Phytochemical characterization and bioactivity of Lycium europaeum: A focus on antioxidant, antinociceptive, hepatoprotective and nephroprotective effects

[Display omitted] In this study, the antioxidant, antinociceptive, hepatoprotective, nephroprotective properties and the bioactive composition of Lycium europaeum were investigated. Polyphenols and total tannin contents were measured by colorimetric methods The antioxidant activity in vitro was eval...

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Published inBiomedicine & pharmacotherapy Vol. 95; pp. 1441 - 1450
Main Authors Rjeibi, Ilhem, Feriani, Anouar, Ben Saad, Anouar, Ncib, Sana, Sdayria, Jazia, Saidi, Issam, Souid, Sami, Hfaiedh, Najla, Allagui, Mohamed Salah
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.11.2017
Subjects
Analgesics - pharmacology
Analgesis
Animals
Antioxidant
Antioxidants - pharmacology
Bioactive compounds
Carbon Tetrachloride
CCl4
Flavonoids - analysis
Kidney - drug effects
Kidney - pathology
Kidneys
Liver
Liver - drug effects
Liver - pathology
Lycium - chemistry
Lycium europaeum
Male
Malondialdehyde - metabolism
Methanol
Mice
Phenols - analysis
Phytochemicals - pharmacology
Plant Extracts - pharmacology
Protective Agents - pharmacology
Quercetin - pharmacology
Rats, Wistar
Tannins - analysis
Toxicity Tests, Acute
Kidneys
Analgesis
Bioactive compounds
Liver
CCl4
Lycium europaeum
Antioxidant
CCl
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Abstract [Display omitted] In this study, the antioxidant, antinociceptive, hepatoprotective, nephroprotective properties and the bioactive composition of Lycium europaeum were investigated. Polyphenols and total tannin contents were measured by colorimetric methods The antioxidant activity in vitro was evaluated using the reducing power, 2,2-diphenyl-1-picrylhydrazyl radical and phosphomolybdenum assays. The hepatotoxicity and nephrotoxicity effects were studied using carbon tetrachloride (CCl4)-induced liver and renal injuries in mice. The analgesic activity was explored using the hot-plate and acetic acid tests in mice. Results showed that the methanol fraction of L. europaeum (LEM) had the highest level of total phenolic, total tannin, and flavonoid. HPLC-DAD analysis revealed the presence of twelve compounds among them caffeic acid was the major compound (140.18μg/g of extract). This fraction also showed the best antioxidant activity in vitro in the three used assays. In vivo, in the mice studies, CCl4 administration induced hepatotoxicity and nephrotoxicity by a significant rise in the levels of serum liver biomarkers (gamma glutamyl transferase, lactate dehydrogenase, and aminotransferases) and serum renal biomarkers (urea, creatinine, and uric acid). Similarly, levels of lipid peroxidation (MDA) in both tissues were found increased by CCl4 intoxication. Pretreatment with LEM and quercetin significantly restored the majority of these biological parameters to normal levels, as well as an improvement of histopathological changes. In addition, LEM showed an interesting analgesic activity. LEM decreased significantly the number of writhing induced by acetic acid and prolonged the reaction time in response to thermal stimulus in mice. Therefore, it was speculated that the obtained results highlighted the potential use of L. europaeum as a source of bioactive compounds with pharmacological advantages
AbstractList In this study, the antioxidant, antinociceptive, hepatoprotective, nephroprotective properties and the bioactive composition of Lycium europaeum were investigated. Polyphenols and total tannin contents were measured by colorimetric methods The antioxidant activity in vitro was evaluated using the reducing power, 2,2-diphenyl-1-picrylhydrazyl radical and phosphomolybdenum assays. The hepatotoxicity and nephrotoxicity effects were studied using carbon tetrachloride (CCl )-induced liver and renal injuries in mice. The analgesic activity was explored using the hot-plate and acetic acid tests in mice. Results showed that the methanol fraction of L. europaeum (LEM) had the highest level of total phenolic, total tannin, and flavonoid. HPLC-DAD analysis revealed the presence of twelve compounds among them caffeic acid was the major compound (140.18μg/g of extract). This fraction also showed the best antioxidant activity in vitro in the three used assays. In vivo, in the mice studies, CCl administration induced hepatotoxicity and nephrotoxicity by a significant rise in the levels of serum liver biomarkers (gamma glutamyl transferase, lactate dehydrogenase, and aminotransferases) and serum renal biomarkers (urea, creatinine, and uric acid). Similarly, levels of lipid peroxidation (MDA) in both tissues were found increased by CCl intoxication. Pretreatment with LEM and quercetin significantly restored the majority of these biological parameters to normal levels, as well as an improvement of histopathological changes. In addition, LEM showed an interesting analgesic activity. LEM decreased significantly the number of writhing induced by acetic acid and prolonged the reaction time in response to thermal stimulus in mice. Therefore, it was speculated that the obtained results highlighted the potential use of L. europaeum as a source of bioactive compounds with pharmacological advantages.
