Elevated Pentraxin-3 Concentrations in Patients With Leprosy Potential Biomarker of Erythema Nodosum Leprosum

• Published in: The Journal of infectious diseases Vol. 216; no. 12; pp. 1635 - 1643
• Main Authors: Mendes, Mayara Abud, de Carvalho, Daniel Serra, Amadeu, Thaís Porto, de Andrade Silva, Bruno Jorge, da Silva Prata, Rhana Berto, da Silva, Camila Oliveira, Ferreira, Helen, de Andrea Hacker, Mariana, Nery, José Augusto Costa, Pinheiro, Roberta Olmo, Sampaio, Elizabeth Pereira, Sarno, Euzenir Nunes, Schmitz, Veronica
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 19.12.2017
• Subjects: Adolescent; Adult; Aged; BACTERIAL PATHOGENESIS AND HOST RESPONSE; Biomarkers - analysis; C-Reactive Protein - analysis; C-Reactive Protein - genetics; Case-Control Studies; Child; Enzyme-Linked Immunosorbent Assay; Erythema Nodosum - diagnosis; Erythema Nodosum - pathology; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Leprostatic Agents - administration & dosage; Leprosy, Lepromatous - diagnosis; Leprosy, Lepromatous - pathology; Male; Middle Aged; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Serum Amyloid P-Component - analysis; Serum Amyloid P-Component - genetics; Skin - pathology; Thalidomide - administration & dosage; Young Adult; leprosy; ENL; PTX3; biomarker

High pentraxin-3 serum levels are presented in multibacillary leprosy patients with or without erythema nodosum leprosum (ENL) and distinguish them from healthy subjects and patients with reversal reactions. The article provides a new molecular target in ENL pathogenesis. Abstract Background Leprosy...