Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart

• Published in: Cardiovascular research Vol. 119; no. 1; pp. 136 - 154
• Main Authors: Li, Ziwen, Solomonidis, Emmanouil G, Berkeley, Bronwyn, Tang, Michelle Nga Huen, Stewart, Katherine Ross, Perez-Vicencio, Daniel, McCracken, Ian R, Spiroski, Ana-Mishel, Gray, Gillian A, Barton, Anna K, Sellers, Stephanie L, Riley, Paul R, Baker, Andrew H, Brittan, Mairi
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 17.03.2023
• Subjects: Adult; Animals; Endothelial Cells - metabolism; Endothelium - metabolism; Heart - physiology; Humans; Mice; Myocardial Infarction - genetics; Myocardial Infarction - metabolism; Myocytes, Cardiac - metabolism; Neovascularization, Pathologic - metabolism; Original; Regeneration; Vascular Endothelial Growth Factor C - metabolism; scRNA-seq meta-analysis; vascular regeneration; ischaemic heart disease

Abstract Aim Myocardial infarction remains the leading cause of heart failure. The adult human heart lacks the capacity to undergo endogenous regeneration. New blood vessel growth is integral to regenerative medicine necessitating a comprehensive understanding of the pathways that regulate vascular...