Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae
Abstract The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We...
Saved in:
| Published in | Clinical infectious diseases Vol. 76; no. 3; pp. e487 - e490 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
US
Oxford University Press
08.02.2023
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Abstract
The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis. |
|---|---|
| AbstractList | Abstract
The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis. The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis.The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis. The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis. |
| Author | Walt, David R Swank, Zoe Alter, Galit Li, Jonathan Z Yu, Xu G Manickas-Hill, Zachary Senussi, Yasmeen |
| Author_xml | – sequence: 1 givenname: Zoe surname: Swank fullname: Swank, Zoe – sequence: 2 givenname: Yasmeen surname: Senussi fullname: Senussi, Yasmeen – sequence: 3 givenname: Zachary surname: Manickas-Hill fullname: Manickas-Hill, Zachary – sequence: 4 givenname: Xu G surname: Yu fullname: Yu, Xu G – sequence: 5 givenname: Jonathan Z surname: Li fullname: Li, Jonathan Z – sequence: 6 givenname: Galit surname: Alter fullname: Alter, Galit – sequence: 7 givenname: David R orcidid: 0000-0002-5524-7348 surname: Walt fullname: Walt, David R email: dwalt@bwh.harvard.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36052466$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kV1rFDEYhYNU7IdeeS-5EkHG5p18zMyVLNuqhYLFVbwMmcw7bXR2MiaZhf0P_mjT7lqqoBchIXnec044x-Rg9CMS8hzYG2ANP7Wuy8vYqiwfkSOQvCqUbOAgn5msC1Hz-pAcx_iNMYCaySfkkCsmS6HUEfl5hSG6mHBMdOmCnQeT3HhNV7jBgHRh54T0E8bJBZN82NLVduyCXyNd-uBHs3FhjrSkq8l9R3oR6SJGn9Mk7OhXl27olY-pMHcyDyfOXEQTkZYMmmz2Y8bB4FPyuDdDxGf7_YR8eXf-efmhuPz4_mK5uCysAJ6KlvOqKduWs65RLQPBoeKqFpZzI6oWQTYNSCbbXtracC6MkKoHbtoee5lvTsjbne40t2vsbP58MIOeglubsNXeOP3ny-hu9LXfaGCgGgEqK7zaKwSfs8ek1y5aHAYzop-jLivWVFxCXWb0xUOze5ffHWTg9Q6wwccYsL9HgOnbhnVuWO8bzjT8RVuXcmf-Nqkb_jHzcjfj5-m_4r8A9QO56w |
| CitedBy_id | crossref_primary_10_1001_jamainternmed_2024_2007 crossref_primary_10_1038_s41586_023_06651_y crossref_primary_10_1016_j_jtcme_2024_11_009 crossref_primary_10_1097_EBP_0000000000001943 crossref_primary_10_1007_s11357_024_01227_8 crossref_primary_10_1016_j_ymthe_2025_01_007 crossref_primary_10_1111_nyas_15132 crossref_primary_10_3389_fimmu_2023_1174184 crossref_primary_10_1097_WCO_0000000000001154 crossref_primary_10_3389_fimmu_2024_1345499 crossref_primary_10_1007_s10238_023_01065_6 crossref_primary_10_3389_fimmu_2023_1135815 crossref_primary_10_3389_fnins_2023_1232480 crossref_primary_10_3390_ijms242317039 crossref_primary_10_1134_S2079086423600480 crossref_primary_10_1016_j_endmts_2024_100163 crossref_primary_10_1126_scitranslmed_ado2101 crossref_primary_10_3390_s23062887 crossref_primary_10_1038_s41590_024_01778_0 crossref_primary_10_1093_ofid_ofaf048 crossref_primary_10_1007_s15010_024_02386_8 crossref_primary_10_1126_scitranslmed_ado2106 crossref_primary_10_1007_s11606_024_09254_z crossref_primary_10_1016_j_bbi_2024_04_015 crossref_primary_10_1016_j_cmi_2024_03_027 crossref_primary_10_1016_j_jiph_2024_02_018 