A circulating subset of iNKT cells mediates antitumor and antiviral immunity

• Published in: Science immunology Vol. 7; no. 76; p. eabj8760
• Main Authors: Cui, Guangwei, Shimba, Akihiro, Jin, Jianshi, Ogawa, Taisaku, Muramoto, Yukiko, Miyachi, Hitoshi, Abe, Shinya, Asahi, Takuma, Tani-Ichi, Shizue, Dijkstra, Johannes M, Iwamoto, Yayoi, Kryukov, Kirill, Zhu, Yuanbo, Takami, Daichi, Hara, Takahiro, Kitano, Satsuki, Xu, Yan, Morita, Hajime, Zhang, Moyu, Zreka, Lynn, Miyata, Keishi, Kanaya, Takashi, Okumura, Shinya, Ito, Takashi, Hatano, Etsuro, Takahashi, Yoshimasa, Watarai, Hiroshi, Oike, Yuichi, Imanishi, Tadashi, Ohno, Hiroshi, Ohteki, Toshiaki, Minato, Nagahiro, Kubo, Masato, Holländer, Georg A, Ueno, Hideki, Noda, Takeshi, Shiroguchi, Katsuyuki, Ikuta, Koichi
• Format: Journal Article
• Language: English
• Published: United States 01.10.2022
• Subjects: Animals; Granzymes; Humans; Interleukin-15; Lipids; Mice; Natural Killer T-Cells - metabolism; Natural Killer T-Cells - pathology; Receptors, Chemokine - metabolism; Receptors, Natural Killer Cell

Invariant natural killer T (iNKT) cells are a group of innate-like T lymphocytes that recognize lipid antigens. They are supposed to be tissue resident and important for systemic and local immune regulation. To investigate the heterogeneity of iNKT cells, we recharacterized iNKT cells in the thymus...