Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae

• Published in: Clinical infectious diseases Vol. 76; no. 3; pp. e487 - e490
• Main Authors: Swank, Zoe, Senussi, Yasmeen, Manickas-Hill, Zachary, Yu, Xu G, Li, Jonathan Z, Alter, Galit, Walt, David R
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 08.02.2023
• Subjects: Antigens, Viral - blood; Antigens, Viral - immunology; Biomarkers - blood; Brief Report; COVID-19 - blood; COVID-19 - complications; COVID-19 - immunology; Disease Progression; Editor's Choice; Humans; Post-Acute COVID-19 Syndrome - blood; Post-Acute COVID-19 Syndrome - diagnosis; Post-Acute COVID-19 Syndrome - immunology; SARS-CoV-2; Spike Glycoprotein, Coronavirus - blood; COVID-19; long COVID; SARS-CoV-2 antigens; post-acute sequelae of COVID-19 (PASC); spike

Abstract The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We...