[Display omitted] In this study, the antioxidant, antinociceptive, hepatoprotective, nephroprotective properties and the bioactive composition of Lycium europaeum were investigated. Polyphenols and total tannin contents were measured by colorimetric methods The antioxidant activity in vitro was evaluated using the reducing power, 2,2-diphenyl-1-picrylhydrazyl radical and phosphomolybdenum assays. The hepatotoxicity and nephrotoxicity effects were studied using carbon tetrachloride (CCl4)-induced liver and renal injuries in mice. The analgesic activity was explored using the hot-plate and acetic acid tests in mice. Results showed that the methanol fraction of L. europaeum (LEM) had the highest level of total phenolic, total tannin, and flavonoid. HPLC-DAD analysis revealed the presence of twelve compounds among them caffeic acid was the major compound (140.18μg/g of extract). This fraction also showed the best antioxidant activity in vitro in the three used assays. In vivo, in the mice studies, CCl4 administration induced hepatotoxicity and nephrotoxicity by a significant rise in the levels of serum liver biomarkers (gamma glutamyl transferase, lactate dehydrogenase, and aminotransferases) and serum renal biomarkers (urea, creatinine, and uric acid). Similarly, levels of lipid peroxidation (MDA) in both tissues were found increased by CCl4 intoxication. Pretreatment with LEM and quercetin significantly restored the majority of these biological parameters to normal levels, as well as an improvement of histopathological changes. In addition, LEM showed an interesting analgesic activity. LEM decreased significantly the number of writhing induced by acetic acid and prolonged the reaction time in response to thermal stimulus in mice. Therefore, it was speculated that the obtained results highlighted the potential use of L. europaeum as a source of bioactive compounds with pharmacological advantages
Author Sdayria, Jazia
Hfaiedh, Najla
Rjeibi, Ilhem
Ncib, Sana
Feriani, Anouar
Souid, Sami
Allagui, Mohamed Salah
Ben Saad, Anouar
Saidi, Issam
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  organization: Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia
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Cites_doi 10.1016/j.fct.2011.10.063
10.1016/j.pmn.2005.08.003
10.1016/j.foodchem.2010.03.120
10.1016/j.acthis.2014.05.004
10.1016/j.jep.2012.01.001
10.1038/aps.2012.62
10.1016/j.foodchem.2005.07.057
10.1016/0076-6879(90)86135-I
10.1016/S0168-0102(01)00289-9
10.1016/j.indcrop.2016.09.021
10.1001/jama.2014.9405
10.1021/jf980366j
10.3390/molecules190710056
10.1016/j.foodchem.2010.03.074
10.1080/10715760100301281
10.1021/jf0209701
10.1016/j.foodchem.2016.06.072
10.1016/j.biopha.2016.12.078
10.1016/j.foodchem.2017.03.019
10.1016/j.etp.2011.01.012
10.1016/S0006-2952(01)00773-0
10.1016/j.bcp.2004.08.002
10.1016/0308-8146(92)90170-7
10.1039/C3AY41807C
10.1039/C4RA07261H
10.1016/j.foodchem.2014.11.114
10.1016/S0944-7113(97)80070-0
10.1016/j.bbr.2006.06.030
10.1016/j.foodchem.2007.03.059
10.1016/j.fct.2010.10.015
10.1016/j.clinbiochem.2010.07.022
10.1002/(SICI)1099-1573(199703)11:2<101::AID-PTR28>3.0.CO;2-U
10.1016/j.jfda.2014.10.002
10.1016/j.jff.2015.07.004
10.1023/B:CONC.0000018104.98378.e2
10.1021/jf00055a012
10.1016/j.chroma.2010.04.069
10.1016/j.biocel.2006.07.001
10.1007/s12199-016-0581-8
10.1016/S2095-3119(14)60824-8
10.1016/j.phrs.2016.11.019
10.1016/j.foodchem.2009.01.079
10.1007/s11947-011-0625-4
10.3923/jbs.2017.35.41
10.1016/j.jep.2005.05.039
10.1016/j.fct.2016.11.018
10.1186/1472-6882-12-178
10.1016/j.indcrop.2014.10.029
10.1016/j.sajb.2017.06.004
10.1080/14756366.2016.1243535
10.3892/br.2014.267
10.1016/S0021-9258(19)52451-6
10.1007/s10519-013-9593-y
10.3390/ijms161125942
10.1080/01635581.2015.1017054
10.1016/j.jep.2004.09.054
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Keywords Kidneys
Analgesis
Bioactive compounds
Liver
CCl4
Lycium europaeum
Antioxidant
CCl
Language English
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References Thakur, Saini, Mahajan, Singh, Dinkar, Mishra, Kunnumakkara (bib0315) 2017; 115
Koster, Anderson, de Beer (bib0095) 1959; 18
Domitrović, Jakovac, Marchesi, Vladimir-Knežević, Cvijanović (bib0080) 2012; 33
Sahreen, Khan, Khan (bib0050) 2010; 122
Yoshioka, Tanaka, Fujii, Nonogaki (bib0220) 2016; 21
El Denshary, Al-Gahazali, Mannaa, Salem, Hassan, Abdel-Wahhab (bib0240) 2012; 64
Abdennacer, Karim, Nesrine, Mouna, Mohamed (bib0145) 2015; 174
Desai, Patel, Devkar, Patel, Ramachandran (bib0235) 2012; 50
Houda, Derbré, Jedy, Tlili, Legault, Richomme, Limam, Saidani-Tounsi (bib0055) 2014; 13
Ha, Yoon, Choi, Kim, Kim, Kim (bib0270) 2005; 96
Bounatirou, Smiti, Miguel, Faleiro, Rejeb, Neffati (bib0075) 2007; 105
Boutennoun, Boussouf, Kebieche, Al-Qaoud, Madani (bib0310) 2017; 112
Lowry, Rosebrough, Farr, Randall (bib0085) 1951; 193
Huang, Ke, He, Ban, Zeng, Wang (bib0115) 2011; 49
Rokbeni, M’rabet, Cluzet, Richard, Krisa, Boussaid, Boulila (bib0200) 2016; 94
Chen, Pearson, Gray (bib0010) 1992; 43
Meir, Kanner, Akiri, Philosoph-Hadas (bib0205) 1995; 43
Chi, Jong, Son, Chang, Kang, Kim (bib0300) 2001; 62
Hacimuftuoglu, Handy, Goettl, Lin, Dane, Stephens (bib0320) 2006; 173
Neffati, Akrimi (bib0040) 1996; 4
Feng, Kumagai, Torii, Nakamura, Osawa, Uchida (bib0265) 2001; 35
Heimler, Vignolini, Dini, Vincieri, Romani (bib0070) 2006; 99
Shin, Kim, Park, Ha, Choi, Park, Lee (bib0190) 2004; 68
Khan, Khan, Sahreen (bib0170) 2012; 12
Valko, Leibfritz, Moncol, Cronin, Mazur, Telser (bib0005) 2007; 39
Zhao, Zhang, Dai, Zhang, Ye, Li (bib0185) 2014; 4
Mocan, Zengin, Simirgiotis, Schafberg, Mollica, Vodnar, Crisan, Rohn (bib0140) 2017; 32
Makris, Abrams, Gurland, Reid (bib0280) 2014; 312
Song, Yen (bib0275) 2003; 51
Wang, Tang, Zhang (bib0175) 2015; 23
Kosar, Altintas, Kirimer, Baser (bib0155) 2003; 39
Mbarki, Alimi, Bouzenna, Elfeki, Hfaiedh (bib0215) 2017; 88
Sun, Ricardo-da-Silva, Spranger (bib0060) 1998; 46
Verma, Joharapurkar, Chatpalliwar, Asnani (bib0295) 2005; 102
Pirinccioglu, Gökalp, Pirinccioglu, Kizil, Kizil (bib0255) 2010; 43
Ghali, Vaudry, Jouenne, Marzouki (bib0020) 2015; 67
Mohd-Esa, Hern, Ismail, Yee (bib0125) 2010; 122
Lin, Chuang, Lin, Yang (bib0030) 1997; 4
Ahn, Park, Chae, Kim, Moon, Hyun, Shin (bib0225) 2014; 116
Prasad, Yang, Yang, Chen, Zhao, Ashraf, Jiang (bib0065) 2009; 116
Megdiche-Ksouri, Trabelsi, Mkadmini, Bourgou, Noumi, Snoussi, Barbriad, Tebourbi, Ksouri (bib0120) 2015; 63
Ito, Okuda-Ashitaka, Minami (bib0290) 2001; 41
Pottier-Alapetite (bib0035) 1981
Hu, Zhao (bib0165) 2014; 2
Liu, Lin, Hu, Shen, Chen, Chang, Yang (bib0210) 2017; 215