crossref_primary_10_3390_v16081266 crossref_primary_10_1016_S1473_3099_24_00211_1 crossref_primary_10_15252_emmm_202216351 crossref_primary_10_3390_ijms252413360 crossref_primary_10_1016_j_thromres_2024_109195 crossref_primary_10_1016_j_ajem_2023_09_051 crossref_primary_10_3389_fmicb_2023_1196721 crossref_primary_10_3390_jcm14051590 crossref_primary_10_3389_fmed_2023_1191354 crossref_primary_10_1016_j_anai_2023_10_032 crossref_primary_10_7717_peerj_16669 crossref_primary_10_3390_microorganisms11041015 crossref_primary_10_7759_cureus_57008 crossref_primary_10_1055_s_0043_1776713 crossref_primary_10_1016_j_immuni_2024_05_010 crossref_primary_10_1021_acs_jmedchem_4c00735 crossref_primary_10_3390_vaccines12080887 crossref_primary_10_3389_fncel_2024_1481963 crossref_primary_10_1186_s12967_023_04552_2 crossref_primary_10_1002_mef2_80 crossref_primary_10_1039_D3AY01585H crossref_primary_10_2196_47079 crossref_primary_10_1007_s13577_022_00809_y crossref_primary_10_1007_s15010_024_02293_y crossref_primary_10_1016_j_idc_2025_02_007 crossref_primary_10_1038_s41586_024_07029_4 crossref_primary_10_1186_s12964_023_01397_6 crossref_primary_10_1021_acschemneuro_2c00610 crossref_primary_10_3390_covid5010006 crossref_primary_10_3390_microorganisms11122959 crossref_primary_10_1515_mr_2024_0013 crossref_primary_10_1002_jcb_30415 crossref_primary_10_1097_PSY_0000000000001280 crossref_primary_10_3390_ijerph20227058 crossref_primary_10_1093_infdis_jiad395 crossref_primary_10_61373_bm024p_0064 crossref_primary_10_1016_j_anai_2024_08_021 crossref_primary_10_1097_COH_0000000000000789 crossref_primary_10_17816_CI636474 crossref_primary_10_1007_s00296_023_05319_0 crossref_primary_10_1016_j_jbc_2024_107831 crossref_primary_10_1093_cid_ciac895 crossref_primary_10_3390_v16071089 crossref_primary_10_1016_j_lanepe_2023_100724 crossref_primary_10_3390_ijms25169050 crossref_primary_10_1093_ofid_ofae561 crossref_primary_10_1126_scitranslmed_adk3295 crossref_primary_10_1016_j_fmc_2023_06_001 crossref_primary_10_1038_s41586_024_07873_4 crossref_primary_10_3389_fped_2024_1340385 crossref_primary_10_3390_ijms241914868 crossref_primary_10_3389_fimmu_2023_1158460 crossref_primary_10_1016_j_pccm_2023_10_003 crossref_primary_10_1038_s41541_024_00815_1 crossref_primary_10_1002_jmv_29757 crossref_primary_10_1071_MA24005 crossref_primary_10_3389_fimmu_2023_1107156 crossref_primary_10_1111_papr_13350 crossref_primary_10_1177_15910199241273946 crossref_primary_10_1016_j_celrep_2023_112189 crossref_primary_10_1186_s12967_023_04515_7 crossref_primary_10_1212_NXI_0000000000200227 crossref_primary_10_1097_RHU_0000000000002054 crossref_primary_10_3390_biom14030245 crossref_primary_10_5692_clinicalneurol_cn_001902 crossref_primary_10_1016_j_ijid_2023_11_038 crossref_primary_10_1016_j_pnpbp_2025_111279 crossref_primary_10_1016_j_intimp_2024_112673 crossref_primary_10_1093_ofid_ofad466 crossref_primary_10_1016_j_bbi_2024_07_034 crossref_primary_10_1055_a_1927_4006 crossref_primary_10_1055_a_2335_0198 crossref_primary_10_3389_fendo_2024_1434331 crossref_primary_10_1038_s41467_024_51893_7 crossref_primary_10_1002_jmv_29887 crossref_primary_10_1177_20420986241226566 