Identification of contact and respiratory sensitizers according to IL-4 receptor α expression and IL-2 production

• Published in: Toxicology and applied pharmacology Vol. 260; no. 2; pp. 95 - 104
• Main Authors: Goutet, Michèle, Pépin, Elsa, Langonné, Isabelle, Huguet, Nelly, Ban, Masarin
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 15.04.2012; Elsevier
• Subjects: 60 APPLIED LIFE SCIENCES; Allergens - classification; Allergens - immunology; ANHYDRIDES; Animals; ASTHMA; Biological and medical sciences; Chemical contact and respiratory sensitizers; Dinitrochlorobenzene - immunology; Female; Flow Cytometry; Hypersensitivity - immunology; IgE-positive B cells; IL-2; IL-4; IL-4Rα; Immunoglobulin E - blood; Immunoglobulin E - immunology; Interleukin-2 - biosynthesis; Interleukin-2 - immunology; Local Lymph Node Assay; Medical sciences; MICE; Mice, Inbred BALB C; MOLECULES; OCCUPATIONAL SAFETY; Phthalic Anhydrides - immunology; RECEPTORS; Receptors, Cell Surface - biosynthesis; Receptors, Cell Surface - immunology; SENSITIZERS; Statistics, Nonparametric; TOLUENE; Toxicology; IL-4; Flow cytometry; IL-2; IgE-positive B cells; Chemical contact and respiratory sensitizers; IL-4Rα; Chemical compound; IgE; Cytokine; Biosynthesis; Identification; B-Lymphocyte; Respiratory system; Interleukin 4; Interleukin 2; Chemosensitizing agent; Sensitizer; Biological receptor

Identification of allergenic chemicals is an important occupational safety issue. While several methods exist to identify contact sensitizers, there is currently no validated model to predict the potential of chemicals to act as respiratory sensitizers. Previously, we reported that cytometry analysi...