Growth Hormone Receptor Is a Target for Presenilin-dependent γ-Secretase Cleavage - Cowan, Jon W.; Wang, Xiangdong; Guan, Ran; He, Kai; Jiang, Jing; Baumann, Gerhard; Black, Roy A.; Wolfe, Michael S.; Frank, Stuart J. (The Journal of biological chemistry, 2005)
Keywords: Acetylcysteine - analogs & derivatives; Acetylcysteine - chemistry; ADAM Proteins; ADAM17 Protein; Adenoviridae - genetics; Adenoviridae - metabolism; Adipocytes - metabolism; Animals; Cell Line; Cell Line, Tumor; Cell Nucleus - metabolism; Cysteine Proteinase Inhibitors - pharmacology; Cytoplasm - metabolism; Down-Regulation; Fibroblasts - metabolism; Growth Hormone - metabolism; Humans; Immunoblotting; Immunoprecipitation; Kinetics; Leupeptins - pharmacology; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Metalloendopeptidases - chemistry; Mice; Mice, Knockout; Microscopy, Confocal; Models, Biological; Plasmids - metabolism; Presenilin-1; Proteasome Endopeptidase Complex - metabolism; Proteasome Inhibitors; Protein Binding; Protein Structure, Tertiary; Receptors, Somatotropin - metabolism; Recombinant Proteins - metabolism; Signal Transduction; Time Factors