crossref_primary_10_4103_hm_HM_D_23_00043 crossref_primary_10_1126_scitranslmed_adf6598 crossref_primary_10_1016_j_banm_2024_01_002 crossref_primary_10_1111_joim_20000 crossref_primary_10_1111_eci_14149 crossref_primary_10_5501_wjv_v12_i3_204 crossref_primary_10_1111_joim_13603 crossref_primary_10_3390_ijms26010364 crossref_primary_10_1016_j_vaccine_2024_126358 crossref_primary_10_1016_j_amjmed_2024_04_030 crossref_primary_10_1016_j_exphem_2023_11_002 crossref_primary_10_3389_fimmu_2023_1303971 crossref_primary_10_3389_fmolb_2023_1157651 crossref_primary_10_1038_s41598_024_66473_4 crossref_primary_10_1016_j_jtauto_2025_100280 crossref_primary_10_3390_biomedicines12040913 crossref_primary_10_1016_j_psyneuen_2024_107269 crossref_primary_10_14336_AD_2024_0405 crossref_primary_10_1126_sciimmunol_adm7908 crossref_primary_10_3389_fped_2024_1484941 crossref_primary_10_1515_tnsci_2022_0352 crossref_primary_10_3390_ijms24129873 crossref_primary_10_1124_jpet_124_002154 crossref_primary_10_1093_ofid_ofad686 crossref_primary_10_1097_JOM_0000000000002961 crossref_primary_10_3390_microorganisms11030713 crossref_primary_10_1038_s43856_024_00668_8 crossref_primary_10_3390_v16030342 crossref_primary_10_3389_fmed_2023_1138644 crossref_primary_10_3390_v15071545 crossref_primary_10_14412_1996_7012_2023_6_7_13 crossref_primary_10_7189_jogh_13_06020 crossref_primary_10_1016_j_ijid_2023_09_006 crossref_primary_10_3389_fcimb_2024_1477585 crossref_primary_10_1016_j_jaci_2024_12_1074 crossref_primary_10_1016_j_autrev_2023_103452 crossref_primary_10_1016_j_tim_2023_06_004 crossref_primary_10_1161_CIRCRESAHA_122_321930 crossref_primary_10_1002_mef2_70004 crossref_primary_10_1016_j_amjmed_2023_04_010 crossref_primary_10_1016_j_ypmed_2024_108004 crossref_primary_10_1038_s41579_022_00846_2 crossref_primary_10_1016_j_ccm_2024_02_019 crossref_primary_10_3389_fimmu_2024_1448659 crossref_primary_10_1002_jmv_29676 crossref_primary_10_1007_s11357_024_01487_4 crossref_primary_10_7554_eLife_86015 crossref_primary_10_3390_diagnostics13213368 crossref_primary_10_1016_j_autrev_2024_103606 crossref_primary_10_1016_j_cell_2024_07_054 crossref_primary_10_1038_s41380_023_02084_1 crossref_primary_10_1111_jce_16117 crossref_primary_10_3390_medicina60081325 crossref_primary_10_1016_j_vaccine_2025_126744 crossref_primary_10_1186_s42234_025_00167_8 crossref_primary_10_3389_fimmu_2024_1329162 crossref_primary_10_3390_ijms24108579 crossref_primary_10_1016_j_chom_2024_11_007 crossref_primary_10_1109_TCBB_2024_3378470 crossref_primary_10_1016_j_bbi_2023_12_017 crossref_primary_10_1016_j_lanwpc_2024_101218 crossref_primary_10_3390_bios13070739 crossref_primary_10_1016_j_intimp_2024_111930 crossref_primary_10_1038_s41538_024_00261_2 crossref_primary_10_1093_ofid_ofae462 crossref_primary_10_3390_ijerph21020242 crossref_primary_10_3389_fimmu_2023_1147549 crossref_primary_10_1016_j_eclinm_2023_102146 crossref_primary_10_1097_ID9_0000000000000158 crossref_primary_10_3390_ijms241612962 crossref_primary_10_1016_S1473_3099_24_00171_3 crossref_primary_10_3390_jcm13175013 crossref_primary_10_1016_j_slasd_2024_100179 crossref_primary_10_1016_j_isci_2023_106935 