Khaled Alharbi, Mousa, Ibrahim, El-Ashmawy (bib0250) 2017; 17
Dewey, Harris, Howes, Nuite (bib0105) 1970; 175
Kalantari, Foruozandeh, Khodayar, Siahpoosh, Saki, Kheradmand (bib0160) 2017
Wirth, Hudgins, Paice (bib0025) 2005; 6
Magnani, Isaac, Correa, Salgado (bib0180) 2014; 6
Wirth, Hudgins, Paice (bib0285) 2005; 6
Rebey, Bourgou, Debez, Karoui, Sellami, Msaada, Limam, Marzouk (bib0110) 2012; 5
Van Beek, de Moor, de Geus, Lubke, Vink, Willemsen, Boomsma (bib0230) 2013; 43
Duan, Chen, Chen (bib0135) 2010; 1217
Draper, Hadley (bib0090) 1990; 186
Vaz, Mata, Calixto (bib0100) 1997; 11
Rosa, Maxia, Putzu, Atzeri, Era, Fais, Piras (bib0045) 2017; 230
Koleckar, Kubikova, Rehakova, Kuca, Jun, Jahodar, Opletal (bib0130) 2008; 8
Li, Tan, Wang, Zhang, Lao, Wong, Feng (bib0260) 2015; 16
Mocan, Vlase, Vodnar, Bischin, Hanganu, Gheldiu, Oprean, Silaghi-Dumitrescu, Crișan (bib0150) 2014; 19
Katanic, Mihailovic, Matic, Stankovic, Stankovic, Boroja, Mladenovic, Stanic, Kreft, Mihailovic (bib0245) 2015; 18
Loganayaki, Siddhuraju, Manian (bib0305) 2012; 140
Katanić, Matić, Pferschy-Wenzig, Kretschmer, Boroja, Mihailović, Stanic, Kreft, Mihailović (bib0015) 2017; 99
Jiang, Zhang, Zhang, Chen, Ma, Wu, Mu, Chen (bib0195) 2015; 14
Prasad (10.1016/j.biopha.2017.09.035_bib0065) 2009; 116
Khaled Alharbi (10.1016/j.biopha.2017.09.035_bib0250) 2017; 17
Shin (10.1016/j.biopha.2017.09.035_bib0190) 2004; 68
Koleckar (10.1016/j.biopha.2017.09.035_bib0130) 2008; 8
Katanić (10.1016/j.biopha.2017.09.035_bib0015) 2017; 99
Wang (10.1016/j.biopha.2017.09.035_bib0175) 2015; 23
Dewey (10.1016/j.biopha.2017.09.035_bib0105) 1970; 175
Jiang (10.1016/j.biopha.2017.09.035_bib0195) 2015; 14
Van Beek (10.1016/j.biopha.2017.09.035_bib0230) 2013; 43
Mocan (10.1016/j.biopha.2017.09.035_bib0140) 2017; 32
Mohd-Esa (10.1016/j.biopha.2017.09.035_bib0125) 2010; 122
Zhao (10.1016/j.biopha.2017.09.035_bib0185) 2014; 4
Meir (10.1016/j.biopha.2017.09.035_bib0205) 1995; 43
Vaz (10.1016/j.biopha.2017.09.035_bib0100) 1997; 11
Khan (10.1016/j.biopha.2017.09.035_bib0170) 2012; 12
Feng (10.1016/j.biopha.2017.09.035_bib0265) 2001; 35
Chen (10.1016/j.biopha.2017.09.035_bib0010) 1992; 43
Magnani (10.1016/j.biopha.2017.09.035_bib0180) 2014; 6
Katanic (10.1016/j.biopha.2017.09.035_bib0245) 2015; 18
Lin (10.1016/j.biopha.2017.09.035_bib0030) 1997; 4
Sun (10.1016/j.biopha.2017.09.035_bib0060) 1998; 46
Rokbeni (10.1016/j.biopha.2017.09.035_bib0200) 2016; 94
Hacimuftuoglu (10.1016/j.biopha.2017.09.035_bib0320) 2006; 173
Kalantari (10.1016/j.biopha.2017.09.035_bib0160) 2017
Thakur (10.1016/j.biopha.2017.09.035_bib0315) 2017; 115
Ahn (10.1016/j.biopha.2017.09.035_bib0225) 2014; 116
Desai (10.1016/j.biopha.2017.09.035_bib0235) 2012; 50
Ito (10.1016/j.biopha.2017.09.035_bib0290) 2001; 41
Rebey (10.1016/j.biopha.2017.09.035_bib0110) 2012; 5
Ha (10.1016/j.biopha.2017.09.035_bib0270) 2005; 96
Pirinccioglu (10.1016/j.biopha.2017.09.035_bib0255) 2010; 43
Houda (10.1016/j.biopha.2017.09.035_bib0055) 2014; 13
Domitrović (10.1016/j.biopha.2017.09.035_bib0080) 2012; 33
Lowry (10.1016/j.biopha.2017.09.035_bib0085) 1951; 193
Wirth (10.1016/j.biopha.2017.09.035_bib0285) 2005; 6
Liu (10.1016/j.biopha.2017.09.035_bib0210) 2017; 215
Abdennacer (10.1016/j.biopha.2017.09.035_bib0145) 2015; 174
Wirth (10.1016/j.biopha.2017.09.035_bib0025) 2005; 6
Boutennoun (10.1016/j.biopha.2017.09.035_bib0310) 2017; 112
Draper (10.1016/j.biopha.2017.09.035_bib0090) 1990; 186
Song (10.1016/j.biopha.2017.09.035_bib0275) 2003; 51
Yoshioka (10.1016/j.biopha.2017.09.035_bib0220) 2016; 21
Ghali (10.1016/j.biopha.2017.09.035_bib0020) 2015; 67
Huang (10.1016/j.biopha.2017.09.035_bib0115) 2011; 49
Valko (10.1016/j.biopha.2017.09.035_bib0005) 2007; 39
Loganayaki (10.1016/j.biopha.2017.09.035_bib0305) 2012; 140
Mbarki (10.1016/j.biopha.2017.09.035_bib0215) 2017; 88
Sahreen (10.1016/j.biopha.2017.09.035_bib0050) 2010; 122
Hu (10.1016/j.biopha.2017.09.035_bib0165) 2014; 2
Neffati (10.1016/j.biopha.2017.09.035_bib0040) 1996; 4
Makris (10.1016/j.biopha.2017.09.035_bib0280) 2014; 312
Kosar (10.1016/j.biopha.2017.09.035_bib0155) 2003; 39
Megdiche-Ksouri (10.1016/j.biopha.2017.09.035_bib0120) 2015; 63
El Denshary (10.1016/j.biopha.2017.09.035_bib0240) 2012; 64
Verma (10.1016/j.biopha.2017.09.035_bib0295) 2005; 102
Duan (10.1016/j.biopha.2017.09.035_bib0135) 2010; 1217
Koster (10.1016/j.biopha.2017.09.035_bib0095) 1959; 18
Heimler (10.1016/j.biopha.2017.09.035_bib0070) 2006; 99
Pottier-Alapetite (10.1016/j.biopha.2017.09.035_bib0035) 1981
Rosa (10.1016/j.biopha.2017.09.035_bib0045) 2017; 230
Mocan (10.1016/j.biopha.2017.09.035_bib0150) 2014; 19
Li (10.1016/j.biopha.2017.09.035_bib0260) 2015; 16
Bounatirou (10.1016/j.biopha.2017.09.035_bib0075) 2007; 105
Chi (10.1016/j.biopha.2017.09.035_bib0300) 2001; 62
References_xml – volume: 21
  start-page: 554
  year: 2016
  end-page: 562
  ident: bib0220
  article-title: extract suppresses carbon tetrachloride-induced hepato-and nephrotoxicity in mice
  publication-title: Environ. Health Prev. Med.
  contributor:
    fullname: Nonogaki
– volume: 5
  start-page: 2827
  year: 2012
  end-page: 2836
  ident: bib0110
  article-title: Effects of extraction solvents and provenances on phenolic contents and antioxidant activities of cumin (
  publication-title: Food Bioprocess. Technol.
  contributor:
    fullname: Marzouk
– volume: 49
  start-page: 185
  year: 2011
  end-page: 190
  ident: bib0115
  article-title: Extracts of Halenia elliptica exhibit antioxidant properties in vitro and in vivo
  publication-title: Food Chem. Toxicol.
  contributor:
    fullname: Wang
– volume: 6
  start-page: 145
  year: 2005
  end-page: 167.7
  ident: bib0025
  article-title: Use of herbal therapies to relieve pain: a review of efficacy and adverse effects
  publication-title: Pain Manag. Nurs.
  contributor:
    fullname: Paice
– volume: 122
  start-page: 1055
  year: 2010
  end-page: 1060
  ident: bib0125
  article-title: Antioxidant activity in different parts of roselle (
  publication-title: Food Chem.
