Duration of antibiotic treatment in disseminated Lyme borreliosis : a double-blind, randomized, placebo-controlled, multicenter clinical study

• Published in: European journal of clinical microbiology & infectious diseases Vol. 26; no. 8; pp. 571 - 581
• Main Authors: OKSI, J, NIKOSKELAINEN, J, VALTONEN, V, VILJANEN, M, HIEKKANEN, H, LAUHIO, A, PELTOMAA, M, PITKÄRANTA, A, NYMAN, D, GRANLUND, H, CARLSSON, S.-A, SEPPÄLÄ, I
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.08.2007; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin - administration & dosage; Anti-Bacterial Agents - administration & dosage; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial diseases; Biological and medical sciences; Borrelia; Borrelia burgdorferi; Borrelia burgdorferi - drug effects; Borrelia infections; Ceftriaxone - therapeutic use; Diseases of the osteoarticular system; Double-Blind Method; Drug Administration Schedule; Drug therapy; Drug Therapy, Combination; Erythema Chronicum Migrans - drug therapy; Female; Human bacterial diseases; Humans; Infectious diseases; Lyme Neuroborreliosis - drug therapy; Male; Medical sciences; Middle Aged; Miscellaneous. Osteoarticular involvement in other diseases; Pharmacology. Drug treatments; Placebos; Treatment Outcome; Tropical bacterial diseases; Lyme disease; Prognosis; Intravenous administration; Spirochaetaceae; Multicenter study; Diseases of the osteoarticular system; Central nervous system; Arthritis; Ceftriaxone; Penicillin derivatives; Spirochaetosis; Bacteria; Diagnosis; Disseminated; Human; Borrelia burgdorferi; Spirochaetales; β-Lactams; Borrelia infection; Oral administration; Infection; Symptomatology; Cephalosporin derivatives; Antibiotic; Chemotherapy; Chronic; Treatment; Amoxicillin; Bacteriosis; Antibacterial agent

Despite rather strict recommendations for antibiotic treatment of disseminated Lyme borreliosis (LB), evidence-based studies on the duration of antibiotic treatment are scarce. The aim of this multicenter study was to determine whether initial treatment with intravenous ceftriaxone (CRO) for 3 weeks...