crossref_primary_10_1053_j_gastro_2024_04_008 crossref_primary_10_1002_jmv_28364 crossref_primary_10_1002_jmv_29333 crossref_primary_10_1126_scitranslmed_adr1032 crossref_primary_10_1002_jmv_29216 crossref_primary_10_1055_s_0043_1767716 crossref_primary_10_3390_biomedicines12030581 crossref_primary_10_1016_j_mito_2024_101849 crossref_primary_10_3390_v15030783 crossref_primary_10_1371_journal_pmed_1004511 crossref_primary_10_3390_ijms25021330 crossref_primary_10_1055_s_0042_1759568 crossref_primary_10_1093_cid_ciae205 crossref_primary_10_1016_j_cmi_2024_09_001 crossref_primary_10_1186_s13741_023_00305_3 crossref_primary_10_1016_j_rmed_2024_107763 crossref_primary_10_1016_j_isci_2024_110387 crossref_primary_10_1007_s11033_023_08844_0 crossref_primary_10_1152_ajplung_00410_2022 crossref_primary_10_1002_iid3_70137 crossref_primary_10_1016_j_mayocp_2023_04_007 crossref_primary_10_3390_v17010098 crossref_primary_10_1016_j_jinf_2024_106358 crossref_primary_10_3389_fphys_2023_1203472 crossref_primary_10_4049_jimmunol_2300804 crossref_primary_10_1016_S1473_3099_24_00769_2 crossref_primary_10_1038_s41390_024_03777_1 crossref_primary_10_26442_00403660_2024_03_202647 crossref_primary_10_1016_j_jacadv_2024_100961 crossref_primary_10_1007_s11886_024_02087_6 crossref_primary_10_36425_rehab121733 crossref_primary_10_1515_nipt_2023_0024 crossref_primary_10_1016_j_pmr_2023_04_007 crossref_primary_10_1002_ana_26649 crossref_primary_10_1007_s10753_024_02208_x crossref_primary_10_1007_s11357_023_01058_z crossref_primary_10_7554_eLife_86764_3 crossref_primary_10_3390_ijms24065312 crossref_primary_10_1016_j_expneurol_2024_115020 crossref_primary_10_1016_j_compbiomed_2024_108507 crossref_primary_10_5694_mja2_52456 crossref_primary_10_3390_ijms242417198 crossref_primary_10_1002_mco2_426 crossref_primary_10_1016_j_jtha_2023_04_039 crossref_primary_10_3389_fimmu_2023_1117464 crossref_primary_10_1038_s41564_024_01802_x crossref_primary_10_5937_mp74_47797 crossref_primary_10_1016_j_amjmed_2024_07_030 crossref_primary_10_1080_13543784_2023_2230121 crossref_primary_10_3389_fimmu_2023_1234307 crossref_primary_10_1016_j_yexcr_2023_113853 crossref_primary_10_1038_s41598_024_63071_2 crossref_primary_10_3390_microorganisms13010126 crossref_primary_10_1515_cclm_2024_0036 crossref_primary_10_1002_jcb_30514 crossref_primary_10_1111_tid_14281 crossref_primary_10_1007_s10456_023_09890_9 crossref_primary_10_1016_j_lanmic_2024_100967 crossref_primary_10_1038_s41467_023_40012_7 crossref_primary_10_1038_s41577_023_00904_7 crossref_primary_10_1038_s41390_023_02627_w crossref_primary_10_1016_j_prrv_2024_01_002 crossref_primary_10_1016_j_eclinm_2024_102500 crossref_primary_10_1038_s41392_023_01640_z crossref_primary_10_46308_kmj_2023_00269 crossref_primary_10_17816_medjrf133829 crossref_primary_10_3346_jkms_2024_39_e237 crossref_primary_10_1016_j_crneur_2023_100112 crossref_primary_10_1111_pai_14060 crossref_primary_10_3390_v16040647 crossref_primary_10_3389_fmed_2023_1187163 crossref_primary_10_1002_jmv_70107 crossref_primary_10_31857_S0042132424020046 crossref_primary_10_3390_ijms241310458 crossref_primary_10_3390_s25061637 crossref_primary_10_3390_v15030754 