  contributor:
    fullname: Yee
– volume: 19
  start-page: 10056
  year: 2014
  end-page: 10073
  ident: bib0150
  article-title: Polyphenolic content, antioxidant and antimicrobial activities of
  publication-title: Molecules
  contributor:
    fullname: Crișan
– volume: 6
  start-page: 145
  year: 2005
  end-page: 167
  ident: bib0285
  article-title: Use of herbal therapies to relieve pain: a review of efficacy and adverse effects
  publication-title: Pain. Manag. Nurs.
  contributor:
    fullname: Paice
– volume: 230
  start-page: 82
  year: 2017
  end-page: 90
  ident: bib0045
  article-title: Chemical composition of Lycium europaeum fruit oil obtained by supercritical CO
  publication-title: Food Chem.
  contributor:
    fullname: Piras
– volume: 102
  start-page: 298
  year: 2005
  end-page: 301
  ident: bib0295
  article-title: Antinociceptive activity of alcoholic extract of
  publication-title: J. Ethnopharmacol.
  contributor:
    fullname: Asnani
– volume: 32
  start-page: 153
  year: 2017
  end-page: 168
  ident: bib0140
  article-title: Functional constituents of wild and cultivated Goji (
  publication-title: J. Enzym. Inhib. Med. Chem.
  contributor:
    fullname: Rohn
– volume: 122
  start-page: 1205
  year: 2010
  end-page: 1211
  ident: bib0050
  article-title: Evaluation of antioxidant activities of various solvent extracts of Carissa opaca fruits
  publication-title: Food Chem.
  contributor:
    fullname: Khan
– volume: 6
  start-page: 3203
  year: 2014
  end-page: 3210
  ident: bib0180
  article-title: Caffeic acid: a review of its potential use in medications and cosmetics
  publication-title: Anal. Methods
  contributor:
    fullname: Salgado
– volume: 173
  start-page: 211
  year: 2006
  end-page: 216
  ident: bib0320
  article-title: Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice
  publication-title: Behav. Brain. Res.
  contributor:
    fullname: Stephens
– volume: 4
  start-page: 309
  year: 1996
  end-page: 3013
  ident: bib0040
  article-title: Banque de gènes des plantes pastorales de la zone aride et désertique
  publication-title: Forêt méditelerranéenne. T. XVII
  contributor:
    fullname: Akrimi
– volume: 18
  start-page: 412
  year: 1959
  ident: bib0095
  article-title: Acetic acid for analgesic screening
  publication-title: Fed. Proc.
  contributor:
    fullname: de Beer
– volume: 14
  start-page: 758
  year: 2015
  end-page: 764
  ident: bib0195
  article-title: Influence of gallic acid on porcine neutrophils phosphodiesterase 4, IL-6 TNF- alpha and rat arthritis model
  publication-title: J. Integr. Agric.
  contributor:
    fullname: Chen
– volume: 175
  start-page: 435
  year: 1970
  end-page: 442
  ident: bib0105
  article-title: The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests
  publication-title: J. Pharmacol. Exp. Ther.
  contributor:
    fullname: Nuite
– volume: 16
  start-page: 26087
  year: 2015
  end-page: 26124
  ident: bib0260
  article-title: The role of oxidative stress and antioxidants in liver diseases
  publication-title: Inter. J. Mol. Sci.
  contributor:
    fullname: Feng
– volume: 215
  start-page: 284
  year: 2017
  end-page: 291
  ident: bib0210
  article-title: Phenolic compositions and antioxidant attributes of leaves and stems from three inbred varieties of
  publication-title: Food Chem.
  contributor:
    fullname: Yang
– volume: 88
  start-page: 19
  year: 2017
  end-page: 26
  ident: bib0215
  article-title: Phytochemical study and protective effect of
  publication-title: Biomed. Pharmacother.
  contributor:
    fullname: Hfaiedh
– volume: 67
  start-page: 637
  year: 2015
  end-page: 646
  ident: bib0020
  article-title: Lycium Europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells
  publication-title: Nutr. Cancer
  contributor:
    fullname: Marzouki
– volume: 186
  start-page: 421
  year: 1990
  end-page: 431
  ident: bib0090
  article-title: Malondialdehyde determination as index of lipid peroxidation
  publication-title: Methods Enzymol.
  contributor:
    fullname: Hadley
– volume: 2
  start-page: 569
  year: 2014
  end-page: 573
  ident: bib0165
  article-title: Analgesic effects of naringenin in rats with spinal nerve ligation-induced neuropathic pain
  publication-title: Biomed. Rep.
  contributor:
    fullname: Zhao
– volume: 140
  start-page: 230
  year: 2012
  end-page: 233
  ident: bib0305
  article-title: Antioxidant, anti-inflammatory and anti-nociceptive effects of
  publication-title: J. Ethnopharmacol.
  contributor:
    fullname: Manian
– volume: 116
  start-page: 1
  year: 2009
  end-page: 7
  ident: bib0065
  article-title: Identification of phenolic compounds and appraisal of antioxidant and antityrosinase activities from litchi (
  publication-title: Food Chem.
  contributor:
    fullname: Jiang
– start-page: 1
  year: 2017
  end-page: 8
  ident: bib0160
  article-title: Antioxidant and hepatoprotective effects of
  publication-title: J. Tradit. Complement. Med.
  contributor:
    fullname: Kheradmand
– volume: 116
  start-page: 1104
  year: 2014
  end-page: 1112
  ident: bib0225
  article-title: Hepatoprotective effects of
  publication-title: Acta Histochem.
  contributor:
    fullname: Shin
– volume: 43
  start-page: 1220
  year: 2010
  end-page: 1224
  ident: bib0255
  article-title: Malondialdehyde (MDA) and protein carbonyl (PCO) levels as biomarkers of oxidative stress in subjects with familial hypercholesterolemia
  publication-title: Clin. Biochem.
  contributor:
    fullname: Kizil
– volume: 62
  start-page: 1185
  year: 2001
  end-page: 1191
  ident: bib0300
  article-title: Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases
  publication-title: Biochem. Pharmacol.
  contributor:
    fullname: Kim
– volume: 105
  start-page: 149
  year: 2007
  end-page: 153
  ident: bib0075
  article-title: Chemical composition, antioxidant and antibacterial activities of the essential oils isolated from Tunisian Thymus capitatus Hoff. et Link
  publication-title: Food Chem.
  contributor:
    fullname: Neffati
– volume: 39
  start-page: 44
  year: 2007
  end-page: 84
  ident: bib0005
  article-title: Free radicals and antioxidants in normal physiological functions and human disease
  publication-title: Int. J. Biochem Cell. Biol.
  contributor:
    fullname: Telser
– volume: 96
  start-page: 529
  year: 2005
  end-page: 535
  ident: bib0270
  article-title: Protective effect of
  publication-title: J. Ethnopharmacol.
  contributor:
    fullname: Kim
– volume: 43
  start-page: 1813
  year: 1995
  end-page: 1819
  ident: bib0205
  article-title: Determination and involvement of aqueous reducing compounds in oxidative defense systems of various senescing leaves
  publication-title: J. Agric. Food Chem.
  contributor:
    fullname: Philosoph-Hadas
– volume: 43
  start-page: 177
  year: 1992
  end-page: 183
  ident: bib0010
  article-title: Effects of synthetic antioxidants (BHA, BHT and PG) on the mutagenicity of IQ-like compounds
  publication-title: Food Chem.
