Altered responses to potassium in cerebellar neurons from weaver heterozygote mice

• Published in: Experimental brain research Vol. 123; no. 3; pp. 298 - 306
• Main Authors: FOX, A. P, DLOUHY, S, GHETTI, B, HURLEY, J. H, NUCIFORA, P. G. P, NELSON, D. J, WON, L, HELLER, A
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.12.1998
• Subjects: Amino acids; Animals; Biological and medical sciences; Calcium - metabolism; Cell death; Cerebellum - cytology; Cerebellum - drug effects; Cerebellum - metabolism; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genetic aspects; Glutamate; Glutamic Acid - pharmacology; Heterozygote; Medical sciences; Mice; Mice, Neurologic Mutants; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Neurons; Neurons - drug effects; Neurons - metabolism; Potassium - pharmacology; Potassium Channels - drug effects; Potassium Channels, Inwardly Rectifying; Cerebellum; Nervous system diseases; Calcium; Granule neuron; Rodentia; Ionic channel; Ionic current; Cerebral disorder; Vertebrata; Mammalia; Cerebellar disease; Mouse; Cell death; Animal; Central nervous system disease; Ataxia; Intracellular; Mutation; Neurological disorder; Potassium

The pleiotropic weaver disease is caused by the mutation of a single amino acid in the G-protein-linked inwardly rectifying K+ channel, GIRK2. In homozygous (wv/wv) animals, the disease is characterized by loss of cerebellar and dopaminergic mesencephalic neurons as well as testicular cells, which p...