Growth Hormone Receptor Is a Target for Presenilin-dependent γ-Secretase Cleavage

• Published in: The Journal of biological chemistry Vol. 280; no. 19; pp. 19331 - 19342
• Main Authors: Cowan, Jon W., Wang, Xiangdong, Guan, Ran, He, Kai, Jiang, Jing, Baumann, Gerhard, Black, Roy A., Wolfe, Michael S., Frank, Stuart J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.05.2005
• Subjects: Acetylcysteine - analogs & derivatives; Acetylcysteine - chemistry; ADAM Proteins; ADAM17 Protein; Adenoviridae - genetics; Adenoviridae - metabolism; Adipocytes - metabolism; Animals; Cell Line; Cell Line, Tumor; Cell Nucleus - metabolism; Cysteine Proteinase Inhibitors - pharmacology; Cytoplasm - metabolism; Down-Regulation; Fibroblasts - metabolism; Growth Hormone - metabolism; Humans; Immunoblotting; Immunoprecipitation; Kinetics; Leupeptins - pharmacology; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Metalloendopeptidases - chemistry; Mice; Mice, Knockout; Microscopy, Confocal; Models, Biological; Plasmids - metabolism; Presenilin-1; Proteasome Endopeptidase Complex - metabolism; Proteasome Inhibitors; Protein Binding; Protein Structure, Tertiary; Receptors, Somatotropin - metabolism; Recombinant Proteins - metabolism; Signal Transduction; Time Factors

Growth hormone receptor (GHR) is a cytokine receptor superfamily member that binds growth hormone (GH) via its extracellular domain and signals via interaction of its cytoplasmic domain with JAK2 and other signaling molecules. GHR is a target for inducible metalloprotease-mediated cleavage in its pe...