  contributor:
    fullname: Gray
– volume: 4
  start-page: 43057
  year: 2014
  end-page: 43063
  ident: bib0185
  article-title: Synergistic protective effect of chlorogenic acid, apigenin and caffeic acid against carbon tetrachloride-induced hepatotoxicity in male mice
  publication-title: RSC Adv.
  contributor:
    fullname: Li
– volume: 68
  start-page: 2327
  year: 2004
  end-page: 2336
  ident: bib0190
  article-title: Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E 2, nitric oxide and tumor necrosis factor-α production
  publication-title: Biochem. Pharmacol.
  contributor:
    fullname: Lee
– volume: 33
  start-page: 1260
  year: 2012
  end-page: 1270
  ident: bib0080
  article-title: Ž. Tadić D.Rahelić, Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice
  publication-title: Acta Pharmacol. Sin.
  contributor:
    fullname: Cvijanović
– volume: 46
  start-page: 4267
  year: 1998
  end-page: 4274
  ident: bib0060
  article-title: Critical factors of vanillin assay for catechins and proanthocyanidins
  publication-title: J. Agric. Food Chem.
  contributor:
    fullname: Spranger
– volume: 193
  start-page: 265
  year: 1951
  end-page: 275
  ident: bib0085
  article-title: Protein measurement with the Folin phenol reagent
  publication-title: J. Biol Chem.
  contributor:
    fullname: Randall
– volume: 51
  start-page: 1571
  year: 2003
  end-page: 1577
  ident: bib0275
  article-title: Protective effects of fermented filtrate from
  publication-title: J. Agric. Food Chem.
  contributor:
    fullname: Yen
– volume: 39
  start-page: 531
  year: 2003
  end-page: 535
  ident: bib0155
  article-title: Determination of the free radical scavenging activity of
  publication-title: Chem. Nat. Comp.
  contributor:
    fullname: Baser
– volume: 50
  start-page: 310
  year: 2012
  end-page: 314
  ident: bib0235
  article-title: Hepatoprotective potential of polyphenol rich extract of
  publication-title: Food Chem. Toxicol.
  contributor:
    fullname: Ramachandran
– volume: 112
  start-page: 307
  year: 2017
  end-page: 313
  ident: bib0310
  article-title: analgesic: anti-inflammatory and antioxidant potentials of
  publication-title: S. Afr. J. Bot.
  contributor:
    fullname: Madani
– volume: 23
  start-page: 310
  year: 2015
  end-page: 317
  ident: bib0175
  article-title: Hepatoprotective effects of kaempferol 3-O-rutinoside and kaempferol 3-O-glucoside from
  publication-title: J. Food Drug Anal.
  contributor:
    fullname: Zhang
– volume: 11
  start-page: 101
  year: 1997
  end-page: 110
  ident: bib0100
  article-title: Analgesic effect of the herbal medicine catuama in thermal and chemical models of nociception in mice
  publication-title: Phytother. Res.
  contributor:
    fullname: Calixto
– volume: 312
  start-page: 825
  year: 2014
  end-page: 837
  ident: bib0280
  article-title: Management of persistent pain in the older patient: a clinical review
  publication-title: JAMA
  contributor:
    fullname: Reid
– volume: 17
  start-page: 35
  year: 2017
  end-page: 41
  ident: bib0250
  article-title: Hepatoprotective effect of methanolic extracts of Prosopis farcta and
  publication-title: J. Biol. Sci.
  contributor:
    fullname: El-Ashmawy
– volume: 4
  start-page: 213
  year: 1997
  end-page: 220
  ident: bib0030
  article-title: Evaluation of the antiinflammatory hepatoprotective and antioxidant activities of Lycium chinense from Taiwan
  publication-title: Phytomedicine
  contributor:
    fullname: Yang
– volume: 12
  start-page: 178
  year: 2012
  ident: bib0170
  article-title: CCl 4-induced hepatotoxicity: protective effect of rutin on p53 CYP2E1 and the antioxidative status in rat
  publication-title: BMC Complement. Alter. Med.
  contributor:
    fullname: Sahreen
– volume: 174
  start-page: 577
  year: 2015
  end-page: 584
  ident: bib0145
  article-title: Determination of phytochemicals and antioxidant activity of methanol extracts obtained from the fruit and leaves of Tunisian
  publication-title: Food Chem.
  contributor:
    fullname: Mohamed
– volume: 35
  start-page: 779
  year: 2001
  end-page: 788
  ident: bib0265
  article-title: Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress
  publication-title: Free Radic. Res.
  contributor:
    fullname: Uchida
– volume: 43
  start-page: 329
  year: 2013
  end-page: 339
  ident: bib0230
  article-title: The genetic architecture of liver enzyme levels: GGT, ALT and AST
  publication-title: Behav. Genet.
  contributor:
    fullname: Boomsma
– volume: 63
  start-page: 104
  year: 2015
  end-page: 113
  ident: bib0120
  article-title: phenolic compounds have antioxidant and antimicrobial activity
  publication-title: Ind. Crop Prod.
  contributor:
    fullname: Ksouri
– volume: 99
  start-page: 464
  year: 2006
  end-page: 469
  ident: bib0070
  article-title: Antiradical activity and polyphenol composition of local Brassicaceae edible varieties
  publication-title: Food Chem.
  contributor:
    fullname: Romani
– start-page: 816
  year: 1981
  end-page: 817
  ident: bib0035
  article-title: Flore de la Tunisie Angiospermes-Dicotylédones, Apétales Dialypétales
  publication-title: Imprimerie Officielle de la République Tunisienne
  contributor:
    fullname: Pottier-Alapetite
– volume: 13
  start-page: 1029
  year: 2014
  end-page: 1042
  ident: bib0055
  article-title: Combined anti-ages and antioxidant activities of different solvent extracts of Solanum elaeagnifolium cav (solanacea) fruits during ripeningand related to their phytochemical compositions
  publication-title: Excli J.
  contributor:
    fullname: Saidani-Tounsi
– volume: 115
  start-page: 224
  year: 2017
  end-page: 232
  ident: bib0315
  article-title: Therapeutic implications of toll-like receptors in peripheral neuropathic pain
  publication-title: Pharmacol. Res.
  contributor:
    fullname: Kunnumakkara
– volume: 8
  start-page: 436
  year: 2008
  end-page: 447
  ident: bib0130
  article-title: Condensed and hydrolysable tannins as antioxidants influencing the health, Mini reviews
  publication-title: Medicinal Chem.
  contributor:
    fullname: Opletal
– volume: 41
  start-page: 299
  year: 2001
  end-page: 332
  ident: bib0290
  article-title: Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin
  publication-title: Neurosci. Res.
  contributor:
    fullname: Minami
– volume: 1217
  start-page: 4511
  year: 2010
  end-page: 4516
  ident: bib0135
  article-title: Far infrared-assisted extraction followed by capillary electrophoresis for the determination of bioactive constituents in the leaves of
  publication-title: J. Chromatogr. A
  contributor:
    fullname: Chen
– volume: 94
  start-page: 505
  year: 2016
  end-page: 513
  ident: bib0200
  article-title: Determination of phenolic composition and antioxidant activities of
  publication-title: Ind. Crop Prod.
  contributor:
    fullname: Boulila
– volume: 99
  start-page: 86
  year: 2017
  end-page: 102
  ident: bib0015
  article-title: extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: in vivo investigation and LC–MS analysis
  publication-title: Food Chem. Toxicol.
  contributor:
    fullname: Mihailović
– volume: 64
  start-page: 753
  year: 2012
  end-page: 760
  ident: bib0240
  article-title: Dietary honey and ginseng protect against carbon tetrachloride-induced hepatonephrotoxicity in rats
  publication-title: Exp. Toxicol. Pathol.
