Enhanced Purkinje cell survival but compromised cerebellar function in targeted anti-apoptotic protein transgenic mice

• Published in: Molecular and cellular neuroscience Vol. 29; no. 2; pp. 202 - 221
• Main Authors: Goswami, Jaideep, Martin, Loren A., Goldowitz, Daniel, Beitz, Alvin J., Feddersen, Rod M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2005
• Subjects: Adenovirus; Adenovirus E1B Proteins - genetics; Animals; Apoptosis - genetics; Cell Count; Cell Proliferation; Cell Survival - genetics; Cerebellar Diseases - genetics; Cerebellar Diseases - metabolism; Cerebellar Diseases - physiopathology; Cerebellum - abnormalities; Cerebellum - metabolism; Cerebellum - physiopathology; Gene Expression Regulation, Developmental - genetics; Gene Targeting; Guanine Nucleotide Exchange Factors; Humans; Mice; Mice, Transgenic; Movement Disorders - genetics; Movement Disorders - metabolism; Movement Disorders - physiopathology; Neuropeptides - genetics; Promoter Regions, Genetic - genetics; Proto-Oncogene Proteins c-bcl-2 - genetics; Purkinje Cells - metabolism; Simian virus 40

Regulation of Purkinje cell (PC) number is critical for proper assembly and function of the cerebellum. Murine cerebellar neurogenesis yields supernumerary populations of cells that are subject to programmed cell death during development and aging. This study focuses on the control of mouse PC numbe...