Investigation of biomarkers to predict outcomes in allogeneic hematopoietic stem cell transplantation

• Published in: Cytotherapy (Oxford, England) Vol. 26; no. 8; pp. 921 - 929
• Main Authors: Tachibana, Takayoshi, Miyazaki, Takuya, Matsumura, Ayako, Hagihara, Maki, Tanaka, Masatsugu, Koyama, Satoshi, Ogusa, Eriko, Aoki, Jun, Nakajima, Yuki, Takahashi, Hiroyuki, Suzuki, Taisei, Ishii, Yoshimi, Teshigawara, Haruka, Matsumoto, Kenji, Hatayama, Mayumi, Izumi, Akihiko, Ikuta, Katsuya, Yamamoto, Koji, Kanamori, Heiwa, Fujisawa, Shin, Nakajima, Hideaki
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.08.2024
• Subjects: Adolescent; Adult; Advanced Basic Science; Aged; allogeneic hematopoietic cell transplantation; biomarkers; Biomarkers - blood; C-Reactive Protein - metabolism; CRP to platelet ratio; Female; Hematologic Neoplasms - mortality; Hematologic Neoplasms - therapy; Hematopoietic Stem Cell Transplantation - methods; Humans; Male; Middle Aged; Other; Prognosis; Prospective Studies; Transplantation Conditioning - methods; Transplantation, Homologous - methods; Treatment Outcome; Young Adult; CRP to platelet ratio; prognosis; biomarkers; allogeneic hematopoietic cell transplantation

•Biomarkers to predict outcomes were assessed from the clinico-statistical approach.•A prospective multicenter observational study was performed.•Six promising biomarkers were successfully identified and validated.•C-reactive protein to platelet ratio was a novel biomarker to predict transplant outc...