  contributor:
    fullname: Abdel-Wahhab
– volume: 18
  start-page: 198
  year: 2015
  end-page: 212
  ident: bib0245
  article-title: The ameliorating effect of
  publication-title: J. Funct. Foods
  contributor:
    fullname: Mihailovic
– volume: 50
  start-page: 310
  year: 2012
  ident: 10.1016/j.biopha.2017.09.035_bib0235
  article-title: Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: an in vivo study
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2011.10.063
  contributor:
    fullname: Desai
– volume: 6
  start-page: 145
  year: 2005
  ident: 10.1016/j.biopha.2017.09.035_bib0285
  article-title: Use of herbal therapies to relieve pain: a review of efficacy and adverse effects
  publication-title: Pain. Manag. Nurs.
  doi: 10.1016/j.pmn.2005.08.003
  contributor:
    fullname: Wirth
– volume: 6
  start-page: 145
  year: 2005
  ident: 10.1016/j.biopha.2017.09.035_bib0025
  article-title: Use of herbal therapies to relieve pain: a review of efficacy and adverse effects
  publication-title: Pain Manag. Nurs.
  doi: 10.1016/j.pmn.2005.08.003
  contributor:
    fullname: Wirth
– volume: 122
  start-page: 1205
  year: 2010
  ident: 10.1016/j.biopha.2017.09.035_bib0050
  article-title: Evaluation of antioxidant activities of various solvent extracts of Carissa opaca fruits
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2010.03.120
  contributor:
    fullname: Sahreen
– volume: 116
  start-page: 1104
  year: 2014
  ident: 10.1016/j.biopha.2017.09.035_bib0225
  article-title: Hepatoprotective effects of Lycium chinense Miller fruit and its constituent betaine in CCl 4-induced hepatic damage in rats
  publication-title: Acta Histochem.
  doi: 10.1016/j.acthis.2014.05.004
  contributor:
    fullname: Ahn
– volume: 140
  start-page: 230
  year: 2012
  ident: 10.1016/j.biopha.2017.09.035_bib0305
  article-title: Antioxidant, anti-inflammatory and anti-nociceptive effects of Ammannia baccifera L. (Lythracceae), a folklore medicinal plant
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2012.01.001
  contributor:
    fullname: Loganayaki
– start-page: 816
  year: 1981
  ident: 10.1016/j.biopha.2017.09.035_bib0035
  article-title: Flore de la Tunisie Angiospermes-Dicotylédones, Apétales Dialypétales
  publication-title: Imprimerie Officielle de la République Tunisienne
  contributor:
    fullname: Pottier-Alapetite
– volume: 33
  start-page: 1260
  year: 2012
  ident: 10.1016/j.biopha.2017.09.035_bib0080
  article-title: Ž. Tadić D.Rahelić, Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/aps.2012.62
  contributor:
    fullname: Domitrović
– volume: 4
  start-page: 309
  year: 1996
  ident: 10.1016/j.biopha.2017.09.035_bib0040
  article-title: Banque de gènes des plantes pastorales de la zone aride et désertique
  publication-title: Forêt méditelerranéenne. T. XVII
  contributor:
    fullname: Neffati
– volume: 99
  start-page: 464
  year: 2006
  ident: 10.1016/j.biopha.2017.09.035_bib0070
  article-title: Antiradical activity and polyphenol composition of local Brassicaceae edible varieties
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2005.07.057
  contributor:
    fullname: Heimler
– volume: 186
  start-page: 421
  year: 1990
  ident: 10.1016/j.biopha.2017.09.035_bib0090
  article-title: Malondialdehyde determination as index of lipid peroxidation
  publication-title: Methods Enzymol.
  doi: 10.1016/0076-6879(90)86135-I
  contributor:
    fullname: Draper
– volume: 41
  start-page: 299
  year: 2001
  ident: 10.1016/j.biopha.2017.09.035_bib0290
  article-title: Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin
  publication-title: Neurosci. Res.
  doi: 10.1016/S0168-0102(01)00289-9
  contributor:
    fullname: Ito
– volume: 94
  start-page: 505
  year: 2016
  ident: 10.1016/j.biopha.2017.09.035_bib0200
  article-title: Determination of phenolic composition and antioxidant activities of Pancratium maritimum L. from Tunisia
  publication-title: Ind. Crop Prod.
  doi: 10.1016/j.indcrop.2016.09.021
  contributor:
    fullname: Rokbeni
– volume: 312
  start-page: 825
  year: 2014
  ident: 10.1016/j.biopha.2017.09.035_bib0280
  article-title: Management of persistent pain in the older patient: a clinical review
  publication-title: JAMA
  doi: 10.1001/jama.2014.9405
  contributor:
    fullname: Makris
– volume: 46
  start-page: 4267
  year: 1998
  ident: 10.1016/j.biopha.2017.09.035_bib0060
  article-title: Critical factors of vanillin assay for catechins and proanthocyanidins
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf980366j
  contributor:
    fullname: Sun
– volume: 8
  start-page: 436
  year: 2008
  ident: 10.1016/j.biopha.2017.09.035_bib0130
  article-title: Condensed and hydrolysable tannins as antioxidants influencing the health, Mini reviews
  publication-title: Medicinal Chem.
  contributor:
    fullname: Koleckar
– volume: 19
  start-page: 10056
  year: 2014
  ident: 10.1016/j.biopha.2017.09.035_bib0150
  article-title: Polyphenolic content, antioxidant and antimicrobial activities of Lycium barbarum L. and Lycium chinense Mill. leaves
  publication-title: Molecules
  doi: 10.3390/molecules190710056
  contributor:
    fullname: Mocan
– volume: 122
  start-page: 1055
  year: 2010
  ident: 10.1016/j.biopha.2017.09.035_bib0125
  article-title: Antioxidant activity in different parts of roselle (Hibiscus sabdariffa L.) extracts and potential exploitation of the seeds
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2010.03.074
  contributor:
    fullname: Mohd-Esa
– volume: 35
  start-page: 779
  year: 2001
  ident: 10.1016/j.biopha.2017.09.035_bib0265
  article-title: Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress
  publication-title: Free Radic. Res.
  doi: 10.1080/10715760100301281
  contributor:
    fullname: Feng
– volume: 51
  start-page: 1571
  year: 2003
  ident: 10.1016/j.biopha.2017.09.035_bib0275
  article-title: Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf0209701
  contributor:
    fullname: Song
– volume: 215
  start-page: 284
  year: 2017
  ident: 10.1016/j.biopha.2017.09.035_bib0210
  article-title: Phenolic compositions and antioxidant attributes of leaves and stems from three inbred varieties of Lycium chinense Miller harvested at various times
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2016.06.072
  contributor:
    fullname: Liu
– volume: 88
  start-page: 19
  year: 2017
  ident: 10.1016/j.biopha.2017.09.035_bib0215
  article-title: Phytochemical study and protective effect of Trigonella foenum graecum (Fenugreek seeds) against carbon tetrachloride-induced toxicity in liver and kidney of male rat
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2016.12.078
  contributor:
    fullname: Mbarki
– start-page: 1
  year: 2017
  ident: 10.1016/j.biopha.2017.09.035_bib0160
  article-title: Antioxidant and hepatoprotective effects of Capparis spinosa L. fractions and Quercetin on tert-butyl hydroperoxide-induced acute liver damage in mice
  publication-title: J. Tradit. Complement. Med.
