Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries

• Published in: Frontiers in immunology Vol. 15; p. 1397890
• Main Authors: Vitale, Antonio, Caggiano, Valeria, Tufan, Abdurrahman, Ragab, Gaafar, Batu, Ezgi Deniz, Portincasa, Piero, Aragona, Emma, Sota, Jurgen, Conti, Giovanni, De Paulis, Amato, Rigante, Donato, Olivieri, Alma Nunzia, Şahin, Ali, La Torre, Francesco, Lopalco, Giuseppe, Cattalini, Marco, Maggio, Maria Cristina, Insalaco, Antonella, Sfikakis, Petros P., Verrecchia, Elena, Yildirim, Derya, Kucuk, Hamit, Kardas, Riza Can, Laymouna, Ahmed Hatem, Ghanema, Mahmoud, Saad, Moustafa Ali, Sener, Seher, Ercan Emreol, Hulya, Ozen, Seza, Jaber, Nour, Khalil, Mohamad, Di Ciaula, Agostino, Gaggiano, Carla, Malizia, Giuseppe, Affronti, Andrea, Patroniti, Serena, Romeo, Meri, Sbalchiero, Jessica, Della Casa, Francesca, Mormile, Ilaria, Silvaroli, Sara, Gicchino, Maria Francesca, Çelik, Neşe Çabuk, Tarsia, Maria, Karamanakos, Anastasios, Hernández-Rodríguez, José, Parronchi, Paola, Opris-Belinski, Daniela, Barone, Patrizia, Recke, Andreas, Costi, Stefania, Sfriso, Paolo, Giardini, Henrique A. Mayrink, Gentileschi, Stefano, Wiesik-Szewczyk, Ewa, Vasi, Ibrahim, Loconte, Roberta, Jahnz-Różyk, Karina, Martín-Nares, Eduardo, Torres-Ruiz, Jiram, Cauli, Alberto, Conforti, Alessandro, Emmi, Giacomo, Li Gobbi, Francesca, Biasi, Giovanni Rosario, Terribili, Riccardo, Ruscitti, Piero, Del Giudice, Emanuela, Tharwat, Samar, Brucato, Antonio Luca, Ogunjimi, Benson, Hinojosa-Azaola, Andrea, Balistreri, Alberto, Fabiani, Claudia, Frediani, Bruno, Cantarini, Luca
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2024
• Subjects: Adult; autoinflammatory diseases; Behcet Syndrome - complications; Behcet Syndrome - epidemiology; Cohort Studies; Familial Mediterranean Fever - complications; Familial Mediterranean Fever - epidemiology; Female; Fibromyalgia - epidemiology; Fibromyalgia - etiology; FMF; Humans; Male; Middle Aged; neoplasm; Neoplasms - epidemiology; Neoplasms - etiology; rare diseases; Registries; Risk Factors; treatment; tumor; Young Adult; rare diseases; treatment; neoplasm; tumor; FMF; autoinflammatory diseases

Inflammation has been associated with an increased risk for cancer development, while innate immune system activation could counteract the risk for malignancies. Familial Mediterranean fever (FMF) is a severe systemic inflammatory condition and also represents the archetype of innate immunity deregu...