; Cells; Cytotoxicity; East Asian People; Genetic Predisposition to Disease; Histocompatibility Antigens Class I - genetics; Humans; Ligands; Lupus Erythematosus, Systemic - genetics; Lymphocytes; NK Cell Lectin-Like Receptor Subfamily K - genetics; Polymorphism; Polymorphism, Genetic; Proteins; Psoriasis; Risk factors; NKG2D; systemic lupus erythematosus; MICA alleles; rheumatoid arthritis; psoriasis

As the principal ligand for NKG2D, MICA elicits the recruitment of subsets of T cells and NK cells in innate immunity. MICA gene variants greatly impact the functionality and expression of MICA in humans. The current study evaluated whether MICA polymorphisms distinctively influence the pathogenesis...