  contributor:
    fullname: Kalantari
– volume: 230
  start-page: 82
  year: 2017
  ident: 10.1016/j.biopha.2017.09.035_bib0045
  article-title: Chemical composition of Lycium europaeum fruit oil obtained by supercritical CO2 extraction and evaluation of its antioxidant activity, cytotoxicity and cell absorption
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2017.03.019
  contributor:
    fullname: Rosa
– volume: 175
  start-page: 435
  year: 1970
  ident: 10.1016/j.biopha.2017.09.035_bib0105
  article-title: The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests
  publication-title: J. Pharmacol. Exp. Ther.
  contributor:
    fullname: Dewey
– volume: 64
  start-page: 753
  year: 2012
  ident: 10.1016/j.biopha.2017.09.035_bib0240
  article-title: Dietary honey and ginseng protect against carbon tetrachloride-induced hepatonephrotoxicity in rats
  publication-title: Exp. Toxicol. Pathol.
  doi: 10.1016/j.etp.2011.01.012
  contributor:
    fullname: El Denshary
– volume: 62
  start-page: 1185
  year: 2001
  ident: 10.1016/j.biopha.2017.09.035_bib0300
  article-title: Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/S0006-2952(01)00773-0
  contributor:
    fullname: Chi
– volume: 68
  start-page: 2327
  year: 2004
  ident: 10.1016/j.biopha.2017.09.035_bib0190
  article-title: Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E 2, nitric oxide and tumor necrosis factor-α production
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2004.08.002
  contributor:
    fullname: Shin
– volume: 43
  start-page: 177
  year: 1992
  ident: 10.1016/j.biopha.2017.09.035_bib0010
  article-title: Effects of synthetic antioxidants (BHA, BHT and PG) on the mutagenicity of IQ-like compounds
  publication-title: Food Chem.
  doi: 10.1016/0308-8146(92)90170-7
  contributor:
    fullname: Chen
– volume: 6
  start-page: 3203
  year: 2014
  ident: 10.1016/j.biopha.2017.09.035_bib0180
  article-title: Caffeic acid: a review of its potential use in medications and cosmetics
  publication-title: Anal. Methods
  doi: 10.1039/C3AY41807C
  contributor:
    fullname: Magnani
– volume: 4
  start-page: 43057
  year: 2014
  ident: 10.1016/j.biopha.2017.09.035_bib0185
  article-title: Synergistic protective effect of chlorogenic acid, apigenin and caffeic acid against carbon tetrachloride-induced hepatotoxicity in male mice
  publication-title: RSC Adv.
  doi: 10.1039/C4RA07261H
  contributor:
    fullname: Zhao
– volume: 174
  start-page: 577
  year: 2015
  ident: 10.1016/j.biopha.2017.09.035_bib0145
  article-title: Determination of phytochemicals and antioxidant activity of methanol extracts obtained from the fruit and leaves of Tunisian Lycium intricatum Boiss
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2014.11.114
  contributor:
    fullname: Abdennacer
– volume: 4
  start-page: 213
  year: 1997
  ident: 10.1016/j.biopha.2017.09.035_bib0030
  article-title: Evaluation of the antiinflammatory hepatoprotective and antioxidant activities of Lycium chinense from Taiwan
  publication-title: Phytomedicine
  doi: 10.1016/S0944-7113(97)80070-0
  contributor:
    fullname: Lin
– volume: 173
  start-page: 211
  year: 2006
  ident: 10.1016/j.biopha.2017.09.035_bib0320
  article-title: Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice
  publication-title: Behav. Brain. Res.
  doi: 10.1016/j.bbr.2006.06.030
  contributor:
    fullname: Hacimuftuoglu
– volume: 105
  start-page: 149
  year: 2007
  ident: 10.1016/j.biopha.2017.09.035_bib0075
  article-title: Chemical composition, antioxidant and antibacterial activities of the essential oils isolated from Tunisian Thymus capitatus Hoff. et Link
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2007.03.059
  contributor:
    fullname: Bounatirou
– volume: 49
  start-page: 185
  year: 2011
  ident: 10.1016/j.biopha.2017.09.035_bib0115
  article-title: Extracts of Halenia elliptica exhibit antioxidant properties in vitro and in vivo
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2010.10.015
  contributor:
    fullname: Huang
– volume: 43
  start-page: 1220
  year: 2010
  ident: 10.1016/j.biopha.2017.09.035_bib0255
  article-title: Malondialdehyde (MDA) and protein carbonyl (PCO) levels as biomarkers of oxidative stress in subjects with familial hypercholesterolemia
  publication-title: Clin. Biochem.
  doi: 10.1016/j.clinbiochem.2010.07.022
  contributor:
    fullname: Pirinccioglu
– volume: 11
  start-page: 101
  year: 1997
  ident: 10.1016/j.biopha.2017.09.035_bib0100
  article-title: Analgesic effect of the herbal medicine catuama in thermal and chemical models of nociception in mice
  publication-title: Phytother. Res.
  doi: 10.1002/(SICI)1099-1573(199703)11:2<101::AID-PTR28>3.0.CO;2-U
  contributor:
    fullname: Vaz
– volume: 23
  start-page: 310
  year: 2015
  ident: 10.1016/j.biopha.2017.09.035_bib0175
  article-title: Hepatoprotective effects of kaempferol 3-O-rutinoside and kaempferol 3-O-glucoside from Carthamus tinctorius L. on CCl 4-induced oxidative liver injury in mice
  publication-title: J. Food Drug Anal.
  doi: 10.1016/j.jfda.2014.10.002
  contributor:
    fullname: Wang
– volume: 18
  start-page: 198
  year: 2015
  ident: 10.1016/j.biopha.2017.09.035_bib0245
  article-title: The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin
  publication-title: J. Funct. Foods
  doi: 10.1016/j.jff.2015.07.004
  contributor:
    fullname: Katanic
– volume: 39
  start-page: 531
  year: 2003
  ident: 10.1016/j.biopha.2017.09.035_bib0155
  article-title: Determination of the free radical scavenging activity of Lycium extracts
  publication-title: Chem. Nat. Comp.
  doi: 10.1023/B:CONC.0000018104.98378.e2
  contributor:
    fullname: Kosar
– volume: 43
  start-page: 1813
  year: 1995
  ident: 10.1016/j.biopha.2017.09.035_bib0205
  article-title: Determination and involvement of aqueous reducing compounds in oxidative defense systems of various senescing leaves
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf00055a012
  contributor:
    fullname: Meir
– volume: 1217
  start-page: 4511
  year: 2010
  ident: 10.1016/j.biopha.2017.09.035_bib0135
  article-title: Far infrared-assisted extraction followed by capillary electrophoresis for the determination of bioactive constituents in the leaves of Lycium barbarum Linn
  publication-title: J. Chromatogr. A
  doi: 10.1016/j.chroma.2010.04.069
  contributor:
    fullname: Duan
– volume: 39
  start-page: 44
  year: 2007
  ident: 10.1016/j.biopha.2017.09.035_bib0005
  article-title: Free radicals and antioxidants in normal physiological functions and human disease
  publication-title: Int. J. Biochem Cell. Biol.
  doi: 10.1016/j.biocel.2006.07.001
  contributor:
    fullname: Valko
– volume: 21
  start-page: 554
  year: 2016
  ident: 10.1016/j.biopha.2017.09.035_bib0220
  article-title: Sasa veitchii extract suppresses carbon tetrachloride-induced hepato-and nephrotoxicity in mice
  publication-title: Environ. Health Prev. Med.
