Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus - Wark, Peter A.B.; Johnston, Sebastian L.; Bucchieri, Fabio; Powell, Robert; Puddicombe, Sarah; Laza-Stanca, Vasile; Holgate, Stephen T.; Davies, Donna E. (The Journal of experimental medicine, 2005)
Keywords: Adult; Antiviral Agents - immunology; Antiviral Agents - therapeutic use; Apoptosis - immunology; Asthma - drug therapy; Asthma - immunology; Asthma - virology; Bronchi - cytology; Bronchi - immunology; Bronchi - virology; Caspase 3; Caspase 7; Caspases - immunology; Cells, Cultured; Epithelial Cells - immunology; Epithelial Cells - virology; Female; Gene Expression Regulation - immunology; Humans; Immunity, Innate; Interferon-beta - immunology; Interferon-beta - therapeutic use; Male; Middle Aged; Picornaviridae Infections - complications; Picornaviridae Infections - drug therapy; Picornaviridae Infections - immunology; Rhinovirus; Rhinovirus - immunology; RNA, Viral - biosynthesis; Virus Replication - immunology