BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes

• Published in: Nucleic acids research Vol. 51; no. 20; pp. 11080 - 11103
• Main Authors: Burdett, Hayden, Foglizzo, Martina, Musgrove, Laura J, Kumar, Dhananjay, Clifford, Gillian, Campbell, Lisa J, Heath, George R, Zeqiraj, Elton, Wilson, Marcus D
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 10.11.2023
• Subjects: BRCA1 Protein - chemistry; BRCA1 Protein - metabolism; Chromatin - chemistry; Chromatin - metabolism; Genome Integrity, Repair and; HeLa Cells; Histones - metabolism; Humans; Nucleosomes; Tumor Suppressor Proteins - genetics; Ubiquitin-Protein Ligases - chemistry; Ubiquitin-Protein Ligases - metabolism

Abstract Chromatin association of the BRCA1–BARD1 heterodimer is critical to promote homologous recombination repair of DNA double-strand breaks (DSBs) in S/G2. How the BRCA1–BARD1 complex interacts with chromatin that contains both damage induced histone H2A ubiquitin and inhibitory H4K20 methylati...