crossref_primary_10_3389_fnut_2023_1278039 crossref_primary_10_1371_journal_pone_0286297 crossref_primary_10_3389_fimmu_2024_1502937 crossref_primary_10_1016_S2213_2600_23_00142_X crossref_primary_10_1177_21501319241254751 crossref_primary_10_1007_s12020_023_03518_0 crossref_primary_10_7554_eLife_86764 crossref_primary_10_1016_j_jtha_2023_07_012 crossref_primary_10_1038_s41467_023_44432_3 crossref_primary_10_17816_MAJ624867 crossref_primary_10_1016_j_virol_2024_110366 crossref_primary_10_1186_s12967_024_05117_7 crossref_primary_10_3390_life14020279 |
| Cites_doi | 10.1073/pnas.2010722117 10.1007/s11481-021-10029-0 10.1016/j.mayocp.2021.11.033 10.1038/s41591-021-01283-z 10.1172/JCI149633 10.1002/jev2.12112 10.1093/clinchem/hvaa213 10.1042/CS20210735 10.1161/CIRCRESAHA.121.318902 10.1093/infdis/jiab490 10.1038/s41590-021-01113-x 10.21203/rs.3.rs-1139035/v1 10.1016/j.it.2022.02.008 10.1093/cid/ciab465 10.1016/j.medj.2022.04.001 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022 The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| Copyright_xml | – notice: The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022 – notice: The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1093/cid/ciac722 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1537-6591 |
| EndPage | e490 |
| ExternalDocumentID | PMC10169416 36052466 10_1093_cid_ciac722 10.1093/cid/ciac722 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIH – fundername: ; |
| GroupedDBID | --- ..I .2P .GJ .I3 .ZR 08P 0R~ 1KJ 1TH 29B 2AX 2WC 36B 3O- 4.4 48X 53G 5GY 5RE 5VS 5WD 6J9 70D AABZA AACGO AACZT AAJKP AAJQQ AAMVS AANCE AAOGV AAPGJ AAPNW AAPQZ AAPXW AAQQT AARHZ AAUAY AAUQX AAVAP AAWDT AAYOK ABBHK ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABLJU ABNGD ABNHQ ABNKS ABOCM ABPLY ABPQP ABPTD ABQLI ABQNK ABSMQ ABTLG ABVGC ABWST ABXSQ ABXVV ABZBJ ACFRR ACGFO ACGFS ACHIC ACPQN ACPRK ACUFI ACUKT ACUTJ ACUTO ACVCV ACYHN ACZBC ADBBV ADEYI ADGZP ADHKW ADHZD ADIPN ADMTO ADNBA ADOCK ADQBN ADQXQ ADRTK ADULT ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKPW AEKSI AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEUPB AEWNT AEXZC AFFNX AFFQV AFFZL AFIYH AFOFC AFRAH AFSHK AFXAL AFYAG AGINJ AGKEF AGKRT AGMDO AGQXC AGSYK AGUTN AHMBA AHMMS AHXPO AI. AIAGR AIJHB AJDVS AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APJGH APWMN AQDSO AQKUS AQVQM ASPBG ATGXG AVNTJ AVWKF AXUDD AZFZN BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM BZKNY C1A C45 CDBKE CS3 CZ4 DAKXR DCCCD DIK DILTD DU5 D~K E3Z EBS EE~ EIHJH EJD EMOBN ENERS F5P F9B FECEO FEDTE FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC H13 H5~ HAR HQ3 HTVGU HVGLF HW0 HZ~ IOX IPSME J21 J5H JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JST JXSIZ KAQDR KBUDW KOP KSI KSN L7B M49 MBLQV MHKGH MJL ML0 N4W N9A NGC NOMLY NOYVH NU- NVLIB O0~ O9- OAUYM OAWHX OBFPC OCZFY ODMLO ODZKP OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P2P P6G PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD RD5 ROX ROZ RUSNO RW1 RXO SA0 SJN TCURE TEORI TJX TMA TR2 VH1 W8F X7H Y6R YAYTL YKOAZ YXANX ZGI ~91 ~S- AAYXX AGORE AHGBF AJBYB CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c413t-b33792bb30d96b0143173684c33a47be15991505bf5c8a334a456f13abfef58a3 |
