Modulation of the Nucleoside Triphosphatase/RNA Helicase and 5′-RNA Triphosphatase Activities of Dengue Virus Type 2 Nonstructural Protein 3 (NS3) by Interaction with NS5, the RNA-dependent RNA Polymerase

• Published in: The Journal of biological chemistry Vol. 280; no. 29; pp. 27412 - 27419
• Main Authors: Yon, Changsuek, Teramoto, Tadahisa, Mueller, Niklaus, Phelan, Jessica, Ganesh, Vannakambadi K., Murthy, Krishna H.M., Padmanabhan, R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.07.2005
• Subjects: Acid Anhydride Hydrolases - metabolism; Binding Sites; Dengue Virus - enzymology; Dengue virus type 2; Flaviviridae; Kinetics; Multiprotein Complexes; Nucleoside-Triphosphatase - metabolism; RNA Helicases - metabolism; RNA-Dependent RNA Polymerase - metabolism; Serine Endopeptidases - metabolism; Viral Nonstructural Proteins - metabolism

Dengue virus type 2 (DEN2), a member of the Flaviviridae family, is a re-emerging human pathogen of global significance. DEN2 nonstructural protein 3 (NS3) has a serine protease domain (NS3-pro) and requires the hydrophilic domain of NS2B (NS2BH) for activation. NS3 is also an RNA-stimulated nucleos...