Defective Thymocyte Maturation by Transgenic Expression of a Truncated Form of the T Lymphocyte Adapter Molecule and Fyn Substrate, Sin

• Published in: The Journal of immunology (1950) Vol. 169; no. 12; pp. 6900 - 6909
• Main Authors: Donlin, Laura T, Roman, Christopher A, Adlam, Matthew, Regelmann, Adam G, Alexandropoulos, Konstantina
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.12.2002
• Subjects: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport - biosynthesis; Adaptor Proteins, Vesicular Transport - genetics; Animals; Apoptosis - genetics; Apoptosis - immunology; Carrier Proteins - biosynthesis; Carrier Proteins - genetics; Carrier Proteins - physiology; Cell Differentiation - genetics; Cell Differentiation - immunology; Cell Survival - genetics; Cell Survival - immunology; Female; Gene Expression Regulation - immunology; Growth Inhibitors - genetics; Growth Inhibitors - physiology; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases - antagonists & inhibitors; Mitogen-Activated Protein Kinases - metabolism; Phosphoproteins - biosynthesis; Phosphoproteins - genetics; Phosphorylation; Proto-Oncogene Proteins - biosynthesis; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - physiology; Proto-Oncogene Proteins c-fyn; Receptors, Antigen, T-Cell - metabolism; Sequence Deletion; src-Family Kinases - physiology; Substrate Specificity; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - pathology; Thymus Gland - immunology; Thymus Gland - metabolism; Thymus Gland - pathology; Transgenes - immunology

Adapter molecules that promote protein-protein interactions play a central role in T lymphocyte differentiation and activation. In this study, we examined the role of the T lymphocyte-expressed adapter protein and Src kinase substrate, Sin, on thymocyte function using transgenic mice expressing an a...