Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

• Published in: The Journal of experimental medicine Vol. 201; no. 6; pp. 937 - 947
• Main Authors: Wark, Peter A.B., Johnston, Sebastian L., Bucchieri, Fabio, Powell, Robert, Puddicombe, Sarah, Laza-Stanca, Vasile, Holgate, Stephen T., Davies, Donna E.
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 21.03.2005
• Subjects: Adult; Antiviral Agents - immunology; Antiviral Agents - therapeutic use; Apoptosis - immunology; Asthma - drug therapy; Asthma - immunology; Asthma - virology; Bronchi - cytology; Bronchi - immunology; Bronchi - virology; Caspase 3; Caspase 7; Caspases - immunology; Cells, Cultured; Epithelial Cells - immunology; Epithelial Cells - virology; Female; Gene Expression Regulation - immunology; Humans; Immunity, Innate; Interferon-beta - immunology; Interferon-beta - therapeutic use; Male; Middle Aged; Picornaviridae Infections - complications; Picornaviridae Infections - drug therapy; Picornaviridae Infections - immunology; Rhinovirus; Rhinovirus - immunology; RNA, Viral - biosynthesis; Virus Replication - immunology

Rhinoviruses are the major trigger of acute asthma exacerbations and asthmatic subjects are more susceptible to these infections. To investigate the underlying mechanisms of this increased susceptibility, we examined virus replication and innate responses to rhinovirus (RV)-16 infection of primary b...