| ISSN | 1058-4838 1537-6591 |
| IngestDate | Thu Aug 21 18:36:20 EDT 2025 Thu Jul 10 18:20:02 EDT 2025 Thu Apr 03 07:01:17 EDT 2025 Thu Apr 24 22:52:34 EDT 2025 Tue Jul 01 01:18:50 EDT 2025 Wed Apr 02 07:04:37 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | COVID-19 long COVID SARS-CoV-2 antigens post-acute sequelae of COVID-19 (PASC) spike |
| Language | English |
| License | This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights) https://academic.oup.com/pages/standard-publication-reuse-rights The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c413t-b33792bb30d96b0143173684c33a47be15991505bf5c8a334a456f13abfef58a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Potential conflicts of interest. D. W. has a financial interest in Quanterix Corporation, a company that develops an ultra-sensitive digital immunoassay platform. He is an inventor of the single molecule array technology, a founder of the company and also serves on its Board of Directors. D. W.'s interests were reviewed and are managed by Brigham and Women's Hospital and Partners Healthcare in accordance with their conflict of interest policies. He also holds stock and stock options for Quanterix Corporation. G. A. reports grants or contracts from Biontech, Merck, and BMS; consulting fees from Sanofi and Moderna, payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from GSK and Astrazeneca; patents from REFORM—Antibody Engineering—MGH; CAPRISA CAP276 HIV monoclonal DSMB; is a part of the Sanofi Scientific Advisory Board; and holds stock or stock options for Systems Seromyx and Leyden Labs. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. |
| ORCID | 0000-0002-5524-7348 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/10169416 |
| PMID | 36052466 |
| PQID | 2709735182 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_10169416 proquest_miscellaneous_2709735182 pubmed_primary_36052466 crossref_primary_10_1093_cid_ciac722 crossref_citationtrail_10_1093_cid_ciac722 oup_primary_10_1093_cid_ciac722 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-02-08 |
| PublicationDateYYYYMMDD | 2023-02-08 |
| PublicationDate_xml | – month: 02 year: 2023 text: 2023-02-08 day: 08 |
| PublicationDecade | 2020 |
| PublicationPlace | US |
| PublicationPlace_xml | – name: US – name: United States |
| PublicationTitle | Clinical infectious diseases |
| PublicationTitleAlternate | Clin Infect Dis |
| PublicationYear | 2023 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| References | Ogata (2023053119095787000_ciac722-B5) 2020; 66 Peluso (2023053119095787000_ciac722-B15) 2021; 224 Ganesh (2023053119095787000_ciac722-B4) 2022; 97 Nalbandian (2023053119095787000_ciac722-B1) 2021; 27 Yonker (2023053119095787000_ciac722-B8) 2021; 131 Natarajan (2023053119095787000_ciac722-B9) 2022; 3 Ogata (2023053119095787000_ciac722-B6) 2022 Avolio (2023053119095787000_ciac722-B12) 2021; 135 Peluso (2023053119095787000_ciac722-B3) 2022; 43 Lei (2023053119095787000_ciac722-B13) 2021; 128 DeOre (2023053119095787000_ciac722-B14) 2021; 16 Chertow (2023053119095787000_ciac722-B7) 2021 Cheng (2023053119095787000_ciac722-B11) 2020; 117 Troyer (2023053119095787000_ciac722-B10) 2021; 10 Phetsouphanh (2023053119095787000_ciac722-B16) 2022; 23 World Health Organization (WHO) (2023053119095787000_ciac722-B2) 36214989 - Hum Cell. 2023 Jan;36(1):483-485 |