  doi: 10.1007/s12199-016-0581-8
  contributor:
    fullname: Yoshioka
– volume: 14
  start-page: 758
  year: 2015
  ident: 10.1016/j.biopha.2017.09.035_bib0195
  article-title: Influence of gallic acid on porcine neutrophils phosphodiesterase 4, IL-6 TNF- alpha and rat arthritis model
  publication-title: J. Integr. Agric.
  doi: 10.1016/S2095-3119(14)60824-8
  contributor:
    fullname: Jiang
– volume: 115
  start-page: 224
  year: 2017
  ident: 10.1016/j.biopha.2017.09.035_bib0315
  article-title: Therapeutic implications of toll-like receptors in peripheral neuropathic pain
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2016.11.019
  contributor:
    fullname: Thakur
– volume: 116
  start-page: 1
  year: 2009
  ident: 10.1016/j.biopha.2017.09.035_bib0065
  article-title: Identification of phenolic compounds and appraisal of antioxidant and antityrosinase activities from litchi (Litchi sinensis Sonn.) seeds
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2009.01.079
  contributor:
    fullname: Prasad
– volume: 5
  start-page: 2827
  year: 2012
  ident: 10.1016/j.biopha.2017.09.035_bib0110
  article-title: Effects of extraction solvents and provenances on phenolic contents and antioxidant activities of cumin (Cuminum cyminum L.) seeds
  publication-title: Food Bioprocess. Technol.
  doi: 10.1007/s11947-011-0625-4
  contributor:
    fullname: Rebey
– volume: 17
  start-page: 35
  year: 2017
  ident: 10.1016/j.biopha.2017.09.035_bib0250
  article-title: Hepatoprotective effect of methanolic extracts of Prosopis farcta and Lycium shawii against carbon tetrachloride-induced hepatotoxicity in rats
  publication-title: J. Biol. Sci.
  doi: 10.3923/jbs.2017.35.41
  contributor:
    fullname: Khaled Alharbi
– volume: 102
  start-page: 298
  year: 2005
  ident: 10.1016/j.biopha.2017.09.035_bib0295
  article-title: Antinociceptive activity of alcoholic extract of Hemidesmus indicus R.Br. in mice
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2005.05.039
  contributor:
    fullname: Verma
– volume: 99
  start-page: 86
  year: 2017
  ident: 10.1016/j.biopha.2017.09.035_bib0015
  article-title: Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: in vivo investigation and LC–MS analysis
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2016.11.018
  contributor:
    fullname: Katanić
– volume: 12
  start-page: 178
  year: 2012
  ident: 10.1016/j.biopha.2017.09.035_bib0170
  article-title: CCl 4-induced hepatotoxicity: protective effect of rutin on p53 CYP2E1 and the antioxidative status in rat
  publication-title: BMC Complement. Alter. Med.
  doi: 10.1186/1472-6882-12-178
  contributor:
    fullname: Khan
– volume: 18
  start-page: 412
  year: 1959
  ident: 10.1016/j.biopha.2017.09.035_bib0095
  article-title: Acetic acid for analgesic screening
  publication-title: Fed. Proc.
  contributor:
    fullname: Koster
– volume: 63
  start-page: 104
  year: 2015
  ident: 10.1016/j.biopha.2017.09.035_bib0120
  article-title: Artemisia campestris phenolic compounds have antioxidant and antimicrobial activity
  publication-title: Ind. Crop Prod.
  doi: 10.1016/j.indcrop.2014.10.029
  contributor:
    fullname: Megdiche-Ksouri
– volume: 112
  start-page: 307
  year: 2017
  ident: 10.1016/j.biopha.2017.09.035_bib0310
  article-title: In vivo analgesic: anti-inflammatory and antioxidant potentials of Achillea odorata from north Algeria
  publication-title: S. Afr. J. Bot.
  doi: 10.1016/j.sajb.2017.06.004
  contributor:
    fullname: Boutennoun
– volume: 32
  start-page: 153
  year: 2017
  ident: 10.1016/j.biopha.2017.09.035_bib0140
  article-title: Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies
  publication-title: J. Enzym. Inhib. Med. Chem.
  doi: 10.1080/14756366.2016.1243535
  contributor:
    fullname: Mocan
– volume: 2
  start-page: 569
  year: 2014
  ident: 10.1016/j.biopha.2017.09.035_bib0165
  article-title: Analgesic effects of naringenin in rats with spinal nerve ligation-induced neuropathic pain
  publication-title: Biomed. Rep.
  doi: 10.3892/br.2014.267
  contributor:
    fullname: Hu
– volume: 13
  start-page: 1029
  year: 2014
  ident: 10.1016/j.biopha.2017.09.035_bib0055
  article-title: Combined anti-ages and antioxidant activities of different solvent extracts of Solanum elaeagnifolium cav (solanacea) fruits during ripeningand related to their phytochemical compositions
  publication-title: Excli J.
  contributor:
    fullname: Houda
– volume: 193
  start-page: 265
  year: 1951
  ident: 10.1016/j.biopha.2017.09.035_bib0085
  article-title: Protein measurement with the Folin phenol reagent
  publication-title: J. Biol Chem.
  doi: 10.1016/S0021-9258(19)52451-6
  contributor:
    fullname: Lowry
– volume: 43
  start-page: 329
  year: 2013
  ident: 10.1016/j.biopha.2017.09.035_bib0230
  article-title: The genetic architecture of liver enzyme levels: GGT, ALT and AST
  publication-title: Behav. Genet.
  doi: 10.1007/s10519-013-9593-y
  contributor:
    fullname: Van Beek
– volume: 16
  start-page: 26087
  year: 2015
  ident: 10.1016/j.biopha.2017.09.035_bib0260
  article-title: The role of oxidative stress and antioxidants in liver diseases
  publication-title: Inter. J. Mol. Sci.
  doi: 10.3390/ijms161125942
  contributor:
    fullname: Li
– volume: 67
  start-page: 637
  year: 2015
  ident: 10.1016/j.biopha.2017.09.035_bib0020
  article-title: Lycium Europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells
  publication-title: Nutr. Cancer
  doi: 10.1080/01635581.2015.1017054
  contributor:
    fullname: Ghali
– volume: 96
  start-page: 529
  year: 2005
  ident: 10.1016/j.biopha.2017.09.035_bib0270
  article-title: Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2004.09.054
  contributor:
    fullname: Ha
SSID ssj0005638
Score 2.3512301
Snippet [Display omitted] In this study, the antioxidant, antinociceptive, hepatoprotective, nephroprotective properties and the bioactive composition of Lycium...
In this study, the antioxidant, antinociceptive, hepatoprotective, nephroprotective properties and the bioactive composition of Lycium europaeum were...
SourceID crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 1441
SubjectTerms Analgesics - pharmacology
Analgesis
Animals
Antioxidant
Antioxidants - pharmacology
Bioactive compounds
Carbon Tetrachloride
CCl4
Flavonoids - analysis
Kidney - drug effects
Kidney - pathology
Kidneys
Liver
Liver - drug effects
Liver - pathology
Lycium - chemistry
Lycium europaeum
Male
Malondialdehyde - metabolism
Methanol
Mice
Phenols - analysis
Phytochemicals - pharmacology
Plant Extracts - pharmacology
Protective Agents - pharmacology
Quercetin - pharmacology
Rats, Wistar
Tannins - analysis
Toxicity Tests, Acute
Title Phytochemical characterization and bioactivity of Lycium europaeum: A focus on antioxidant, antinociceptive, hepatoprotective and nephroprotective effects
URI https://dx.doi.org/10.1016/j.biopha.2017.09.035
https://www.ncbi.nlm.nih.gov/pubmed/28946192
Volume 95
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