Oncogenes expand during evolution to withstand somatic amplification

• Published in: Annals of oncology Vol. 29; no. 11; pp. 2254 - 2260
• Main Authors: Wang, X., Li, X., Zhang, L., Wong, S.H., Wang, M.H.T., Tse, G., Dai, R.Z.W., Nakatsu, G., Coker, O.O., Chen, Z., Ko, H., Chan, J.Y.K., Liu, T., Cheng, C.H.K., Cheng, A.S.L., To, K.F., Plewczynski, D., Sung, J.J.Y., Yu, J., Gin, T., Chan, M.T.V., Wu, W.K.K.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2018; Oxford University Press
• Subjects: amplification; Animals; Computational Biology; copy number alterations; Datasets as Topic; Drosophila; evolution; Evolution, Molecular; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genome, Human - genetics; Genomics - methods; Humans; Mice; Neoplasms - genetics; oncogene; Oncogenes - genetics; amplification; evolution; oncogene; copy number alterations

Cancer-related genes are under intense evolutionary pressure. We conjectured that gene size is an important determinant of amplification propensity for oncogenes and thus cancer susceptibility and therefore could be subject to natural selection. Gene information, including size and genomic locations...