| References_xml | – volume: 117 start-page: 25254 year: 2020 ident: 2023053119095787000_ciac722-B11 article-title: Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation publication-title: Proc Natl Acad Sci doi: 10.1073/pnas.2010722117 – volume: 16 start-page: 722 year: 2021 ident: 2023053119095787000_ciac722-B14 article-title: SARS-CoV-2 spike protein disrupts blood–brain barrier integrity via RhoA activation publication-title: J Neuroimmune Pharmacol doi: 10.1007/s11481-021-10029-0 – ident: 2023053119095787000_ciac722-B2 – volume: 97 start-page: 454 year: 2022 ident: 2023053119095787000_ciac722-B4 article-title: The female-predominant persistent immune dysregulation of the post-COVID syndrome publication-title: Mayo Clin Proc doi: 10.1016/j.mayocp.2021.11.033 – volume: 27 start-page: 601 year: 2021 ident: 2023053119095787000_ciac722-B1 article-title: Post-acute COVID-19 syndrome publication-title: Nat Med doi: 10.1038/s41591-021-01283-z – volume: 131 year: 2021 ident: 2023053119095787000_ciac722-B8 article-title: Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier publication-title: J Clin Invest doi: 10.1172/JCI149633 – volume: 10 start-page: e12112 year: 2021 ident: 2023053119095787000_ciac722-B10 article-title: Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies publication-title: J Extracell Vesicles doi: 10.1002/jev2.12112 – volume: 66 start-page: 1562 year: 2020 ident: 2023053119095787000_ciac722-B5 article-title: Ultra-sensitive serial profiling of SARS-CoV-2 antigens and antibodies in plasma to understand disease progression in COVID-19 patients with severe disease publication-title: Clin Chem doi: 10.1093/clinchem/hvaa213 – volume: 135 start-page: 2667 year: 2021 ident: 2023053119095787000_ciac722-B12 article-title: The SARS-CoV-2 spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease publication-title: Clin Sci doi: 10.1042/CS20210735 – volume: 128 start-page: 1323 year: 2021 ident: 2023053119095787000_ciac722-B13 article-title: SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE 2 publication-title: Circ Res doi: 10.1161/CIRCRESAHA.121.318902 – volume: 224 start-page: 1839 year: 2021 ident: 2023053119095787000_ciac722-B15 article-title: Markers of immune activation and inflammation in individuals with postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection publication-title: J Infect Dis doi: 10.1093/infdis/jiab490 – volume: 23 start-page: 210 year: 2022 ident: 2023053119095787000_ciac722-B16 article-title: Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection publication-title: Nat Immunol doi: 10.1038/s41590-021-01113-x – year: 2021 ident: 2023053119095787000_ciac722-B7 article-title: SARS-CoV-2 infection and persistence throughout the human body and brain doi: 10.21203/rs.3.rs-1139035/v1 – volume: 43 start-page: 268 year: 2022 ident: 2023053119095787000_ciac722-B3 article-title: Early clues regarding the pathogenesis of long-COVID publication-title: Trends Immunol doi: 10.1016/j.it.2022.02.008 – start-page: 715 year: 2022 ident: 2023053119095787000_ciac722-B6 article-title: Circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine antigen detected in the plasma of mRNA-1273 vaccine recipients publication-title: Clin Infect Dis doi: 10.1093/cid/ciab465 – volume: 3 start-page: 371 year: 2022 ident: 2023053119095787000_ciac722-B9 article-title: Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection publication-title: Med doi: 10.1016/j.medj.2022.04.001 – reference: 36214989 - Hum Cell. 2023 Jan;36(1):483-485 |
| SSID | ssj0011805 |
| Score | 2.7218285 |
| Snippet | Abstract
The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC... The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we... |
| SourceID | pubmedcentral proquest pubmed crossref oup |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e487 |
| SubjectTerms | Antigens, Viral - blood Antigens, Viral - immunology Biomarkers - blood Brief Report COVID-19 - blood COVID-19 - complications COVID-19 - immunology Disease Progression Editor's Choice Humans Post-Acute COVID-19 Syndrome - blood Post-Acute COVID-19 Syndrome - diagnosis Post-Acute COVID-19 Syndrome - immunology SARS-CoV-2 Spike Glycoprotein, Coronavirus - blood |
| Title | Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/36052466 https://www.proquest.com/docview/2709735182 https://pubmed.ncbi.nlm.nih.gov/PMC10169416 |
| Volume | 76 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKkBAviDvduBiJJ6KwNHZuj9MAtaDyQDdR9lLZriOqjWxqE5D4Dfwj_hzn2M5tVGjwErWu7So5X87F50bICyXzlEdc-DIIpQ_yNvOFClJQ5LCWeLpUSuOB_vRDPD7m7-bRfDD41Ylaqkr5Sv3YmlfyP1SFMaArZsn-A2WbTWEAPgN94QoUhuuVaIzh60imovQOV2tlOnFhgW0Nd6K9A4UxAB87vvSZK08AXGANGvi31braeKE3u1idam-yaWgFSugnPJ_FTr7wUHGb7orX1qnjgVTP4M9AspyJfsmDOt2yDvWCRc4T1Kjws--iMJz45LzB1kwXFbyjRiyIzVfdpqlNBWx4Kjb-2JXfPhGYL9b4Az5XODivXKswd4wRMhP53OW8QWRONu2Qrrlx4seRbedVs2vbLsbBknV4r-ZOdGv31fYh_UNG2PpZymACnqlKbGJ0vxb3JRnZRC5anz1bYMNjt_gauR6CjWLs-cn7xoU1Sk38bHNfLjkUFu_D4n23uKcO9VIsO5bO5YDdjgZ0dJvccqYLPbA4vEMGurhLbkxdcMY98rOFI-3AkVo4UgNH2oEjreFIO-CiITVwpJMNbeFIEY60hWNvhYMjRTjSGo73yfHbN0eHY981-_AV6FGlLxlLslBKFiyzWGLVyVHC4pQrxgRPpAa1OwPjJZJ5pFLBGBeg-ucjJmSu8whGHpCd4rzQjwhNgijIEy2TVGY8zYJsKfMR50spmGRZuhySl_UzBxraiBdsyHK22ELdIfCzevKFLQCzfdozIN7fZzyvCbsAFo5-OVFoeAEXYYI1syKw9IfkoSV0sxGLgyjkcTwkaQ8CzQQsD9__pVh9MWXi8VwuA3tr92p3sEdutu_lY7JTriv9BBTuUj41wP4NJYTfIA |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Persistent+Circulating+Severe+Acute+Respiratory+Syndrome+Coronavirus+2+Spike+Is+Associated+With+Post-acute+Coronavirus+Disease+2019+Sequelae&rft.jtitle=Clinical+infectious+diseases&rft.au=Swank%2C+Zoe&rft.au=Senussi%2C+Yasmeen&rft.au=Manickas-Hill%2C+Zachary&rft.au=Yu%2C+Xu+G&rft.date=2023-02-08&rft.issn=1058-4838&rft.eissn=1537-6591&rft.volume=76&rft.issue=3&rft.spage=e487&rft.epage=e490&rft_id=info:doi/10.1093%2Fcid%2Fciac722&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_cid_ciac722 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1058-4838&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1058-4838&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1058-4838&client=summon |